EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
3.4.22.52 | casein + H2O |
- |
Bos taurus |
? |
- |
? |
3.4.22.52 | Frizzled-7 + H2O |
- |
Bos taurus |
? |
- |
? |
3.4.22.52 | Frizzled-7 + H2O |
calpain-1 is a regulator of Frizzled-7 turnover at the plasma membrane |
Bos taurus |
? |
- |
? |
3.4.22.52 | more |
primary role of calpain 1 and calpain 3 in meat tenderization |
Bos taurus |
? |
- |
? |
3.4.22.52 | more |
because the calcium concentration in postmortem muscle is high enough to activate mu-calpain, but not m-calpain, it seems reasonable to conclude that mu-calpain is responsible for postmortem degradation of calpastatin. Degradation of calpastatin by mu-calpain reduces calpain-inhibitory activity and is probably an important event in regulation of postmortem proteolysis, and, thus, meat tenderness |
Bos taurus |
? |
- |
? |
3.4.22.52 | more |
calpastatin could play an important role in preventing uncontrolled activity of l-calpain which otherwise may facilitate pulmonary hypertension, smooth muscle proliferation and apoptosis |
Bos taurus |
? |
- |
? |
3.4.22.52 | myofibril + H2O |
- |
Bos taurus |
? |
- |
? |
3.4.22.52 | RhoA + H2O |
- |
Bos taurus |
? |
- |
? |
3.4.22.52 | RhoA + H2O |
calpain cleaves RhoA and generates a form that inhibits integrin-induced stress fiber assembly and cell spreading |
Bos taurus |
? |
- |
? |
3.4.22.52 | titin + H2O |
pH 7.5, absence or presence of 12 microM calcium |
Bos taurus |
? |
- |
? |