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EC Number
Substrates
Commentary Substrates
Organism
Products
Commentary (Products)
Reversibility
3.4.22.B50
ubiquitin-7-amido-4-methylcoumarin + H2O
-
Alphacoronavirus
?
-
?
3.4.22.B50
ubiquitin-7-amido-4-methylcoumarin + H2O
-
Alphacoronavirus SARS-CoV
?
-
?
3.4.22.B50
ubiquitin-7-amido-4-trifluoro-methyl-coumarin + H2O
-
porcine epidemic diarrhea virus
ubiquitin + 7-amino-4-trifluoro-methyl-coumarin
-
?
3.4.22.B50
ubiquitin-7-amido-4-trifluoromethylcoumarin + H2O
the enzyme catalyzes proteolytic processing of the viral polyprotein and also shows significant in vitro deubiquitinating and de-ISGylating activities. The enzyme binds ubiquitin, the ubiquitin core makes mostly hydrophilic interactions with the enzyme, while the Leu-Arg-Gly-Gly C-terminus of ubiquitin is located in the catalytic cleft of the enzyme. The ubiquitin core binds to the palm, thumb and fingers domains of the enzyme, while its final four C-terminal residues bind into a narrow channel by a network of hydrogen bonds and reach towards the active site
Severe acute respiratory syndrome-related coronavirus
ubiquitin + 7-amino-4-trifluoromethylcoumarin
-
?
3.4.22.B50
ubiquitin-aminomethylcoumarin + H2O
-
equine arteritis virus
?
-
?
3.4.22.B50
ubiquitinated branched peptides + H2O
-
Human coronavirus NL63
?
-
?
3.4.22.B50
ubiquitinated RIG-I + H2O
-
porcine epidemic diarrhea virus
deubiquitinated RIG-I + ubiquitin
-
?
3.4.22.B50
ubiquitinated STING + H2O
-
porcine epidemic diarrhea virus
deubiquitinated STING + ubiquitin
-
?
3.4.22.B50
VAKQGAGFKRTY + H2O
-
Human coronavirus NL63
VAKQGA + GFKRTY
-
?
3.4.22.B50
viral replicase polyprotein + H2O
PLP2 is responsible for processing both cleavage sites 2 and 3 to release nsp2 and nsp3. The cleavage sites are identified as FTKLAG-/-GKISFS for CS2 and VAKQGA-/-GFKRTY for CS3.
Human coronavirus NL63
?
-
?
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