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the enzyme is one of three distinct viral proteases (PLP1, PLP2 and 3CLpro) involved in processing of the replicase polyprotein
polyubiquitin + H2O
the enzyme cleaves Lys48- and Lys63-linked polyubiquitin to monoubiquitin but not linear polyubiquitin
replicase polyprotein + H2O
PLP2 cleaves a substrate encoding the first predicted membrane-spanning domain, MP1, of the replicase polyprotein. Processing the replicase polyprotein at this site generates the p150 replicase intermediate that is likely critical for embedding the replicase complex into cellular membranes. The enzyme acts efficiently in trans
ubiquitin + H2O
the enzyme cleaves the LRGG tail of ubiquitin
ubiquitin + H2O
the enzyme processes both K-48 and K-63 linked polyubiquitin chains
ubiquitinated RIG-I + H2O
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ubiquitinated STING + H2O
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