EC Number |
Recommended Name |
Source Tissue |
Reference |
---|
1.13.11.52 | indoleamine 2,3-dioxygenase |
cerebrospinal fluid |
from humans suffering from inflammatory neurological disorders exhibit increased IDO activity |
666895 |
1.14.17.1 | dopamine beta-monooxygenase |
cerebrospinal fluid |
the DBH activity:DBH protein ratio is the same in human serum and cerebrospinal fluid and does not change in patients with Parkinson disease, whose cerebrospinal fluid has very low DBH activity and protein levels compared with cerebrospinal fluid from healthy individuals |
703268 |
1.16.3.1 | ferroxidase |
cerebrospinal fluid |
in fluid from patients with Parkinson's disease, Alzheimer's disease, Huntington's disease, a significantly decreased ferroxidase activity is found agreeing with findings of iron deposition in these entities, while free copper is found to be increased in cerebrospinal fluid and appears to be a good biomarker of Parkinson's disease. The sum of nitrites and nitrates as end products of nitric oxide are increased in the degenerative diseases Parkinson's disease, Alzheimer's disease, Huntington's disease and lateral amyotrophic sclerosis and fluorescent lipoperoxidation products in three of them, excepting lateral amyotrophic sclerosis |
689179 |
1.4.3.3 | D-amino-acid oxidase |
cerebrospinal fluid |
- |
723921 |
2.3.1.43 | phosphatidylcholine-sterol O-acyltransferase |
cerebrospinal fluid |
- |
736889 |
2.3.1.6 | choline O-acetyltransferase |
cerebrospinal fluid |
- |
737113, 756803 |
2.3.2.5 | glutaminyl-peptide cyclotransferase |
cerebrospinal fluid |
- |
758620 |
2.3.2.5 | glutaminyl-peptide cyclotransferase |
cerebrospinal fluid |
slightly lower glutaminyl cyclase activity in cerebrospinal fluid of multiple sclerosis patients compared to controls. The presence of glutaminyl cyclase in cerebrospinal fluid can stabilize peptides from degradation by aminopeptidases |
686164 |
2.4.2.1 | purine-nucleoside phosphorylase |
cerebrospinal fluid |
- |
662951 |
2.4.2.26 | protein xylosyltransferase |
cerebrospinal fluid |
- |
637616 |
3.1.1.4 | phospholipase A2 |
cerebrospinal fluid |
- |
708167 |
3.1.1.47 | 1-alkyl-2-acetylglycerophosphocholine esterase |
cerebrospinal fluid |
isozyme II, of children with meningitis |
649522 |
3.1.1.7 | acetylcholinesterase |
cerebrospinal fluid |
from patients with cerebral tumor, cerebral haemorrhage, bacterial meningitis and encephalitis, hydrocephalus |
650863 |
3.1.3.2 | acid phosphatase |
cerebrospinal fluid |
- |
664939 |
3.1.3.25 | inositol-phosphate phosphatase |
cerebrospinal fluid |
- |
114241 |
3.1.4.12 | sphingomyelin phosphodiesterase |
cerebrospinal fluid |
cerebrospinal fluid contains a detectable level of secretory enzyme, which is unrelated to serum enzyme activity, no influence of sex or age on enzyme activity in cerebrospinal fluid |
730731 |
3.1.4.39 | alkylglycerophosphoethanolamine phosphodiesterase |
cerebrospinal fluid |
- |
664939 |
3.1.4.39 | alkylglycerophosphoethanolamine phosphodiesterase |
cerebrospinal fluid |
high phosphodiesterase Ialpha/autotoxin levels |
696397 |
3.2.1.31 | beta-glucuronidase |
cerebrospinal fluid |
- |
26870 |
3.2.2.19 | [protein ADP-ribosylarginine] hydrolase |
cerebrospinal fluid |
- |
137046 |
3.4.13.20 | beta-Ala-His dipeptidase |
cerebrospinal fluid |
CN1 activity is considerably higher in serum than in cerebrospinal fluid |
707087 |
3.4.14.4 | dipeptidyl-peptidase III |
cerebrospinal fluid |
- |
683203 |
3.4.14.5 | dipeptidyl-peptidase IV |
cerebrospinal fluid |
- |
703784 |
3.4.15.1 | peptidyl-dipeptidase A |
cerebrospinal fluid |
- |
701190, 81244 |
3.4.17.2 | carboxypeptidase B |
cerebrospinal fluid |
majority of the enzyme exists in the prepro-form |
653363 |
3.4.17.21 | Glutamate carboxypeptidase II |
cerebrospinal fluid |
ventricular, lumbar, and subarachnoid |
707124 |
3.4.17.23 | angiotensin-converting enzyme 2 |
cerebrospinal fluid |
- |
754629 |
3.4.19.12 | ubiquitinyl hydrolase 1 |
cerebrospinal fluid |
UCH-L1 is significantly elevated in cerebrospinal fluid following controlled cortical impact and middle cerebral artery occlusion, as a model of ischemic stroke, in rats, overview |
708390 |
3.4.19.12 | ubiquitinyl hydrolase 1 |
cerebrospinal fluid |
UCH-L1 levels are specifically increased in cerebrospinal fluid in case of traumatic brain damage, quantitative determination in different samples, overview |
708233 |
3.4.19.12 | ubiquitinyl hydrolase 1 |
cerebrospinal fluid |
UCHL1 content determination in benign and malign samples, overview |
709625 |
3.4.21.117 | stratum corneum chymotryptic enzyme |
cerebrospinal fluid |
- |
664621 |
3.4.21.117 | stratum corneum chymotryptic enzyme |
cerebrospinal fluid |
decrease in level of kallikrein 7 in patients with Alzheimer's disease and patients with frontotemporal dementia |
664614 |
3.4.21.119 | kallikrein 13 |
cerebrospinal fluid |
traces |
647372 |
3.4.21.5 | thrombin |
cerebrospinal fluid |
high levels of thrombin are detected in cerebrospinal fluid obtained from Alzheimer's disease but not control patients |
707050 |
3.4.21.79 | granzyme B |
cerebrospinal fluid |
- |
697673 |
3.4.21.79 | granzyme B |
cerebrospinal fluid |
expressed in the cerebrospinal fluid of multiple sclerosis and Rasmussen encephalitis patients |
709759 |
3.4.21.B10 | neurosin |
cerebrospinal fluid |
in synucleinopathies, including Parkinson disease, the levels of KLK6 inversely correlate with alpha-synuclein in cerebrospinal fluid |
754959 |
3.4.21.B10 | neurosin |
cerebrospinal fluid |
present as the proenzyme |
665086 |
3.4.22.62 | caspase-9 |
cerebrospinal fluid |
caspase-9 is released into the cerebrospinal fluid after severe traumatic brain injury |
710088 |
3.4.23.46 | memapsin 2 |
cerebrospinal fluid |
- |
697366, 754736 |
3.4.23.46 | memapsin 2 |
cerebrospinal fluid |
development of assay for cerebrospinal fluid beta-secretase-1 activity with sensitivity down to 1 pM of recombinant enzyme. Endogenous secretase-1 enzyme appears to exist as a C-terminally truncated protein. A small cohort of human subjects displays age-dependent increase in cerebrospinal fluid beta-secretase-1 activity. In Alzheimer's disease subjects, a significant decline in age-adjusted cerebrospinal fluid beta-secretase-1 activity is observed |
697366 |
3.4.23.5 | cathepsin D |
cerebrospinal fluid |
- |
711855 |
3.4.24.11 | neprilysin |
cerebrospinal fluid |
- |
81646 |
3.4.24.35 | gelatinase B |
cerebrospinal fluid |
- |
670899, 697747 |
3.4.24.71 | endothelin-converting enzyme 1 |
cerebrospinal fluid |
- |
734684, 755423 |
3.4.24.81 | ADAM10 endopeptidase |
cerebrospinal fluid |
- |
644077 |
3.5.1.3 | omega-amidase |
cerebrospinal fluid |
- |
288884, 288893 |
3.5.4.4 | adenosine deaminase |
cerebrospinal fluid |
- |
733674, 756910 |
3.5.4.4 | adenosine deaminase |
cerebrospinal fluid |
the enzyme activity is highest in tuberculous meningitis patients, followed by non-infectious meningitis patients and healthy persons, the latter showing the lowest activity |
668232 |
4.1.1.45 | aminocarboxymuconate-semialdehyde decarboxylase |
cerebrospinal fluid |
- |
749404 |
5.3.99.2 | Prostaglandin-D synthase |
cerebrospinal fluid |
- |
3115, 726907, 747600 |
5.3.99.2 | Prostaglandin-D synthase |
cerebrospinal fluid |
identification of several enzyme isoforms |
682618 |
5.3.99.2 | Prostaglandin-D synthase |
cerebrospinal fluid |
qualitative and quantitative fluctuations of prostaglandin D synthase isoforms from cerebrospinal fluid reflect both major and subtle brain pathophysiology |
661570 |
5.3.99.2 | Prostaglandin-D synthase |
cerebrospinal fluid |
richest source of the enzyme |
3111 |
5.3.99.2 | Prostaglandin-D synthase |
cerebrospinal fluid |
second major protein |
726906 |
6.3.1.2 | glutamine synthetase |
cerebrospinal fluid |
- |
37568 |