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EC Number
Substrates
Commentary Substrates
Organism
Products
Commentary (Products)
Reversibility
3.4.22.B50
ISLKGGKIVSTC
12 mer oligopeptide containing Gly2740-Lys2741, 29% cleavage
Alphacoronavirus
?
-
?
3.4.22.B50
ISLKGGKIVSTC
12 mer oligopeptide containing Gly2740-Lys2741, 29% cleavage
Alphacoronavirus SARS-CoV
?
-
?
3.4.22.B50
MHV substrate
-
Alphacoronavirus
?
-
?
3.4.22.B50
more
Cys1715 is a catalytic residue of PLP2
Murine coronavirus
?
-
?
3.4.22.B50
more
no in vitro cleavage of the ORF 1a polyprotein in cis or in trans can be detected with PLP-2 expressed either as a polypeptide, including flanking viral sequences, or as an MBP fusion protein
Murine coronavirus
?
-
?
3.4.22.B50
more
the enzyme is one of three distinct viral proteases (PLP1, PLP2 and 3CLpro) involved in processing of the replicase polyprotein
Murine coronavirus
?
-
?
3.4.22.B50
more
SARS-CoV PLP2 does not cleave HCoV.229E and IBV substrates
Alphacoronavirus
?
-
?
3.4.22.B50
more
proteolytic processing of the human coronavirus 229E. PL2pro is able to cleave the nsp1-nsp2 cleavage site. PL2pro plays a universal and essential proteolytic role that appears to be assisted by the PL1pro paralog at specific sites
Human coronavirus 229E
?
-
?
3.4.22.B50
more
the core domain of PLP2 has in vivo deubiquitinase and DeISGylation activity
Human coronavirus NL63
?
-
?
3.4.22.B50
more
the enzyme cannot cleave Z-KAGG-7-amido-4-methylcoumarin
infectious bronchitis virus
?
-
?
Results
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