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Results 1 - 6 of 6
EC Number
General Information
Commentary
Reference
physiological function
insertion of a bat SARS-CoV PLP into the SARS-CoV genome. The resulting virus replicates like SARS-CoV in Vero cells but is suppressed in IFN competent MA-104 (3.7fold), Calu-3 (2.6fold) and human airway epithelial cells (10.3fold). A protease-independent, anti-IFN function exists in SARS-CoV, but not in a SARS-related, bat-borne virus
physiological function
MERS PLpro is both a deubiquitinating and a deISGylating enzyme (ISG15 i.e. ubiquitin-like modifier interferon stimulated gene 15). MERS PLpro shows broad linkage specificity for the cleavage of polyUb chains and cleaves polyUb chains one ubiquitin at a time. Comparison with SARS PLpro
physiological function
PL1 can suppress the IFN-beta expression and inhibit the nuclear translocation of interferon regulatory factor 3.The ability to antagonize IFN-beta production is dependent on the intact catalytic activity of PL1. PL1 exerts deubiquitinase activity which strongly inhibits the retinoic acid-induced gene I- and stimulator of interferon gene-dependent IFN expression
physiological function
protease PLpro dose- and time-dependently up-regulates TGF-beta1 and vimentin in A-549 cellsThe TGF-beta1 promoter region between -175 to -60, the Egr-1 binding site, is responsible for TGF-beta1 promoter activation induced by PLpro. PLpro triggers nuclear translocation of Egr-1. In a mouse model with a direct pulmonary injection, PLpro stimulates macrophage infiltration into lung, up-regulating Egr-1, TSP-1, TGF-beta1 and vimentin expression in lung tissues
physiological function
SARS PLpro prefers to cleave Lys48-linked polyUb chains and needs a di-Ub moiety as a minimal recognition element. Comaprison with MERS PLpro enzyme
physiological function
SARS-CoV and MERS-CoV PLpros are both capable of fully processing proISG15 from human, mouse, camel and bat within 60 minutes. SARS PLpro is also able to fully process proISG15 from sheep and shrew within that same time but it has little to no activity against jackfish proISG15
Results 1 - 6 of 6