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EC Number Localization Commentary GeneOntology No. Reference
Display the word mapDisplay the reaction diagram Show all sequences 3.4.17.23cell membrane - - 708649
Display the word mapDisplay the reaction diagram Show all sequences 3.4.17.23cell surface - GO:0009986 AmiGO QuickGO 707074
Display the word mapDisplay the reaction diagram Show all sequences 3.4.17.23cell surface cell-surface non-raft protein with the extracellular N-terminal and intracellular C-terminal domains. Binding to SARS-CoV-2 protein S induces the ACE2 internalization GO:0009986 AmiGO QuickGO 762787
Display the word mapDisplay the reaction diagram Show all sequences 3.4.17.23cytoplasm - GO:0005737 AmiGO QuickGO 710171
Display the word mapDisplay the reaction diagram Show all sequences 3.4.17.23cytoplasm ACE2 exists as bothmembrane bound and soluble forms, the latter being generated by proteolytic cleavage of the ectodomain by the tumor necrosis factor convertase ADAM17 GO:0005737 AmiGO QuickGO 694170
Display the word mapDisplay the reaction diagram Show all sequences 3.4.17.23membrane - GO:0016020 AmiGO QuickGO 658459, 659147, 679300, 679706, 679708, 680388, 710171
Display the word mapDisplay the reaction diagram Show all sequences 3.4.17.23membrane ACE 2 is shedded GO:0016020 AmiGO QuickGO 707074
Display the word mapDisplay the reaction diagram Show all sequences 3.4.17.23membrane ACE2 also undergoes phorbol-12-myristate-13-acetate-inducible ectodomain shedding from the membrane GO:0016020 AmiGO QuickGO 679705
Display the word mapDisplay the reaction diagram Show all sequences 3.4.17.23membrane ACE2 exists as bothmembrane bound and soluble forms, the latter being generated by proteolytic cleavage of the ectodomain by the tumor necrosis factor convertase ADAM17 GO:0016020 AmiGO QuickGO 694170
Display the word mapDisplay the reaction diagram Show all sequences 3.4.17.23membrane ACE2 is a type I membrane-anchored protein with a catalytically active ectodomain, that undergoes shedding GO:0016020 AmiGO QuickGO 707055
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