EC Number |
Disease |
PubMed ID |
Title of Publication |
Category |
Confidence Level |
---|
3.4.22.52 | Alzheimer Disease |
7847693 |
Calcium-activated neutral proteinase (calpain) system in aging and Alzheimer's disease. |
causal interaction diagnostic usage ongoing research unassigned |
3 3 1 0 |
3.4.22.52 | Alzheimer Disease |
8464868 |
Widespread activation of calcium-activated neutral proteinase (calpain) in the brain in Alzheimer disease: a potential molecular basis for neuronal degeneration. |
causal interaction diagnostic usage ongoing research therapeutic application |
3 4 2 1 |
3.4.22.52 | Alzheimer Disease |
11516996 |
The calpain family and human disease. |
causal interaction diagnostic usage unassigned |
4 1 0 |
3.4.22.52 | Alzheimer Disease |
12070670 |
Calpain activation in neurodegenerative diseases: confocal immunofluorescence study with antibodies specifically recognizing the active form of calpain 2. |
causal interaction diagnostic usage ongoing research therapeutic application |
3 2 2 2 |
3.4.22.52 | Alzheimer Disease |
17157313 |
The crystal structures of human calpains 1 and 9 imply diverse mechanisms of action and auto-inhibition. |
causal interaction ongoing research unassigned |
1 3 0 |
3.4.22.52 | Alzheimer Disease |
18396356 |
Design and synthesis of calpain inhibitory 6-pyridone 2-carboxamide derivatives. |
causal interaction therapeutic application unassigned |
2 4 0 |
3.4.22.52 | Alzheimer Disease |
25641096 |
Truncation and activation of GSK-3? by calpain I: a molecular mechanism links to tau hyperphosphorylation in Alzheimer's disease. |
causal interaction unassigned |
3 0 |
3.4.22.52 | Alzheimer Disease |
25918155 |
Truncation and Activation of Dual Specificity Tyrosine Phosphorylation-regulated Kinase 1A by Calpain I: A MOLECULAR MECHANISM LINKED TO TAU PATHOLOGY IN ALZHEIMER DISEASE. |
causal interaction unassigned |
1 0 |
3.4.22.52 | Alzheimer Disease |
32328086 |
Deletion of the Capn1 Gene Results in Alterations in Signaling Pathways Related to Alzheimer's Disease, Protein Quality Control and Synaptic Plasticity in Mouse Brain. |
causal interaction diagnostic usage unassigned |
4 1 0 |
3.4.22.52 | Amyotrophic Lateral Sclerosis |
31982778 |
Mutation analysis of CAPN1 in Chinese populations with spastic paraplegia and related neurodegenerative diseases. |
causal interaction unassigned |
4 0 |