EC Number   |
Disease  |
PubMed ID |
Title of Publication |
Category |
Confidence Level |
|---|
   3.4.22.52 | Alzheimer Disease |
9296555 |
Active site-directed antibodies identify calpain II as an early-appearing and pervasive component of neurofibrillary pathology in Alzheimer's disease. |
causal interaction
ongoing research
unassigned |
3
1
0 |
| 3.4.22.52 | Alzheimer Disease |
11516996 |
The calpain family and human disease. |
causal interaction
diagnostic usage
unassigned |
4
1
0 |
| 3.4.22.52 | Alzheimer Disease |
12070670 |
Calpain activation in neurodegenerative diseases: confocal immunofluorescence study with antibodies specifically recognizing the active form of calpain 2. |
causal interaction
diagnostic usage
ongoing research
therapeutic application |
3
2
2
2 |
| 3.4.22.52 | Alzheimer Disease |
16150694 |
Truncation and activation of calcineurin A by calpain I in Alzheimer disease brain. |
unassigned |
0 |
| 3.4.22.52 | Alzheimer Disease |
17157313 |
The crystal structures of human calpains 1 and 9 imply diverse mechanisms of action and auto-inhibition. |
causal interaction
ongoing research
unassigned |
1
3
0 |
| 3.4.22.52 | Alzheimer Disease |
18396356 |
Design and synthesis of calpain inhibitory 6-pyridone 2-carboxamide derivatives. |
causal interaction
therapeutic application
unassigned |
2
4
0 |
| 3.4.22.52 | Alzheimer Disease |
19041242 |
Design and synthesis of 4-aryl-4-oxobutanoic acid amides as calpain inhibitors. |
causal interaction
therapeutic application
unassigned |
2
4
0 |
| 3.4.22.52 | Alzheimer Disease |
23834438 |
Design, synthesis, and optimization of novel epoxide incorporating peptidomimetics as selective calpain inhibitors. |
unassigned |
0 |
| 3.4.22.52 | Alzheimer Disease |
25476568 |
Accumulation of ?-synuclein in dementia with Lewy bodies is associated with decline in the ?-synuclein-degrading enzymes kallikrein-6 and calpain-1. |
diagnostic usage
ongoing research
unassigned |
3
1
0 |
| 3.4.22.52 | Alzheimer Disease |
25641096 |
Truncation and activation of GSK-3? by calpain I: a molecular mechanism links to tau hyperphosphorylation in Alzheimer's disease. |
causal interaction
unassigned |
3
0 |
