EC Number |
Recommended Name |
Source Tissue |
Reference |
---|
1.1.1.188 | prostaglandin-F synthase |
breast |
normal breast expresses very high levels of AKR1C3 relative to other tissues |
697271 |
1.1.1.22 | UDP-glucose 6-dehydrogenase |
breast |
- |
762065 |
1.1.1.27 | L-lactate dehydrogenase |
breast |
- |
740255 |
1.1.1.27 | L-lactate dehydrogenase |
breast |
normal and malignant human breast tissues |
740253 |
1.1.1.37 | malate dehydrogenase |
breast |
- |
760668 |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
breast |
- |
656371, 686263, 713021, 740542 |
1.1.1.8 | glycerol-3-phosphate dehydrogenase (NAD+) |
breast |
- |
762072 |
1.11.1.8 | iodide peroxidase |
breast |
the molecular weight of breast TPO is slightly lower than that of thyroid TPO due to decreased glycosylation. Enzymatic activity and isoelectric point of the isomforms are comparable |
765648 |
1.14.11.2 | procollagen-proline 4-dioxygenase |
breast |
- |
744594 |
1.14.13.8 | flavin-containing monooxygenase |
breast |
- |
673313 |
1.14.14.79 | docosahexaenoic acid omega-hydroxylase |
breast |
- |
728344 |
1.14.15.18 | calcidiol 1-monooxygenase |
breast |
- |
671357, 672857, 675686, 695621 |
1.14.15.18 | calcidiol 1-monooxygenase |
breast |
enzyme expression analysis in different samples of women with and without breast cancer, no correlation with breast cancer development |
675679 |
1.2.1.105 | 2-oxoglutarate dehydrogenase system |
breast |
- |
672280 |
1.2.1.36 | retinal dehydrogenase |
breast |
- |
655948 |
1.3.1.21 | 7-dehydrocholesterol reductase |
breast |
exocrine, high desmosterol synthesis |
656819 |
1.6.3.1 | NAD(P)H oxidase (H2O2-forming) |
breast |
- |
711688 |
2.1.1.63 | methylated-DNA-[protein]-cysteine S-methyltransferase |
breast |
AGT expression is increased in breast cancer compared to normal breast |
673219 |
2.2.1.1 | transketolase |
breast |
only 29% of non-neoplastic breast tissues are TKTL1 immunopositive, including 9% with high expression levels |
694502 |
2.3.1.135 | phosphatidylcholine-retinol O-acyltransferase |
breast |
- |
674069 |
2.3.1.24 | sphingosine N-acyltransferase |
breast |
- |
736471 |
2.3.1.5 | arylamine N-acetyltransferase |
breast |
healthy and neoplastic tissue |
676155 |
2.4.1.17 | glucuronosyltransferase |
breast |
- |
488786, 488790, 735649, 759116 |
2.4.1.17 | glucuronosyltransferase |
breast |
identification of isozyme UGT1A10 in non-malignant and malignant human breast tissues, UGT1A10 and UGT2B7 mRNAs are differentially expressed among healthy and malignant specimens, in African American women, UGT1A10 expression is significantly decreased in breast carcinomas in comparison to healthy, while among Caucasian women, overview |
695149 |
2.4.1.17 | glucuronosyltransferase |
breast |
low expression level |
759116 |
2.4.1.17 | glucuronosyltransferase |
breast |
UGT1A10 and UGT2B7 mRNAs are differentially expressed among healthy and malignant specimens, in African American women, UGT2B7 is significantly decreased in breast carcinomas in comparison to healthy, overview |
695149 |
2.4.2.4 | thymidine phosphorylase |
breast |
ductal carcinoma in situ and invasive elements |
638469 |
2.4.2.4 | thymidine phosphorylase |
breast |
tumor specimen |
638461, 638468 |
2.7.1.137 | phosphatidylinositol 3-kinase |
breast |
- |
640952 |
2.7.1.147 | ADP-specific glucose/glucosamine kinase |
breast |
- |
723169 |
2.7.1.154 | phosphatidylinositol-4-phosphate 3-kinase |
breast |
- |
640931, 640952 |
2.7.1.154 | phosphatidylinositol-4-phosphate 3-kinase |
breast |
low amount of isozyme PI3K-C2alpha in myoepithelial cells and lactiferous ducts, no isozyme PI3K-C2beta and isozyme p85 |
645046 |
2.7.1.154 | phosphatidylinositol-4-phosphate 3-kinase |
breast |
non-neoplastic breast tissues |
739216 |
2.7.1.154 | phosphatidylinositol-4-phosphate 3-kinase |
breast |
PI3KC2gamma |
672858 |
2.7.1.3 | ketohexokinase |
breast |
relatively low expression of ketohexokinase.The expression profile for ketohexokinase in human is derived from from Unigene by adding the number of EST clones obtained from normal tissues |
678985 |
2.7.1.32 | choline kinase |
breast |
- |
673201 |
2.7.1.40 | pyruvate kinase |
breast |
activity in tumor tissue is higher than in normal tissue |
660823 |
2.7.1.91 | sphingosine kinase |
breast |
- |
671356, 702084 |
2.7.10.1 | receptor protein-tyrosine kinase |
breast |
- |
661457 |
2.7.10.1 | receptor protein-tyrosine kinase |
breast |
high expression level of ErbB1 receptor |
660873 |
2.7.10.2 | non-specific protein-tyrosine kinase |
breast |
epithelium, Syk occurs in MDA-MB-468 cells, but not in BT-549 cells |
661457 |
2.7.10.2 | non-specific protein-tyrosine kinase |
breast |
Frk, Brk, Src, Fyn, Yes |
660885 |
2.7.11.1 | non-specific serine/threonine protein kinase |
breast |
- |
708371 |
2.7.11.10 | IkappaB kinase |
breast |
- |
676886 |
2.7.11.13 | protein kinase C |
breast |
- |
695064 |
2.7.11.18 | myosin-light-chain kinase |
breast |
- |
640647 |
2.7.11.19 | phosphorylase kinase |
breast |
- |
676038 |
2.7.11.21 | polo kinase |
breast |
- |
703598 |
2.7.11.24 | mitogen-activated protein kinase |
breast |
- |
665638 |
2.7.11.25 | mitogen-activated protein kinase kinase kinase |
breast |
- |
665600 |
2.7.8.2 | diacylglycerol cholinephosphotransferase |
breast |
- |
705452 |
2.8.2.2 | alcohol sulfotransferase |
breast |
- |
675680 |
2.8.2.2 | alcohol sulfotransferase |
breast |
cancer tissue |
645741 |
2.8.2.29 | [heparan sulfate]-glucosamine 3-sulfotransferase 2 |
breast |
- |
662996 |
2.8.2.4 | estrone sulfotransferase |
breast |
- |
671361, 674994, 691194, 691624 |
3.1.3.11 | fructose-bisphosphatase |
breast |
- |
690771 |
3.1.3.11 | fructose-bisphosphatase |
breast |
FBP1 is commonly upregulated in tumor tissues compared with non-tumor tissues regardless of histological type. Enzyme expression profiles of breast cancer cells reveals that cells exhibiting high expression of FBP1 have a lower activity of Wnt/beta-catenin pathway |
750008 |
3.1.3.46 | fructose-2,6-bisphosphate 2-phosphatase |
breast |
- |
664248 |
3.1.3.67 | phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase |
breast |
- |
694494 |
3.1.6.12 | N-acetylgalactosamine-4-sulfatase |
breast |
- |
707573 |
3.1.6.2 | steryl-sulfatase |
breast |
- |
714906 |
3.1.6.2 | steryl-sulfatase |
breast |
fibroblasts from normal and malignant breast tissue, study of the regulation of STS mRNA expression |
656640 |
3.1.6.2 | steryl-sulfatase |
breast |
moderate level of enzyme immunoreactivity |
681644 |
3.2.1.35 | hyaluronoglucosaminidase |
breast |
HPH-20 |
664596 |
3.2.1.51 | alpha-L-fucosidase |
breast |
- |
739213 |
3.3.2.11 | cholesterol-5,6-oxide hydrolase |
breast |
- |
752861 |
3.4.13.9 | Xaa-Pro dipeptidase |
breast |
- |
707010 |
3.4.14.5 | dipeptidyl-peptidase IV |
breast |
- |
695514 |
3.4.17.21 | Glutamate carboxypeptidase II |
breast |
quantitative expression analysis |
670740 |
3.4.17.3 | lysine carboxypeptidase |
breast |
the amount of CPN is increased in tumor tissues compared to that seen in normal breast tissue |
731670 |
3.4.19.12 | ubiquitinyl hydrolase 1 |
breast |
- |
698156 |
3.4.19.12 | ubiquitinyl hydrolase 1 |
breast |
mRNA expression levels in normal breast tissue are not significantly different between premenopausal and postmenopausal women for both UCH-L1 and UCH-L3 |
679040 |
3.4.19.6 | pyroglutamyl-peptidase II |
breast |
- |
753360 |
3.4.19.9 | folate gamma-glutamyl hydrolase |
breast |
- |
683368 |
3.4.21.109 | matriptase |
breast |
- |
683492 |
3.4.21.109 | matriptase |
breast |
co-expression of matriptase and its substrate serine protease prostasin |
717902 |
3.4.21.117 | stratum corneum chymotryptic enzyme |
breast |
- |
647332, 707996 |
3.4.21.119 | kallikrein 13 |
breast |
- |
647372, 647373 |
3.4.21.122 | transmembrane protease serine 2 |
breast |
low expression level |
753135 |
3.4.21.34 | plasma kallikrein |
breast |
synthesis of prekallikrein |
683208 |
3.4.21.35 | tissue kallikrein |
breast |
KLK4 |
678522 |
3.4.21.35 | tissue kallikrein |
breast |
lower content |
647332 |
3.4.21.42 | complement subcomponent C1s |
breast |
- |
753047 |
3.4.21.77 | semenogelase |
breast |
female |
647332 |
3.4.21.77 | semenogelase |
breast |
surgical specimens from female patients with breast cancer |
718164 |
3.4.21.B10 | neurosin |
breast |
- |
731397 |
3.4.21.B10 | neurosin |
breast |
high expression level |
647332 |
3.4.21.B12 | prostase |
breast |
- |
647334 |
3.4.21.B28 | fibroblast activation protein alpha subunit |
breast |
cancer stroma cells |
650762 |
3.4.21.B39 | stratum corneum tryptic enzyme |
breast |
- |
680680 |
3.4.21.B39 | stratum corneum tryptic enzyme |
breast |
expression levels of KLK5 and KLK7 in benign breast tissues and metastases, and the relationship between KLK5 and KLK7 expression and and clinicopathological factors. mRNA levels of KLK5 and KLK7 in normal breast tissues, benign breast tissues, primary tumors, and lymph node metastases, overview. mRNA levels of KLK5 and KLK7 are both downregulated in breast cancers relative to normal and benign tissues, and downregulated in metastases compared to primary cancers |
707996 |
3.4.21.B39 | stratum corneum tryptic enzyme |
breast |
high expression |
670978 |
3.4.21.B39 | stratum corneum tryptic enzyme |
breast |
high expression level |
647332 |
3.4.21.B41 | kallikrein 10 |
breast |
- |
678524 |
3.4.21.B41 | kallikrein 10 |
breast |
expression in normal cells, but no expression in breast cancer cells |
670979 |
3.4.21.B41 | kallikrein 10 |
breast |
KLK10 is not methylated in normal breast tissues and fibroadenomas while it is in 5 of 10 breast tumors and in 1 of 10 matching normal tissues |
690443 |
3.4.21.B43 | kallikrein 12 |
breast |
gene expression of the enzyme is down-regulated in breast cancer |
647367 |
3.4.21.B43 | kallikrein 12 |
breast |
low content |
647367 |
3.4.21.B6 | prostasin |
breast |
co-expression of matriptase and its substrate serine protease prostasin |
717902 |
3.4.22.15 | cathepsin L |
breast |
- |
678521 |