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Results 1 - 10 of 15 > >>
EC Number General Information Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.16evolution cathepsin H is a member of the papain superfamily of lysosomal cysteine proteases 755176
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.16malfunction cathepsin H-deficient mice show no gross phenotype and their development is normal without growth retardation. Broncho-alveolar lavage from cathepsin H-deficient mice contain lower levels of pulmonary surfactant protein B 718296
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.16malfunction knockout of the cathepsin H gene results in 50% reduction of (Met)enkephalin in mouse brain. Cathepsin H deficient mice also show a substantial 80% decrease in galanin peptide neurotransmitter levels in brain 732360
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.16malfunction loss of CTSH inhibits filaggrin processing, but not expression, and impairs epidermal barrier function, evidence for compensation in CTSH knockout 753961
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.16malfunction lymphocytes deficient in CatH are still capable of generating active granzyme B. CatH-deficient mice do not show a gross morphological phenotype and no impairment of reproductive capacity or breeding behavior or nursing 709114
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.16malfunction reduced filaggrin processing and impaired epidermal barrier in CTSH-deficient mouse skin, histology of Ctsh-/-, Ctsh+/-, and wild-type mouse neonatal skin, overview. Loss of CTSH increases skin macrophage counts, mast cell degranulation, and proinflammatory molecule expression. Loss of CTSH inhibits filaggrin processing, but not expression, and impairs epidermal barrier function, evidence for compensation in CTSH knockout -, 753961
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.16malfunction specific inhibition of cathepsin H increases the activation of alphabeta3-integrin on PC-3 cells 732111
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.16metabolism phosphoinositide 3-kinase signaling through AKT1 is required for the proteolytic processing of filaggrin during late epidermal terminal differentiation -, 753961
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.16more the catalytic triad residues Cys26, His166 and Asn186 of procathepsin H reside in the active site cleft 755176
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.16physiological function CatB3 is a major protease antigen in Fasciola gigantica metacercariae and newly excysted juveniles 707007
Results 1 - 10 of 15 > >>