EC Number   |
Disease |
PubMed ID |
Title of Publication |
Category |
Confidence Level |
|---|
   3.4.22.52 | Alzheimer Disease |
25918155 |
Truncation and Activation of Dual Specificity Tyrosine Phosphorylation-regulated Kinase 1A by Calpain I: A MOLECULAR MECHANISM LINKED TO TAU PATHOLOGY IN ALZHEIMER DISEASE. |
causal interaction
unassigned |
1
0 |
| 3.4.22.52 | Alzheimer Disease |
26484927 |
Novel Selective Calpain 1 Inhibitors as Potential Therapeutics in Alzheimer's Disease. |
causal interaction
therapeutic application
unassigned |
4
4
0 |
| 3.4.22.52 | Alzheimer Disease |
28267204 |
C-terminal truncation of GSK-3? enhances its dephosphorylation by PP2A. |
unassigned |
0 |
| 3.4.22.52 | Alzheimer Disease |
29614685 |
Calpain I Activation Causes GLUT3 Proteolysis and Downregulation of O-GlcNAcylation in Alzheimer's Disease Brain. |
causal interaction
unassigned |
4
0 |
| 3.4.22.52 | Alzheimer Disease |
30052328 |
Pharmacokinetics, Safety, Tolerability, and Pharmacodynamics of Alicapistat, a Selective Inhibitor of Human Calpains 1 and 2 for the Treatment of Alzheimer Disease: An Overview of Phase 1 Studies. |
causal interaction
therapeutic application
unassigned |
3
4
0 |
| 3.4.22.52 | Alzheimer Disease |
32039889 |
An unexpected co-crystal structure of the calpain PEF(S) domain with Hfq reveals a potential chaperone function of Hfq. |
causal interaction
therapeutic application
unassigned |
3
4
0 |
| 3.4.22.52 | Alzheimer Disease |
32328086 |
Deletion of the Capn1 Gene Results in Alterations in Signaling Pathways Related to Alzheimer's Disease, Protein Quality Control and Synaptic Plasticity in Mouse Brain. |
causal interaction
diagnostic usage
unassigned |
4
1
0 |
| 3.4.22.52 | Alzheimer Disease |
33615187 |
Extending the Calpain-Cathepsin Hypothesis to the Neurovasculature: Protection of Brain Endothelial Cells and Mice from Neurotrauma. |
causal interaction
therapeutic application
unassigned |
3
1
0 |
| 3.4.22.52 | Amyotrophic Lateral Sclerosis |
25151305 |
Role of calpain-1 in the early phase of experimental ALS. |
unassigned |
0 |
| 3.4.22.52 | Amyotrophic Lateral Sclerosis |
31982778 |
Mutation analysis of CAPN1 in Chinese populations with spastic paraplegia and related neurodegenerative diseases. |
causal interaction
unassigned |
4
0 |
