3.4.22.14	actinidain	-	
3.4.22.39	adenain	-	
3.4.22.B76	Allium alpha-fibrinogenase AFTEII	preliminary BRENDA-supplied EC number	
3.4.22.31	Ananain	-	
3.4.22.7	asclepain	-	
3.4.22.40	bleomycin hydrolase	-	
3.4.22.5	bromelain (juice)	transferred to EC 3.4.22.33	
3.4.22.4	bromelain (stem)	transferred to EC 3.4.22.32, EC  3.4.22.33	
3.4.22.66	calicivirin	-	
3.4.22.17	calpain	transferred to EC 3.4.22.52 and EC 3.4.22.53	
3.4.22.B30	calpain 10	preliminary BRENDA-supplied EC number	
3.4.22.B31	calpain 11	preliminary BRENDA-supplied EC number	
3.4.22.B32	calpain 12	preliminary BRENDA-supplied EC number	
3.4.22.B35	calpain 15	preliminary BRENDA-supplied EC number	
3.4.22.B24	calpain 4	preliminary BRENDA-supplied EC number	
3.4.22.B25	calpain 5	preliminary BRENDA-supplied EC number	
3.4.22.B26	calpain 6	preliminary BRENDA-supplied EC number	
3.4.22.B27	calpain 7	preliminary BRENDA-supplied EC number	
3.4.22.B28	calpain 8	preliminary BRENDA-supplied EC number	
3.4.22.B29	calpain 9	preliminary BRENDA-supplied EC number	
3.4.22.B36	calpain A	preliminary BRENDA-supplied EC number	
3.4.22.B37	calpain B	preliminary BRENDA-supplied EC number	
3.4.22.B38	calpain C	preliminary BRENDA-supplied EC number	
3.4.22.52	calpain-1	-	
3.4.22.53	calpain-2	-	
3.4.22.54	calpain-3	-	
3.4.22.26	cancer procoagulant	-	
3.4.22.30	Caricain	-	
3.4.22.36	caspase-1	-	
3.4.22.63	caspase-10	-	
3.4.22.64	caspase-11	-	
3.4.22.B66	caspase-12	preliminary BRENDA-supplied EC number	
3.4.22.55	caspase-2	-	
3.4.22.56	caspase-3	-	
3.4.22.57	caspase-4	-	
3.4.22.58	caspase-5	-	
3.4.22.59	caspase-6	-	
3.4.22.60	caspase-7	-	
3.4.22.61	caspase-8	-	
3.4.22.62	caspase-9	-	
3.4.22.1	cathepsin B	-	
3.4.22.B6	cathepsin B-like protease	preliminary BRENDA-supplied EC number	
3.4.22.41	cathepsin F	-	
3.4.22.16	cathepsin H	-	
3.4.22.38	cathepsin K	-	
3.4.22.15	cathepsin L	-	
3.4.22.B49	cathepsin L1	preliminary BRENDA-supplied EC number	
3.4.22.B60	cathepsin L2	preliminary BRENDA-supplied EC number	
3.4.22.B62	cathepsin L3	preliminary BRENDA-supplied EC number	
3.4.22.B61	cathepsin L5	preliminary BRENDA-supplied EC number	
3.4.22.42	cathepsin O	-	
3.4.22.B65	cathepsin P	preliminary BRENDA-supplied EC number	
3.4.22.27	cathepsin S	-	
3.4.22.24	cathepsin T	-	
3.4.22.43	cathepsin V	-	
3.4.22.6	chymopapain	-	
3.4.22.8	clostripain	-	
3.4.22.B5	CPB protease	preliminary BRENDA-supplied EC number	
3.4.22.51	cruzipain	-	
3.4.22.20	dinorphin-converting enzyme	deleted	
3.4.22.B68	EhCP4 proteinase	preliminary BRENDA-supplied EC number	
3.4.22.19	endo-oligopeptidase	transferred to EC 3.4.24.15	
3.4.22.B78	endopepidase PH1704	preliminary BRENDA-supplied EC number	
3.4.22.B69	falcipain-2	preliminary BRENDA-supplied EC number	
3.4.22.3	ficain	-	
3.4.22.33	Fruit bromelain	-	
3.4.22.12	gamma-glutamyl hydrolase	transferred to EC 3.4.19.9	
3.4.22.47	gingipain K	-	
3.4.22.37	gingipain R	-	
3.4.22.25	glycyl endopeptidase	-	
3.4.22.45	helper-component proteinase	-	
3.4.22.35	Histolysain	-	
3.4.22.11	insulinase	transferred to EC 3.4.99.45	
3.4.22.46	L-peptidase	-	
3.4.22.34	Legumain	-	
3.4.22.B47	legume cysteine endopeptidase	preliminary BRENDA-supplied EC number	
3.4.22.B79	nsP2 protease	preliminary BRENDA-supplied EC number	
3.4.22.44	nuclear-inclusion-a endopeptidase	-	
3.4.22.2	papain	-	
3.4.22.B14	papain-like proteinase 1	preliminary BRENDA-supplied EC number	
3.4.22.B50	papain-like proteinase 2	preliminary BRENDA-supplied EC number	
3.4.22.65	peptidase 1 (mite)	-	
3.4.22.B20	PfpI endopeptidase	preliminary BRENDA-supplied EC number	
3.4.22.29	picornain 2A	-	
3.4.22.28	picornain 3C	-	
3.4.22.18	prolyl endopeptidase (thiol-dependent)	transferred to EC 3.4.21.26	
3.4.22.B15	rabbit hemorrhagic disease virus 3C-like protease	preliminary BRENDA-supplied EC number	
3.4.22.69	SARS coronavirus main proteinase	-	
3.4.22.B80	SARS-CoV papain-like protease	preliminary BRENDA-supplied EC number	
3.4.22.B70	SENP1 peptidase	preliminary BRENDA-supplied EC number	
3.4.22.B71	SENP2 peptidase	preliminary BRENDA-supplied EC number	
3.4.22.B72	SENP3 peptidase	preliminary BRENDA-supplied EC number	
3.4.22.B73	SENP5 peptidase	preliminary BRENDA-supplied EC number	
3.4.22.B74	SENP6 peptidase	preliminary BRENDA-supplied EC number	
3.4.22.B75	SENP7 peptidase	preliminary BRENDA-supplied EC number	
3.4.22.49	separase	-	
3.4.22.70	sortase A	-	
3.4.22.71	sortase B	-	
3.4.22.B63	sortase C	preliminary BRENDA-supplied EC number	
3.4.22.B64	sortase D	preliminary BRENDA-supplied EC number	
3.4.22.48	staphopain	-	
3.4.22.13	staphylococcal cysteine proteinase	deleted	
3.4.22.32	Stem bromelain	-	
3.4.22.10	streptopain	-	
3.4.22.B77	Sulfolobus solfataricus peptidase	preliminary BRENDA-supplied EC number	
3.4.22.B8	Tpr proteinase (Porphyromonas gingivalis)	preliminary BRENDA-supplied EC number	
3.4.22.68	Ulp1 peptidase	-	
3.4.22.B67	Ulp2 peptidase	preliminary BRENDA-supplied EC number	
3.4.22.50	V-cath endopeptidase	-	
3.4.22.B1	vignain	preliminary BRENDA-supplied EC number	
3.4.22.22	yeast cysteine proteinase D	transferred to EC 3.4.24.37	
3.4.22.21	yeast cysteine proteinase E	transferred to EC 3.4.99.46	
3.4.22.23	yeast cysteine proteinase F	transferred to EC 3.4.21.61	
3.4.22.9	yeast proteinase B	transferred to EC 3.4.21.48	
3.4.22.B19	YopJ protease	preliminary BRENDA-supplied EC number	
3.4.22.67	zingipain	-