3.4.22.52 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7988478&form=6&db=m 1,25-Dihydroxyvitamin D3 increases the cellular content of the calcium-activated neutral protease mu-calpain in renal cell carcinoma. causal interaction,ongoing research,unassigned 1,4,0 3.4.22.52 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7988478&form=6&db=m 1,25-Dihydroxyvitamin D3 increases the cellular content of the calcium-activated neutral protease mu-calpain in renal cell carcinoma. causal interaction,ongoing research,unassigned 1,4,0 3.4.22.52 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28709827&form=6&db=m 20(R)-Ginsenoside Rg3 protects SH-SY5Y cells against apoptosis induced by oxygen and glucose deprivation/reperfusion. ongoing research,unassigned 2,0 3.4.22.52 Tauopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29126071&form=6&db=m ?-Lipoic acid improves abnormal behavior by mitigation of oxidative stress, inflammation, ferroptosis, and tauopathy in P301S Tau transgenic mice. causal interaction,unassigned 3,0 3.4.22.52 Multiple Endocrine Neoplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9888998&form=6&db=m A 500-kb sequence-ready cosmid contig and transcript map of the MEN1 region on 11q13. ongoing research,unassigned 2,0 3.4.22.52 Multiple Endocrine Neoplasia Type 1 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9888998&form=6&db=m A 500-kb sequence-ready cosmid contig and transcript map of the MEN1 region on 11q13. ongoing research,unassigned 2,0 3.4.22.52 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9888998&form=6&db=m A 500-kb sequence-ready cosmid contig and transcript map of the MEN1 region on 11q13. ongoing research,unassigned 2,0 3.4.22.52 Leukemia, Myeloid, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27294874&form=6&db=m A calcium- and calpain-dependent pathway determines the response to lenalidomide in myelodysplastic syndromes. causal interaction,unassigned 1,0 3.4.22.52 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9070759&form=6&db=m A calpain inhibitor attenuates cortical cytoskeletal protein loss after experimental traumatic brain injury in the rat. causal interaction,ongoing research,therapeutic application,unassigned 1,2,4,0 3.4.22.52 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1426051&form=6&db=m A comparison of the intracellular distribution of mu-calpain, m-calpain, and calpastatin in proliferating human A431 cells. unassigned - 3.4.22.52 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21569760&form=6&db=m A high fat diet-induced impaired glucose metabolism in mice with targeted deletion of calpain in osteoblasts. diagnostic usage,unassigned 2,0 3.4.22.52 Ataxia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25998802&form=6&db=m A KCNJ10 mutation previously identified in the Russell group of terriers also occurs in Smooth-Haired Fox Terriers with hereditary ataxia and in related breeds. causal interaction,diagnostic usage,unassigned 4,1,0 3.4.22.52 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18055788&form=6&db=m A key role for calpains in retinal ganglion cell death. causal interaction,therapeutic application,unassigned 1,1,0 3.4.22.52 Cerebellar Ataxia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31231303&form=6&db=m A Novel CAPN1 Mutation Causes a Pure Hereditary Spastic Paraplegia in an Italian Family. causal interaction,unassigned 4,0 3.4.22.52 Spastic Paraplegia, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31231303&form=6&db=m A Novel CAPN1 Mutation Causes a Pure Hereditary Spastic Paraplegia in an Italian Family. causal interaction,unassigned 4,0 3.4.22.52 Spinocerebellar Ataxias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31231303&form=6&db=m A Novel CAPN1 Mutation Causes a Pure Hereditary Spastic Paraplegia in an Italian Family. causal interaction,unassigned 4,0 3.4.22.52 Spastic Paraplegia, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30938113&form=6&db=m A Novel Homozygous CAPN1 Pathogenic Variant in a Chinese Patient with Pure Hereditary Spastic Paraplegia. unassigned - 3.4.22.52 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34031057&form=6&db=m A Novel Topical Fluorescent Probe for Detection of Glioblastoma. unassigned - 3.4.22.52 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31262726&form=6&db=m A positive feedback loop involving nuclear factor IB and calpain 1 suppresses glioblastoma cell migration. unassigned - 3.4.22.52 Myalgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24664555&form=6&db=m A post-transcriptional mechanism regulates calpastatin expression in bovine skeletal muscle. ongoing research,unassigned 1,0 3.4.22.52 Muscular Atrophy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34319828&form=6&db=m A semiautomated measurement of muscle fiber size using the Imaris software. causal interaction,unassigned 2,0 3.4.22.52 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25476568&form=6&db=m Accumulation of ?-synuclein in dementia with Lewy bodies is associated with decline in the ?-synuclein-degrading enzymes kallikrein-6 and calpain-1. diagnostic usage,ongoing research,unassigned 3,1,0 3.4.22.52 Dementia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25476568&form=6&db=m Accumulation of ?-synuclein in dementia with Lewy bodies is associated with decline in the ?-synuclein-degrading enzymes kallikrein-6 and calpain-1. diagnostic usage,ongoing research,unassigned 3,1,0 3.4.22.52 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27880847&form=6&db=m Activation of Both the Calpain and Ubiquitin-Proteasome Systems Contributes to Septic Cardiomyopathy through Dystrophin Loss/Disruption and mTOR Inhibition. causal interaction,diagnostic usage,therapeutic application,unassigned 2,3,1,0 3.4.22.52 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9296555&form=6&db=m Active site-directed antibodies identify calpain II as an early-appearing and pervasive component of neurofibrillary pathology in Alzheimer's disease. causal interaction,ongoing research,unassigned 3,1,0 3.4.22.52 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2998702&form=6&db=m Age-related changes of calpain II and alpha-crystallin in the lens of hereditary cataract (Nakano) mouse. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 3.4.22.52 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23831472&form=6&db=m ALLN hinders HCT116 tumor growth through Bax-dependent apoptosis. causal interaction,unassigned 4,0 3.4.22.52 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23831472&form=6&db=m ALLN hinders HCT116 tumor growth through Bax-dependent apoptosis. causal interaction,unassigned 4,0 3.4.22.52 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24929209&form=6&db=m Alpha II Spectrin breakdown products in immature Sprague Dawley rat hippocampus and cortex after traumatic brain injury. unassigned - 3.4.22.52 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8395520&form=6&db=m alpha-Crystallin chaperone activity is reduced by calpain II in vitro and in selenite cataract. ongoing research,unassigned 3,0 3.4.22.52 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1848210&form=6&db=m Amelioration of cataracts and proteolysis in cultured lenses by cysteine protease inhibitor E64. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 3.4.22.52 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16703260&form=6&db=m Amino acid starvation induced autophagic cell death in PC-12 cells: evidence for activation of caspase-3 but not calpain-1. ongoing research,unassigned 2,0 3.4.22.52 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32039889&form=6&db=m An unexpected co-crystal structure of the calpain PEF(S) domain with Hfq reveals a potential chaperone function of Hfq. causal interaction,therapeutic application,unassigned 3,4,0 3.4.22.52 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32039889&form=6&db=m An unexpected co-crystal structure of the calpain PEF(S) domain with Hfq reveals a potential chaperone function of Hfq. causal interaction,therapeutic application,unassigned 3,4,0 3.4.22.52 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32039889&form=6&db=m An unexpected co-crystal structure of the calpain PEF(S) domain with Hfq reveals a potential chaperone function of Hfq. causal interaction,therapeutic application,unassigned 3,4,0 3.4.22.52 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12851726&form=6&db=m Association of mitochondrial calpain activation with increased expression and autolysis of calpain small subunit in an early stage of apoptosis. causal interaction,ongoing research,therapeutic application,unassigned 1,3,2,0 3.4.22.52 Coinfection http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8670065&form=6&db=m Biologically active monomeric and heterodimeric recombinant human calpain I produced using the baculovirus expression system. ongoing research,unassigned 1,0 3.4.22.52 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8670065&form=6&db=m Biologically active monomeric and heterodimeric recombinant human calpain I produced using the baculovirus expression system. ongoing research,unassigned 1,0 3.4.22.52 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8522983&form=6&db=m Brain mu-calpain autolysis during global cerebral ischemia. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 3.4.22.52 Heart Arrest http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8522983&form=6&db=m Brain mu-calpain autolysis during global cerebral ischemia. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 3.4.22.52 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28267204&form=6&db=m C-terminal truncation of GSK-3? enhances its dephosphorylation by PP2A. unassigned - 3.4.22.52 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15225813&form=6&db=m Calcium as a mediator of 1,25-dihydroxyvitamin D3-induced apoptosis. causal interaction,therapeutic application,unassigned 4,2,0 3.4.22.52 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12393065&form=6&db=m Calcium channel blockade limits transcriptional, translational and functional up-regulation of the cardiac calpain system after myocardial infarction. diagnostic usage,therapeutic application,unassigned 3,2,0 3.4.22.52 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12393065&form=6&db=m Calcium channel blockade limits transcriptional, translational and functional up-regulation of the cardiac calpain system after myocardial infarction. diagnostic usage,therapeutic application,unassigned 3,2,0 3.4.22.52 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16081284&form=6&db=m Calcium signaling in cancer and vitamin D. therapeutic application,unassigned 2,0 3.4.22.52 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16081284&form=6&db=m Calcium signaling in cancer and vitamin D. therapeutic application,unassigned 2,0 3.4.22.52 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7847693&form=6&db=m Calcium-activated neutral proteinase (calpain) system in aging and Alzheimer's disease. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,1,0 3.4.22.52 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7847693&form=6&db=m Calcium-activated neutral proteinase (calpain) system in aging and Alzheimer's disease. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,1,0 3.4.22.52 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24670325&form=6&db=m Calcium-signal facilitates herpes simplex virus type 1 nuclear transport through slingshot 1 and calpain-1 activation. unassigned - 3.4.22.52 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18032503&form=6&db=m Calpain 1 and 2 are required for RNA replication of echovirus 1. therapeutic application,unassigned 1,0 3.4.22.52 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30683309&form=6&db=m Calpain 1 in bronchoalveolar lavage fluid is associated with poor prognosis in lepidic predominant pulmonary adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.4.22.52 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30683309&form=6&db=m Calpain 1 in bronchoalveolar lavage fluid is associated with poor prognosis in lepidic predominant pulmonary adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.4.22.52 Spinal Cord Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23102374&form=6&db=m Calpain 1 Knockdown Improves Tissue Sparing and Functional Outcomes after Spinal Cord Injury in Rats. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 3.4.22.52 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30106446&form=6&db=m Calpain 2 knockdown promotes cell apoptosis and restores gefitinib sensitivity through epidermal growth factor receptor/protein kinase B/survivin signaling. ongoing research,unassigned 4,0 3.4.22.52 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30106446&form=6&db=m Calpain 2 knockdown promotes cell apoptosis and restores gefitinib sensitivity through epidermal growth factor receptor/protein kinase B/survivin signaling. ongoing research,unassigned 4,0 3.4.22.52 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22427650&form=6&db=m Calpain 2 regulates Akt-FoxO-p27(Kip1) protein signaling pathway in mammary carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 3.4.22.52 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12070670&form=6&db=m Calpain activation in neurodegenerative diseases: confocal immunofluorescence study with antibodies specifically recognizing the active form of calpain 2. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,2,2 3.4.22.52 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17647000&form=6&db=m Calpain and caspase proteolytic markers co-localize with rat cortical neurons after exposure to methamphetamine and MDMA. diagnostic usage,ongoing research,therapeutic application,unassigned 2,2,1,0 3.4.22.52 Pleural Effusion, Malignant http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29997916&form=6&db=m Calpain and spectrin breakdown products as potential biomarkers in tuberculous pleural effusion. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,1 3.4.22.52 Tuberculosis, Pleural http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29997916&form=6&db=m Calpain and spectrin breakdown products as potential biomarkers in tuberculous pleural effusion. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,1 3.4.22.52 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27215381&form=6&db=m Calpain Genetic Disruption and HSP90 Inhibition Combine To Attenuate Mammary Tumorigenesis. causal interaction,ongoing research,therapeutic application,unassigned 2,3,4,0 3.4.22.52 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29614685&form=6&db=m Calpain I Activation Causes GLUT3 Proteolysis and Downregulation of O-GlcNAcylation in Alzheimer's Disease Brain. causal interaction,unassigned 4,0 3.4.22.52 Status Epilepticus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23212179&form=6&db=m Calpain I Activity and Its Relationship with Hippocampal Neuronal Death in Pilocarpine-Induced Status Epilepticus Rat Model. diagnostic usage,ongoing research,unassigned 1,4,0 3.4.22.52 Atrial Fibrillation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18208663&form=6&db=m Calpain I inhibition prevents atrial structural remodeling in a canine model with atrial fibrillation. ongoing research,therapeutic application,unassigned 1,2,0 3.4.22.52 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15168010&form=6&db=m Calpain I inhibitor ameliorates the indices of disease severity in a murine model of cerulein-induced acute pancreatitis. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 3.4.22.52 Pancreatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15168010&form=6&db=m Calpain I inhibitor ameliorates the indices of disease severity in a murine model of cerulein-induced acute pancreatitis. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 3.4.22.52 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2209751&form=6&db=m Calpain II in two in vivo models of sugar cataract. diagnostic usage,ongoing research,therapeutic application,unassigned 4,2,1,0 3.4.22.52 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15978171&form=6&db=m Calpain inhibitor A-558693 in experimental focal cerebral ischemia in rats. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 3.4.22.52 Neurologic Manifestations http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15715081&form=6&db=m Calpain inhibitor inhibits p35-p25-Cdk5 activation, decreases tau hyperphosphorylation, and improves neurological function after spinal cord hemisection in rats. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 3.4.22.52 Spinal Cord Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15715081&form=6&db=m Calpain inhibitor inhibits p35-p25-Cdk5 activation, decreases tau hyperphosphorylation, and improves neurological function after spinal cord hemisection in rats. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 3.4.22.52 Ototoxicity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25206508&form=6&db=m Calpain mediated cisplatin-induced ototoxicity in mice. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 3.4.22.52 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9701348&form=6&db=m Calpain mediates eukaryotic initiation factor 4G degradation during global brain ischemia. causal interaction,therapeutic application,unassigned 1,1,0 3.4.22.52 Heart Arrest http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9701348&form=6&db=m Calpain mediates eukaryotic initiation factor 4G degradation during global brain ischemia. causal interaction,therapeutic application,unassigned 1,1,0 3.4.22.52 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28302665&form=6&db=m Calpain mobilizes Atg9/Bif-1 vesicles from Golgi stacks upon autophagy induction by thapsigargin. unassigned - 3.4.22.52 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21795695&form=6&db=m Calpain protects the heart from hemodynamic stress. therapeutic application,unassigned 1,0 3.4.22.52 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19946330&form=6&db=m Calpain regulates sensitivity to trastuzumab and survival in HER2-positive breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,1,4 3.4.22.52 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26771715&form=6&db=m Calpain restrains the stem cells compartment in breast cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0 3.4.22.52 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19029949&form=6&db=m Calpain small-1 modulates Akt/FoxO3A signaling and apoptosis through PP2A. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 3.4.22.52 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30448882&form=6&db=m Calpain system protein expression and activity in ovarian cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.4.22.52 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30448882&form=6&db=m Calpain system protein expression and activity in ovarian cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.4.22.52 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22745213&form=6&db=m Calpain system protein expression in basal-like and triple-negative invasive breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,1 3.4.22.52 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22745213&form=6&db=m Calpain system protein expression in basal-like and triple-negative invasive breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,1 3.4.22.52 Machado-Joseph Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31960910&form=6&db=m Calpain-1 ablation partially rescues disease-associated hallmarks in models of Machado-Joseph disease. causal interaction,therapeutic application,unassigned 2,1,0 3.4.22.52 Blindness http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27185592&form=6&db=m Calpain-1 and calpain-2 play opposite roles in retinal ganglion cell degeneration induced by retinal ischemia/reperfusion injury. causal interaction,therapeutic application,unassigned 4,4,0 3.4.22.52 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34430716&form=6&db=m Calpain-1 C2L domain peptide protects mouse hippocampus-derived neuronal HT22 cells against glutamate-induced oxytosis. unassigned - 3.4.22.52 calpain-1 deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24760147&form=6&db=m Calpain-1 contributes to IgE-mediated mast cell activation. unassigned - 3.4.22.52 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28536704&form=6&db=m Calpain-1 Expression in Triple-Negative Breast Cancer: A Potential Prognostic Factor Independent of the Proliferative/Apoptotic Index. causal interaction,diagnostic usage,unassigned 4,4,0 3.4.22.52 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28536704&form=6&db=m Calpain-1 Expression in Triple-Negative Breast Cancer: A Potential Prognostic Factor Independent of the Proliferative/Apoptotic Index. causal interaction,diagnostic usage,unassigned 4,4,0 3.4.22.52 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21140455&form=6&db=m Calpain-1 expression is associated with relapse-free survival in breast cancer patients treated with trastuzumab following adjuvant chemotherapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 3.4.22.52 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21140455&form=6&db=m Calpain-1 expression is associated with relapse-free survival in breast cancer patients treated with trastuzumab following adjuvant chemotherapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 3.4.22.52 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24215346&form=6&db=m Calpain-1 inhibitors for selective treatment of rheumatoid arthritis: what is the future? causal interaction,therapeutic application,unassigned 4,4,0 3.4.22.52 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26496999&form=6&db=m Calpain-1 is associated with adverse relapse free survival in breast cancer: a confirmatory study. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,3,0 3.4.22.52 Anemia, Sickle Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22870887&form=6&db=m Calpain-1 knockout reveals broad effects on erythrocyte deformability and physiology. therapeutic application,unassigned 4,0 3.4.22.52 Vascular Calcification http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26047104&form=6&db=m Calpain-1 Mediated Disorder of Pyrophosphate Metabolism Contributes to Vascular Calcification Induced by oxLDL. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 3.4.22.52 Cystic Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14612448&form=6&db=m Calpain-1 regulates Bax and subsequent Smac-dependent caspase-3 activation in neutrophil apoptosis. causal interaction,unassigned 1,0 3.4.22.52 Anemia, Sickle Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29101791&form=6&db=m Calpain-1 regulates platelet function in a humanized mouse model of sickle cell disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,2 3.4.22.52 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29101791&form=6&db=m Calpain-1 regulates platelet function in a humanized mouse model of sickle cell disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,2 3.4.22.52 Pulmonary Arterial Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29101791&form=6&db=m Calpain-1 regulates platelet function in a humanized mouse model of sickle cell disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,2 3.4.22.52 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23006733&form=6&db=m Calpain-1 regulation of matrix metalloproteinase 2 activity in vascular smooth muscle cells facilitates age-associated aortic wall calcification and fibrosis. causal interaction,ongoing research,therapeutic application,unassigned 4,2,3,0 3.4.22.52 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23006733&form=6&db=m Calpain-1 regulation of matrix metalloproteinase 2 activity in vascular smooth muscle cells facilitates age-associated aortic wall calcification and fibrosis. causal interaction,ongoing research,therapeutic application,unassigned 4,2,3,0 3.4.22.52 Vascular Calcification http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23006733&form=6&db=m Calpain-1 regulation of matrix metalloproteinase 2 activity in vascular smooth muscle cells facilitates age-associated aortic wall calcification and fibrosis. causal interaction,ongoing research,therapeutic application,unassigned 4,2,3,0 3.4.22.52 Aortic Aneurysm, Abdominal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23977256&form=6&db=m Calpain-2 Compensation Promotes Angiotensin II-Induced Ascending and Abdominal Aortic Aneurysms in Calpain-1 Deficient Mice. causal interaction,ongoing research,therapeutic application,unassigned 2,2,2,0 3.4.22.52 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25150005&form=6&db=m Calpain-2 contributes to neuropathic pain following motor nerve injury via up-regulating interleukin-6 in DRG neurons. causal interaction,therapeutic application,unassigned 3,1,0 3.4.22.52 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22435971&form=6&db=m Calpain-2 expression is associated with response to platinum based chemotherapy, progression-free and overall survival in ovarian cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 3.4.22.52 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34524407&form=6&db=m Calpain-2 Specifically Cleaves Junctophilin-2 at the Same Site as Calpain-1 but with Less Efficacy. causal interaction,therapeutic application,unassigned 3,3,0 3.4.22.52 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7982901&form=6&db=m Calpain-calpastatin interactions in epidermoid carcinoma KB cells. ongoing research,unassigned 4,0 3.4.22.52 Muscle Spasticity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8410223&form=6&db=m Calpain-calpastatin system of canine basilar artery in vasospasm. diagnostic usage,unassigned 2,0 3.4.22.52 Synucleinopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17456777&form=6&db=m Calpain-cleavage of alpha-synuclein: connecting proteolytic processing to disease-linked aggregation. causal interaction,unassigned 2,0 3.4.22.52 Meningioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11745202&form=6&db=m Calpain-dependent proteolysis of merlin occurs by oxidative stress in meningiomas: a novel hypothesis of tumorigenesis. causal interaction,therapeutic application,unassigned 4,1,0 3.4.22.52 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12121983&form=6&db=m Calpain-mediated X-linked inhibitor of apoptosis degradation in neutrophil apoptosis and its impairment in chronic neutrophilic leukemia. causal interaction,therapeutic application,unassigned 4,3,0 3.4.22.52 Leukemia, Neutrophilic, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12121983&form=6&db=m Calpain-mediated X-linked inhibitor of apoptosis degradation in neutrophil apoptosis and its impairment in chronic neutrophilic leukemia. causal interaction,therapeutic application,unassigned 4,3,0 3.4.22.52 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9160241&form=6&db=m Calpains and calpastatin in SH-SY5Y neuroblastoma cells during retinoic acid-induced differentiation and neurite outgrowth: comparison with the human brain calpain system. diagnostic usage,ongoing research,unassigned 3,4,0 3.4.22.52 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12063299&form=6&db=m Calpains and cytokines in fibrillating human atria. ongoing research,unassigned 1,0 3.4.22.52 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17151322&form=6&db=m Calpains and their multiple roles in diabetes mellitus. causal interaction,ongoing research,unassigned 2,1,0 3.4.22.52 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17151322&form=6&db=m Calpains and their multiple roles in diabetes mellitus. causal interaction,ongoing research,unassigned 2,1,0 3.4.22.52 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22581845&form=6&db=m Calpains, mitochondria, and apoptosis. therapeutic application,unassigned 1,0 3.4.22.52 Spastic Paraplegia, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32352326&form=6&db=m CAPN1 and hereditary spastic paraplegia: a novel variant in an Iranian family and overview of the genotype-phenotype correlation. unassigned - 3.4.22.52 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30131853&form=6&db=m CAPN1 is a novel binding partner and regulator of the tumor suppressor NF1 in melanoma. causal interaction,therapeutic application,unassigned 4,4,0 3.4.22.52 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30131853&form=6&db=m CAPN1 is a novel binding partner and regulator of the tumor suppressor NF1 in melanoma. causal interaction,therapeutic application,unassigned 4,4,0 3.4.22.52 Ataxia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28321562&form=6&db=m CAPN1 mutations are associated with a syndrome of combined spasticity and ataxia. causal interaction,unassigned 4,0 3.4.22.52 Ataxia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29678961&form=6&db=m CAPN1 mutations broadening the hereditary spastic paraplegia/spinocerebellar ataxia phenotype. unassigned - 3.4.22.52 Muscle Spasticity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29678961&form=6&db=m CAPN1 mutations broadening the hereditary spastic paraplegia/spinocerebellar ataxia phenotype. unassigned - 3.4.22.52 Ataxia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30572172&form=6&db=m CAPN1 mutations: Expanding the CAPN1-related phenotype: From hereditary spastic paraparesis to spastic ataxia. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 3.4.22.52 Muscle Spasticity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30572172&form=6&db=m CAPN1 mutations: Expanding the CAPN1-related phenotype: From hereditary spastic paraparesis to spastic ataxia. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 3.4.22.52 Paraparesis, Spastic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30572172&form=6&db=m CAPN1 mutations: Expanding the CAPN1-related phenotype: From hereditary spastic paraparesis to spastic ataxia. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 3.4.22.52 Paraplegia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30572172&form=6&db=m CAPN1 mutations: Expanding the CAPN1-related phenotype: From hereditary spastic paraparesis to spastic ataxia. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 3.4.22.52 Spastic Paraplegia, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30572172&form=6&db=m CAPN1 mutations: Expanding the CAPN1-related phenotype: From hereditary spastic paraparesis to spastic ataxia. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 3.4.22.52 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32395869&form=6&db=m CAPN1 promotes malignant behavior and erlotinib resistance mediated by phosphorylation of c-Met and PIK3R2 via degrading PTPN1 in lung adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,1,3 3.4.22.52 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32395869&form=6&db=m CAPN1 promotes malignant behavior and erlotinib resistance mediated by phosphorylation of c-Met and PIK3R2 via degrading PTPN1 in lung adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,1,3 3.4.22.52 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32395869&form=6&db=m CAPN1 promotes malignant behavior and erlotinib resistance mediated by phosphorylation of c-Met and PIK3R2 via degrading PTPN1 in lung adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,1,3 3.4.22.52 Paraplegia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31355030&form=6&db=m CAPN1 Variants as Cause of Hereditary Spastic Paraplegia Type 76. causal interaction,therapeutic application,unassigned 4,1,0 3.4.22.52 Spastic Paraplegia, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31355030&form=6&db=m CAPN1 Variants as Cause of Hereditary Spastic Paraplegia Type 76. causal interaction,therapeutic application,unassigned 4,1,0 3.4.22.52 Hepatitis B http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31680308&form=6&db=m CAPN2 acts as an indicator of hepatitis B virus to induce hepatic fibrosis. diagnostic usage,therapeutic application,unassigned 2,1,0 3.4.22.52 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30655802&form=6&db=m Capn4 regulates migration and invasion of ovarian carcinoma cells via targeting osteopontin-mediated PI3K/AKT signaling pathway. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 3.4.22.52 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30655802&form=6&db=m Capn4 regulates migration and invasion of ovarian carcinoma cells via targeting osteopontin-mediated PI3K/AKT signaling pathway. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 3.4.22.52 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10818755&form=6&db=m Casein zymogram assessment of mu-calpain and m-calpain activity after traumatic brain injury in the rat in vivo. ongoing research,therapeutic application,unassigned 2,1,0 3.4.22.52 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32038556&form=6&db=m CD163?SRCR5 MARC-145 Cells Resist PRRSV-2 Infection via Inhibiting Virus Uncoating, Which Requires the Interaction of CD163 With Calpain 1. unassigned - 3.4.22.52 Muscular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30912963&form=6&db=m Cellular and molecular signatures of alcohol-induced myopathy in women. causal interaction,unassigned 3,0 3.4.22.52 Malaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17359359&form=6&db=m Cerebral calpain in fatal falciparum malaria. causal interaction,ongoing research,therapeutic application,unassigned 2,4,1,0 3.4.22.52 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9196396&form=6&db=m Changes in calpain II mRNA in young rat lens during maturation and cataract formation. causal interaction,diagnostic usage,ongoing research,unassigned 2,1,3,0 3.4.22.52 Kidney Calculi http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30508278&form=6&db=m Characterizations of HSP90-Interacting Complex in Renal Cells Using Tandem Affinity Purification and Its Potential Role in Kidney Stone Formation. causal interaction,unassigned 4,0 3.4.22.52 Anaphylaxis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8434317&form=6&db=m Chemonucleolysis with calpain I in rabbits. unassigned - 3.4.22.52 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16091365&form=6&db=m Chlortetracycline and demeclocycline inhibit calpains and protect mouse neurons against glutamate toxicity and cerebral ischemia. therapeutic application,unassigned 4,0 3.4.22.52 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10415614&form=6&db=m Chronic administration of UK-114, a multifunctional emerging protein, modulates the Th1/Th2 cytokine pattern and experimental autoimmune diseases. ongoing research,therapeutic application,unassigned 3,3,0 3.4.22.52 Cardiomyopathy, Alcoholic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21833537&form=6&db=m Chronic alcohol intake-induced oxidative stress and apoptosis: role of CYP2E1 and calpain-1 in alcoholic cardiomyopathy. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0 3.4.22.52 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28089626&form=6&db=m Cisplatin Induces Apoptosis Through the Endoplasmic Reticulum-mediated, Calpain 1 Pathway in Triple-negative Breast Cancer Cells. therapeutic application,unassigned 1,0 3.4.22.52 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34381117&form=6&db=m Cleavage and activation of LIM kinase 1 as a novel mechanism for calpain 2-mediated regulation of nuclear dynamics. ongoing research,unassigned 4,0 3.4.22.52 Cholesteatoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8763371&form=6&db=m Clinical and biochemical studies of bone destruction in cholesteatoma. ongoing research,unassigned 3,0 3.4.22.52 Spastic Paraplegia, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30198554&form=6&db=m Clinical aspects of hereditary spastic paraplegia 76 and novel CAPN1 mutations. causal interaction,diagnostic usage,unassigned 1,3,0 3.4.22.52 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26893741&form=6&db=m Clinical correlation of calpain-1 and glypican-3 expression with gallbladder carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,1,0 3.4.22.52 Cholecystitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26893741&form=6&db=m Clinical correlation of calpain-1 and glypican-3 expression with gallbladder carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,1,0 3.4.22.52 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26893741&form=6&db=m Clinical correlation of calpain-1 and glypican-3 expression with gallbladder carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,1,0 3.4.22.52 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31243108&form=6&db=m Comparative Proteome Profiling and Mutant Protein Identification in Metastatic Prostate Cancer Cells by Quantitative Mass Spectrometry-based Proteogenomics. diagnostic usage,unassigned 3,0 3.4.22.52 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1440613&form=6&db=m Comparison of cell-permeable calpain inhibitors and E64 in reduction of cataract in cultured rat lenses. causal interaction,ongoing research,therapeutic application,unassigned 2,2,4,0 3.4.22.52 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28927135&form=6&db=m Comparison of the protein expression of calpain-1, calpain-2, calpastatin and calmodulin between gastric cancer and normal gastric mucosa. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,3 3.4.22.52 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30863494&form=6&db=m Correction: CAPN1 is a novel binding partner and regulator of the tumor suppressor NF1 in melanoma. causal interaction,unassigned 2,0 3.4.22.52 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30863494&form=6&db=m Correction: CAPN1 is a novel binding partner and regulator of the tumor suppressor NF1 in melanoma. causal interaction,unassigned 2,0 3.4.22.52 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12569370&form=6&db=m Cyclin E in breast tumors is cleaved into its low molecular weight forms by calpain. diagnostic usage,therapeutic application,unassigned 3,1,0 3.4.22.52 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17963167&form=6&db=m Cysteine and serine proteases of synovial tissue in rheumatoid arthritis and osteoarthritis. diagnostic usage,ongoing research,unassigned 1,3,0 3.4.22.52 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17963167&form=6&db=m Cysteine and serine proteases of synovial tissue in rheumatoid arthritis and osteoarthritis. diagnostic usage,ongoing research,unassigned 1,3,0 3.4.22.52 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26713267&form=6&db=m Cysteine proteases as therapeutic targets: does selectivity matter? A systematic review of calpain and cathepsin inhibitors. therapeutic application,unassigned 4,0 3.4.22.52 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11236903&form=6&db=m Dantrolene reduces serum TNFalpha and corticosterone levels and muscle calcium, calpain gene expression, and protein breakdown in septic rats. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 3.4.22.52 Ataxia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27320912&form=6&db=m Defects in the CAPN1 Gene Result in Alterations in Cerebellar Development and Cerebellar Ataxia in Mice and Humans. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 3.4.22.52 Cerebellar Ataxia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27320912&form=6&db=m Defects in the CAPN1 Gene Result in Alterations in Cerebellar Development and Cerebellar Ataxia in Mice and Humans. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 3.4.22.52 Spinocerebellar Ataxias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27320912&form=6&db=m Defects in the CAPN1 Gene Result in Alterations in Cerebellar Development and Cerebellar Ataxia in Mice and Humans. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 3.4.22.52 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11264351&form=6&db=m Degradation of p21cip1 in cells productively infected with human cytomegalovirus. causal interaction,therapeutic application,unassigned 3,1,0 3.4.22.52 Spinal Cord Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16847592&form=6&db=m Degradation of spectrin via calpains in the ventral horn after transient spinal cord ischemia in rabbits. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 3.4.22.52 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27057539&form=6&db=m Dehydroabietic Acid Derivative QC4 Induces Gastric Cancer Cell Death via Oncosis and Apoptosis. ongoing research,unassigned 3,0 3.4.22.52 Endotoxemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26246018&form=6&db=m Deletion of capn4 Protects the Heart Against Endotoxemic Injury by Preventing ATP Synthase Disruption and Inhibiting Mitochondrial Superoxide Generation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 3.4.22.52 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32328086&form=6&db=m Deletion of the Capn1 Gene Results in Alterations in Signaling Pathways Related to Alzheimer's Disease, Protein Quality Control and Synaptic Plasticity in Mouse Brain. causal interaction,diagnostic usage,unassigned 4,1,0 3.4.22.52 Brain Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32328086&form=6&db=m Deletion of the Capn1 Gene Results in Alterations in Signaling Pathways Related to Alzheimer's Disease, Protein Quality Control and Synaptic Plasticity in Mouse Brain. causal interaction,diagnostic usage,unassigned 4,1,0 3.4.22.52 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19041242&form=6&db=m Design and synthesis of 4-aryl-4-oxobutanoic acid amides as calpain inhibitors. causal interaction,therapeutic application,unassigned 2,4,0 3.4.22.52 Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19041242&form=6&db=m Design and synthesis of 4-aryl-4-oxobutanoic acid amides as calpain inhibitors. causal interaction,therapeutic application,unassigned 2,4,0 3.4.22.52 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19041242&form=6&db=m Design and synthesis of 4-aryl-4-oxobutanoic acid amides as calpain inhibitors. causal interaction,therapeutic application,unassigned 2,4,0 3.4.22.52 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18396356&form=6&db=m Design and synthesis of calpain inhibitory 6-pyridone 2-carboxamide derivatives. causal interaction,therapeutic application,unassigned 2,4,0 3.4.22.52 Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18396356&form=6&db=m Design and synthesis of calpain inhibitory 6-pyridone 2-carboxamide derivatives. causal interaction,therapeutic application,unassigned 2,4,0 3.4.22.52 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18396356&form=6&db=m Design and synthesis of calpain inhibitory 6-pyridone 2-carboxamide derivatives. causal interaction,therapeutic application,unassigned 2,4,0 3.4.22.52 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23834438&form=6&db=m Design, synthesis, and optimization of novel epoxide incorporating peptidomimetics as selective calpain inhibitors. unassigned - 3.4.22.52 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27622212&form=6&db=m Differential Activation of Calpain-1 and Calpain-2 following Kainate-Induced Seizure Activity in Rats and Mice. ongoing research,unassigned 4,0 3.4.22.52 Muscular Atrophy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31219776&form=6&db=m Differential activation of the calpain system involved in individualized adaptation of different fast-twitch muscles in hibernating Daurian ground squirrels. causal interaction,therapeutic application,unassigned 3,3,0 3.4.22.52 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19732951&form=6&db=m Discrete proteolysis of neuronal calcium sensor-1 (NCS-1) by mu-calpain disrupts calcium binding. therapeutic application,unassigned 4,0 3.4.22.52 Peripheral Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19732951&form=6&db=m Discrete proteolysis of neuronal calcium sensor-1 (NCS-1) by mu-calpain disrupts calcium binding. therapeutic application,unassigned 4,0 3.4.22.52 Blister http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23935889&form=6&db=m Disruption of calcium homeostasis in cardiomyocytes underlies cardiac structural and functional changes in severe sepsis. causal interaction,ongoing research,unassigned 1,4,0 3.4.22.52 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23935889&form=6&db=m Disruption of calcium homeostasis in cardiomyocytes underlies cardiac structural and functional changes in severe sepsis. causal interaction,ongoing research,unassigned 1,4,0 3.4.22.52 Glucose Intolerance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27523632&form=6&db=m Disruption of calpain reduces lipotoxicity-induced cardiac injury by preventing endoplasmic reticulum stress. ongoing research,therapeutic application,unassigned 2,1,0 3.4.22.52 Synucleinopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12887682&form=6&db=m Distinct cleavage patterns of normal and pathologic forms of alpha-synuclein by calpain I in vitro. unassigned - 3.4.22.52 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20107320&form=6&db=m DNA damage response links calpain to cellular senescence. causal interaction,therapeutic application,unassigned 2,3,0 3.4.22.52 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28448973&form=6&db=m Downregulations of CD36 and Calpain-1, Inflammation, and Atherosclerosis by Simvastatin in Apolipoprotein E Knockout Mice. ongoing research,therapeutic application,unassigned 4,1,0 3.4.22.52 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20034566&form=6&db=m Dysfunctional mitochondria uphold calpain activation: contribution to Parkinson's disease pathology. ongoing research,unassigned 2,0 3.4.22.52 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29267303&form=6&db=m Early dystrophin loss is coincident with the transition of compensated cardiac hypertrophy to heart failure. ongoing research,unassigned 4,0 3.4.22.52 Myalgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33938371&form=6&db=m Effects of 6-(Methylsulfinyl)hexyl Isothiocyanate Ingestion on Muscle Damage after Eccentric Exercise in Healthy Males: A Pilot Placebo-Controlled Double-Blind Crossover Study. diagnostic usage,therapeutic application,unassigned 1,1,0 3.4.22.52 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22528939&form=6&db=m Effects of ARHI on cell cycle progression and apoptosis levels of breast cancer cells. ongoing research,unassigned 4,0 3.4.22.52 Myalgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26020351&form=6&db=m Effects of duration of vitamin C supplementation during the finishing period on postmortem protein degradation, tenderness, and meat color of the longissimus muscle of calf-fed steers consuming a 0.31 or 0.59% sulfur diet. therapeutic application,unassigned 1,0 3.4.22.52 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6873970&form=6&db=m Establishment, characterization, and response to cytotoxic and radiation treatment of three human melanoma cell lines. ongoing research,therapeutic application,unassigned 2,1,0 3.4.22.52 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6873970&form=6&db=m Establishment, characterization, and response to cytotoxic and radiation treatment of three human melanoma cell lines. ongoing research,therapeutic application,unassigned 2,1,0 3.4.22.52 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24440569&form=6&db=m Estrogen and pure antiestrogen fulvestrant (ICI 182 780) augment cell-matrigel adhesion of MCF-7 breast cancer cells through a novel G protein coupled estrogen receptor (GPR30)-to-calpain signaling axis. unassigned - 3.4.22.52 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7643117&form=6&db=m Eukaryotic initiation factor 4E degradation during brain ischemia. causal interaction,therapeutic application,unassigned 1,1,0 3.4.22.52 Retinitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34078571&form=6&db=m Evidence for the involvement of interleukin-1? during development of experimental cytomegalovirus retinitis in immunosuppressed mice. causal interaction,unassigned 1,0 3.4.22.52 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9629465&form=6&db=m Exploration of the importance of the P2-P3-NHCO-moiety in a potent di- or tripeptide inhibitor of calpain I: insights into the development of nonpeptidic inhibitors of calpain I. causal interaction,therapeutic application,unassigned 3,3,0 3.4.22.52 Multiple System Atrophy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29993134&form=6&db=m Exploring the putative role of kallikrein-6, calpain-1 and cathepsin-D in the proteolytic degradation of ?-synuclein in multiple system atrophy. diagnostic usage,ongoing research,unassigned 4,1,0 3.4.22.52 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9988224&form=6&db=m Expression of calpain I messenger RNA in human renal cell carcinoma: correlation with lymph node metastasis and histological type. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 3.4.22.52 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9988224&form=6&db=m Expression of calpain I messenger RNA in human renal cell carcinoma: correlation with lymph node metastasis and histological type. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 3.4.22.52 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9988224&form=6&db=m Expression of calpain I messenger RNA in human renal cell carcinoma: correlation with lymph node metastasis and histological type. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 3.4.22.52 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9988224&form=6&db=m Expression of calpain I messenger RNA in human renal cell carcinoma: correlation with lymph node metastasis and histological type. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 3.4.22.52 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9988224&form=6&db=m Expression of calpain I messenger RNA in human renal cell carcinoma: correlation with lymph node metastasis and histological type. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 3.4.22.52 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30488206&form=6&db=m Expression of Genes Encoding Cell Motility Proteins during Progression of Head and Neck Squamous Cell Carcinoma. causal interaction,diagnostic usage,unassigned 1,1,0 3.4.22.52 Adenocarcinoma, Mucinous http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30737623&form=6&db=m Expression of Syk and MAP4 proteins in ovarian cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.4.22.52 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30737623&form=6&db=m Expression of Syk and MAP4 proteins in ovarian cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.4.22.52 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23329366&form=6&db=m Expression of the calpain system is associated with poor clinical outcome in gastro-oesophageal adenocarcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 3.4.22.52 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23329366&form=6&db=m Expression of the calpain system is associated with poor clinical outcome in gastro-oesophageal adenocarcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 3.4.22.52 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33615187&form=6&db=m Extending the Calpain-Cathepsin Hypothesis to the Neurovasculature: Protection of Brain Endothelial Cells and Mice from Neurotrauma. causal interaction,therapeutic application,unassigned 3,1,0 3.4.22.52 Dementia, Vascular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33615187&form=6&db=m Extending the Calpain-Cathepsin Hypothesis to the Neurovasculature: Protection of Brain Endothelial Cells and Mice from Neurotrauma. causal interaction,therapeutic application,unassigned 3,1,0 3.4.22.52 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33615187&form=6&db=m Extending the Calpain-Cathepsin Hypothesis to the Neurovasculature: Protection of Brain Endothelial Cells and Mice from Neurotrauma. causal interaction,therapeutic application,unassigned 3,1,0 3.4.22.52 Frontotemporal Dementia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10561502&form=6&db=m FTDP-17 tau mutations decrease the susceptibility of tau to calpain I digestion. causal interaction,unassigned 3,0 3.4.22.52 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27456359&form=6&db=m Gene/protein expression of CAPN1/2-CAST system members is associated with ERK1/2 kinases activity as well as progression and clinical outcome in human laryngeal cancer. causal interaction,diagnostic usage,unassigned 1,3,0 3.4.22.52 Spastic Paraplegia, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30611022&form=6&db=m Generation of an integration-free induced pluripotent stem cell line, FJMUi001-A, from a hereditary spastic paraplegia patient carrying compound heterozygous p.P498L and p.R618W mutations in CAPN1 (SPG76). ongoing research,unassigned 4,0 3.4.22.52 Muscle Spasticity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9347985&form=6&db=m Generation of the catalytic fragment of protein kinase C alpha in spastic canine basilar artery. diagnostic usage,therapeutic application,unassigned 3,4,0 3.4.22.52 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30279968&form=6&db=m Genetic disruption of calpain-1 and calpain-2 attenuates tumorigenesis in mouse models of HER2+ breast cancer and sensitizes cancer cells to doxorubicin and lapatinib. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,2,0 3.4.22.52 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30279968&form=6&db=m Genetic disruption of calpain-1 and calpain-2 attenuates tumorigenesis in mouse models of HER2+ breast cancer and sensitizes cancer cells to doxorubicin and lapatinib. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,2,0 3.4.22.52 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30279968&form=6&db=m Genetic disruption of calpain-1 and calpain-2 attenuates tumorigenesis in mouse models of HER2+ breast cancer and sensitizes cancer cells to doxorubicin and lapatinib. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,2,0 3.4.22.52 Anemia, Sickle Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27418647&form=6&db=m Genetic inactivation of calpain-1 attenuates pain sensitivity in a humanized mouse model of sickle cell disease. ongoing research,therapeutic application,unassigned 2,2,0 3.4.22.52 Multiple Endocrine Neoplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8641689&form=6&db=m Genetic mapping studies of 40 loci and 23 cosmids in chromosome 11p13-11q13, and exclusion of mu-calpain as the multiple endocrine neoplasia type 1 gene. diagnostic usage,unassigned 1,0 3.4.22.52 Multiple Endocrine Neoplasia Type 1 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8641689&form=6&db=m Genetic mapping studies of 40 loci and 23 cosmids in chromosome 11p13-11q13, and exclusion of mu-calpain as the multiple endocrine neoplasia type 1 gene. diagnostic usage,unassigned 1,0 3.4.22.52 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8641689&form=6&db=m Genetic mapping studies of 40 loci and 23 cosmids in chromosome 11p13-11q13, and exclusion of mu-calpain as the multiple endocrine neoplasia type 1 gene. diagnostic usage,unassigned 1,0 3.4.22.52 calpain-2 deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30617810&form=6&db=m Genetic Models of Calpain Deficiency and Ectopic Expression. causal interaction,ongoing research,unassigned 3,3,0 3.4.22.52 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15358198&form=6&db=m Genistein induces Ca2+ -mediated, calpain/caspase-12-dependent apoptosis in breast cancer cells. causal interaction,therapeutic application,unassigned 1,1,0 3.4.22.52 Cystic Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24612955&form=6&db=m Genome-wide association study for poor sperm motility in Holstein-Friesian bulls. diagnostic usage,unassigned 1,0 3.4.22.52 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22623320&form=6&db=m Global profiling of proteolytically modified proteins in human metastatic hepatocellular carcinoma cell lines reveals CAPN2 centered network. ongoing research,therapeutic application,unassigned 3,1,0 3.4.22.52 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21542129&form=6&db=m Growth of hepatocellular carcinoma in the regenerating liver. causal interaction,diagnostic usage,unassigned 2,3,0 3.4.22.52 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30565085&form=6&db=m High calpain-1 expression predicts a poor clinical outcome and contributes to tumor progression in pancreatic cancer patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1 3.4.22.52 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30565085&form=6&db=m High calpain-1 expression predicts a poor clinical outcome and contributes to tumor progression in pancreatic cancer patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1 3.4.22.52 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30565085&form=6&db=m High calpain-1 expression predicts a poor clinical outcome and contributes to tumor progression in pancreatic cancer patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1 3.4.22.52 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28588694&form=6&db=m High level of calpain1 promotes cancer cell invasion and migration in oral squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4 3.4.22.52 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28588694&form=6&db=m High level of calpain1 promotes cancer cell invasion and migration in oral squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4 3.4.22.52 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28588694&form=6&db=m High level of calpain1 promotes cancer cell invasion and migration in oral squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4 3.4.22.52 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33731671&form=6&db=m hnRNPK-regulated LINC00263 promotes malignant phenotypes through miR-147a/CAPN2. causal interaction,therapeutic application,unassigned 4,1,0 3.4.22.52 Psoriasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28060905&form=6&db=m Human S100A7 Induces Mature Interleukin1? Expression by RAGE-p38 MAPK-Calpain1 Pathway in Psoriasis. causal interaction,therapeutic application,unassigned 3,1,0 3.4.22.52 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1608594&form=6&db=m Hydration and elevated calcium alone do not produce xylose nuclear cataract: role of proteolysis by calpain. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,1 3.4.22.52 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2999095&form=6&db=m Hydrolytic and autolytic behavior of two forms of calcium-activated neutral protease (CANP). unassigned - 3.4.22.52 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17446533&form=6&db=m Hyperglycemia is a major determinant of albumin permeability in diabetic microcirculation: the role of mu-calpain. causal interaction,unassigned 4,0 3.4.22.52 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20659425&form=6&db=m I-kappaBalpha depletion by transglutaminase 2 and mu-calpain occurs in parallel with the ubiquitin-proteasome pathway. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,1,0 3.4.22.52 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18496573&form=6&db=m ICP10PK inhibits calpain-dependent release of apoptosis-inducing factor and programmed cell death in response to the toxin MPP+. ongoing research,therapeutic application,unassigned 2,1,0 3.4.22.52 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15621511&form=6&db=m Identification and molecular characterization of the rainbow trout calpains (Capn1 and Capn2): their expression in muscle wasting during starvation. ongoing research,therapeutic application,unassigned 1,2,0 3.4.22.52 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17868638&form=6&db=m Identification of calpastatin and micro-calpain and studies of their association in pulmonary smooth muscle mitochondria. causal interaction,unassigned 3,0 3.4.22.52 Muscular Atrophy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29032335&form=6&db=m Identification of the optimal dose and calpain system regulation of tetramethylpyrazine on the prevention of skeletal muscle atrophy in hindlimb unloading rats. ongoing research,therapeutic application,unassigned 2,2,0 3.4.22.52 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20683020&form=6&db=m Immunhistochemical analysis for expression of calpain 1, calpain 2 and calpastatin in endometrial cancer. diagnostic usage,unassigned 1,0 3.4.22.52 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22335024&form=6&db=m Immunhistochemical analysis for expression of calpain 1, calpain 2 and calpastatin in ovarian cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,2,3 3.4.22.52 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22335024&form=6&db=m Immunhistochemical analysis for expression of calpain 1, calpain 2 and calpastatin in ovarian cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,2,3 3.4.22.52 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9804282&form=6&db=m Immunoblot analyses of the relative contributions of cysteine and aspartic proteases to neurofilament breakdown products following experimental brain injury in rats. ongoing research,unassigned 2,0 3.4.22.52 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8883097&form=6&db=m In vitro precipitation of rat lens crystallins by calpain I--a calpain requiring low amounts of calcium for activation. causal interaction,unassigned 1,0 3.4.22.52 Ventilator-Induced Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30617807&form=6&db=m In Vivo Calpain Knockdown Using Delivery of siRNA. ongoing research,unassigned 2,0 3.4.22.52 Heart Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30874894&form=6&db=m Increased calpain-1 in mitochondria induces dilated heart failure in mice: role of mitochondrial superoxide anion. causal interaction,ongoing research,therapeutic application,unassigned 4,1,3,0 3.4.22.52 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30874894&form=6&db=m Increased calpain-1 in mitochondria induces dilated heart failure in mice: role of mitochondrial superoxide anion. causal interaction,ongoing research,therapeutic application,unassigned 4,1,3,0 3.4.22.52 Ataxia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33486633&form=6&db=m Increasing involvement of CAPN1 variants in spastic ataxias and phenotype-genotype correlations. causal interaction,unassigned 1,0 3.4.22.52 Muscle Spasticity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33486633&form=6&db=m Increasing involvement of CAPN1 variants in spastic ataxias and phenotype-genotype correlations. causal interaction,unassigned 1,0 3.4.22.52 Paraplegia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33486633&form=6&db=m Increasing involvement of CAPN1 variants in spastic ataxias and phenotype-genotype correlations. causal interaction,unassigned 1,0 3.4.22.52 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22366408&form=6&db=m Induction of apoptosis in E?-myc lymphoma cells in vitro and in vivo through calpain inhibition. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 3.4.22.52 Proteinuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33208557&form=6&db=m Inhibiting calpain 1 and 2 in cyclin G associated kinase-knockout mice mitigates podocyte injury. causal interaction,therapeutic application,unassigned 1,2,0 3.4.22.52 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17460283&form=6&db=m Inhibitory effects of retinoic acid receptor alpha stimulants on murine cataractogenesis through suppression of deregulated calpains. causal interaction,unassigned 2,0 3.4.22.52 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28469577&form=6&db=m Interference with Ca(2+)-Dependent Proteolysis Does Not Alter the Course of Muscle Wasting in Experimental Cancer Cachexia. causal interaction,therapeutic application,unassigned 3,2,0 3.4.22.52 Arthralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34006144&form=6&db=m Intracellular versus extracellular inhibition of calpain I causes differential effects on pain in a rat model of joint inflammation. ongoing research,unassigned 4,0 3.4.22.52 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34006144&form=6&db=m Intracellular versus extracellular inhibition of calpain I causes differential effects on pain in a rat model of joint inflammation. ongoing research,unassigned 4,0 3.4.22.52 Synovitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34006144&form=6&db=m Intracellular versus extracellular inhibition of calpain I causes differential effects on pain in a rat model of joint inflammation. ongoing research,unassigned 4,0 3.4.22.52 Spermatic Cord Torsion http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11327551&form=6&db=m Involvement of calpain for apoptosis in dysfunction of the unaffected testis in rats with experimental testicular torsion. causal interaction,ongoing research,therapeutic application,unassigned 4,2,2,0 3.4.22.52 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15809334&form=6&db=m Involvement of calpain in osteoclastic bone resorption. diagnostic usage,ongoing research,unassigned 3,4,0 3.4.22.52 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10372919&form=6&db=m Ischemia-induced modifications of protein components of rat brain postsynaptic densities. unassigned - 3.4.22.52 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27402795&form=6&db=m Isoform-specific function of calpains in cell adhesion disruption: studies in postlactational mammary gland and breast cancer. ongoing research,unassigned 4,0 3.4.22.52 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27402795&form=6&db=m Isoform-specific function of calpains in cell adhesion disruption: studies in postlactational mammary gland and breast cancer. ongoing research,unassigned 4,0 3.4.22.52 Protein Deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12119304&form=6&db=m Klotho protein deficiency leads to overactivation of mu-calpain. unassigned - 3.4.22.52 Fanconi Anemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20518497&form=6&db=m Knockdown of mu-calpain in Fanconi anemia, FA-A, cells by siRNA restores alphaII spectrin levels and corrects chromosomal instability and defective DNA interstrand cross-link repair. causal interaction,unassigned 4,0 3.4.22.52 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33473299&form=6&db=m Knockout of calpain-1 protects against high-fat diet-induced liver dysfunction in mouse through inhibiting oxidative stress and inflammation. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,2 3.4.22.52 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26966280&form=6&db=m Leukocyte Calpain Deficiency Reduces Angiotensin II-Induced Inflammation and Atherosclerosis But Not Abdominal Aortic Aneurysms in Mice. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 3.4.22.52 calpain-2 deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26966280&form=6&db=m Leukocyte Calpain Deficiency Reduces Angiotensin II-Induced Inflammation and Atherosclerosis But Not Abdominal Aortic Aneurysms in Mice. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 3.4.22.52 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32618099&form=6&db=m LIPH promotes metastasis by enriching stem-like cells in triple-negative breast cancer. ongoing research,unassigned 2,0 3.4.22.52 Muscular Dystrophies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32348180&form=6&db=m Loss of calpains-1 and -2 prevents repair of plasma membrane scrape injuries, but not small pores, and induces a severe muscular dystrophy. diagnostic usage,therapeutic application,unassigned 1,3,0 3.4.22.52 Neuromuscular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32348180&form=6&db=m Loss of calpains-1 and -2 prevents repair of plasma membrane scrape injuries, but not small pores, and induces a severe muscular dystrophy. diagnostic usage,therapeutic application,unassigned 1,3,0 3.4.22.52 Paraplegia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32348180&form=6&db=m Loss of calpains-1 and -2 prevents repair of plasma membrane scrape injuries, but not small pores, and induces a severe muscular dystrophy. diagnostic usage,therapeutic application,unassigned 1,3,0 3.4.22.52 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25539577&form=6&db=m Low calpain-9 is associated with adverse disease-specific survival following endocrine therapy in breast cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,3,0 3.4.22.52 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24333731&form=6&db=m LRH1 as a driving factor in pancreatic cancer growth. ongoing research,unassigned 2,0 3.4.22.52 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31258688&form=6&db=m Lycium barbarum polysaccharide attenuates cardiac hypertrophy, inhibits calpain-1 expression and inhibits NF-?B activation in streptozotocin-induced diabetic rats. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,2 3.4.22.52 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31258688&form=6&db=m Lycium barbarum polysaccharide attenuates cardiac hypertrophy, inhibits calpain-1 expression and inhibits NF-?B activation in streptozotocin-induced diabetic rats. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,2 3.4.22.52 Leishmaniasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21149457&form=6&db=m Mechanism of down-regulation of RNA polymerase III-transcribed non-coding RNA genes in macrophages by Leishmania. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 3.4.22.52 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34162146&form=6&db=m Melatonin-mediated MT2 attenuates colitis induced by dextran sodium sulfate via PI3K/AKT/Nrf2/SIRT1/ROR?/NF-?B signaling pathways. causal interaction,therapeutic application,unassigned 1,1,0 3.4.22.52 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30132537&form=6&db=m Microarray and pattern miner analysis of AXL and VIM gene networks in MDA?MB?231 cells. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 3.4.22.52 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32382656&form=6&db=m miR-124 Intensified Oxaliplatin-Based Chemotherapy by Targeting CAPN2 in Colorectal Cancer. therapeutic application,unassigned 2,0 3.4.22.52 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32382656&form=6&db=m miR-124 Intensified Oxaliplatin-Based Chemotherapy by Targeting CAPN2 in Colorectal Cancer. therapeutic application,unassigned 2,0 3.4.22.52 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32382656&form=6&db=m miR-124 Intensified Oxaliplatin-Based Chemotherapy by Targeting CAPN2 in Colorectal Cancer. therapeutic application,unassigned 2,0 3.4.22.52 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28100026&form=6&db=m miR-203 inhibits augmented proliferation and metastasis of hepatocellular carcinoma residual in the promoted regenerating liver. causal interaction,unassigned 3,0 3.4.22.52 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27994509&form=6&db=m MiR-99a and MiR-491 Regulate Cisplatin Resistance in Human Gastric Cancer Cells by Targeting CAPNS1. ongoing research,therapeutic application,unassigned 3,1,0 3.4.22.52 Ataxia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23741357&form=6&db=m Missense mutation in CAPN1 is associated with spinocerebellar ataxia in the Parson Russell Terrier dog breed. causal interaction,unassigned 4,0 3.4.22.52 Spinocerebellar Ataxias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23741357&form=6&db=m Missense mutation in CAPN1 is associated with spinocerebellar ataxia in the Parson Russell Terrier dog breed. causal interaction,unassigned 4,0 3.4.22.52 Diabetic Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26470784&form=6&db=m Mitochondrial Calpain-1 Disrupts ATP Synthase and Induces Superoxide Generation in Type 1 Diabetic Hearts: A Novel Mechanism Contributing to Diabetic Cardiomyopathy. causal interaction,ongoing research,unassigned 3,2,0 3.4.22.52 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16259951&form=6&db=m Mitochondrial localization of mu-calpain. ongoing research,unassigned 4,0 3.4.22.52 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19393648&form=6&db=m Mitochondrial mu-calpain is not involved in the processing of apoptosis-inducing factor. unassigned - 3.4.22.52 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10067969&form=6&db=m Modifications to rat lens major intrinsic protein in selenite-induced cataract. ongoing research,therapeutic application,unassigned 3,1,0 3.4.22.52 Meningioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11147878&form=6&db=m Molecular alterations in the neurofibromatosis type 2 gene and its protein rarely occurring in meningothelial meningiomas. diagnostic usage,unassigned 3,0 3.4.22.52 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8858942&form=6&db=m mu-calpain activation and calpain-mediated cytoskeletal proteolysis following traumatic brain injury. causal interaction,therapeutic application,unassigned 4,4,0 3.4.22.52 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8858942&form=6&db=m mu-calpain activation and calpain-mediated cytoskeletal proteolysis following traumatic brain injury. causal interaction,therapeutic application,unassigned 4,4,0 3.4.22.52 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12750552&form=6&db=m Mu-calpain activation in beta-lapachone-mediated apoptosis. causal interaction,therapeutic application,unassigned 1,1,0 3.4.22.52 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16574073&form=6&db=m mu-Calpain is involved in the regulation of TNF-alpha-induced matrix metalloproteinase-3 release in a rheumatoid synovial cell line. causal interaction,unassigned 3,0 3.4.22.52 Status Epilepticus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18395616&form=6&db=m Mu-calpain mediates hippocampal neuron death in rats after lithium-pilocarpine-induced status epilepticus. unassigned - 3.4.22.52 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19705411&form=6&db=m mu-Calpain regulates caspase-dependent and apoptosis inducing factor-mediated caspase-independent apoptotic pathways in cisplatin-induced apoptosis. ongoing research,unassigned 3,0 3.4.22.52 Amyotrophic Lateral Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31982778&form=6&db=m Mutation analysis of CAPN1 in Chinese populations with spastic paraplegia and related neurodegenerative diseases. causal interaction,unassigned 4,0 3.4.22.52 Ataxia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31982778&form=6&db=m Mutation analysis of CAPN1 in Chinese populations with spastic paraplegia and related neurodegenerative diseases. causal interaction,unassigned 4,0 3.4.22.52 Muscle Spasticity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31982778&form=6&db=m Mutation analysis of CAPN1 in Chinese populations with spastic paraplegia and related neurodegenerative diseases. causal interaction,unassigned 4,0 3.4.22.52 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31982778&form=6&db=m Mutation analysis of CAPN1 in Chinese populations with spastic paraplegia and related neurodegenerative diseases. causal interaction,unassigned 4,0 3.4.22.52 Paraplegia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31982778&form=6&db=m Mutation analysis of CAPN1 in Chinese populations with spastic paraplegia and related neurodegenerative diseases. causal interaction,unassigned 4,0 3.4.22.52 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31982778&form=6&db=m Mutation analysis of CAPN1 in Chinese populations with spastic paraplegia and related neurodegenerative diseases. causal interaction,unassigned 4,0 3.4.22.52 Spastic Paraplegia, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31982778&form=6&db=m Mutation analysis of CAPN1 in Chinese populations with spastic paraplegia and related neurodegenerative diseases. causal interaction,unassigned 4,0 3.4.22.52 Spinocerebellar Ataxias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31982778&form=6&db=m Mutation analysis of CAPN1 in Chinese populations with spastic paraplegia and related neurodegenerative diseases. causal interaction,unassigned 4,0 3.4.22.52 calpain-1 deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27153400&form=6&db=m Mutations in CAPN1 Cause Autosomal-Recessive Hereditary Spastic Paraplegia. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 3.4.22.52 Paraplegia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27153400&form=6&db=m Mutations in CAPN1 Cause Autosomal-Recessive Hereditary Spastic Paraplegia. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 3.4.22.52 Spastic Paraplegia, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27153400&form=6&db=m Mutations in CAPN1 Cause Autosomal-Recessive Hereditary Spastic Paraplegia. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 3.4.22.52 Spastic Paraplegia, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27259058&form=6&db=m Mutations in CAPN1 Cause Autosomal-Recessive Hereditary Spastic Paraplegia. causal interaction,unassigned 3,0 3.4.22.52 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18070881&form=6&db=m N terminus of calpain 1 is a mitochondrial targeting sequence. ongoing research,unassigned 1,0 3.4.22.52 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30206770&form=6&db=m Neuregulin-1? Plays a Neuroprotective Role by Inhibiting the Cdk5 Signaling Pathway after Cerebral Ischemia-Reperfusion Injury in Rats. causal interaction,therapeutic application,unassigned 4,1,0 3.4.22.52 Glaucoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18673213&form=6&db=m Neuroprotection in glaucoma using calpain-1 inhibitors: regional differences in calpain-1 activity in the trabecular meshwork, optic nerve and implications for therapeutics. causal interaction,therapeutic application,unassigned 3,4,0 3.4.22.52 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22925661&form=6&db=m Neuroprotective effect of 20(R)-ginsenoside Rg(3) against transient focal cerebral ischemia in rats. causal interaction,therapeutic application,unassigned 4,3,0 3.4.22.52 Infarction, Middle Cerebral Artery http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29249590&form=6&db=m Neuroprotective Effects of Oxytocin Hormone after an Experimental Stroke Model and the Possible Role of Calpain-1. ongoing research,therapeutic application,unassigned 4,3,0 3.4.22.52 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29249590&form=6&db=m Neuroprotective Effects of Oxytocin Hormone after an Experimental Stroke Model and the Possible Role of Calpain-1. ongoing research,therapeutic application,unassigned 4,3,0 3.4.22.52 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16802320&form=6&db=m Neurovascular and neuronal protection by E64d after focal cerebral ischemia in rats. ongoing research,therapeutic application,unassigned 4,4,0 3.4.22.52 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7663378&form=6&db=m Neutrophil chemotactic N-acetyl peptides from the calpain small subunit are also chemotactic for immunocytes. diagnostic usage,ongoing research,unassigned 3,4,0 3.4.22.52 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29507677&form=6&db=m New localization and function of calpain-2 in nucleoli of colorectal cancer cells in ribosomal biogenesis: effect of KRAS status. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0 3.4.22.52 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15365549&form=6&db=m NF-Kappa-B downregulation strategies in head and neck cancer treatment. ongoing research,therapeutic application,unassigned 2,3,0 3.4.22.52 Neoplasms, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15365549&form=6&db=m NF-Kappa-B downregulation strategies in head and neck cancer treatment. ongoing research,therapeutic application,unassigned 2,3,0 3.4.22.52 Essential Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11836545&form=6&db=m Normal erythrocyte calpain I activity on membrane proteins under near-physiological conditions in patients with essential hypertension. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,2,0 3.4.22.52 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11836545&form=6&db=m Normal erythrocyte calpain I activity on membrane proteins under near-physiological conditions in patients with essential hypertension. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,2,0 3.4.22.52 Ataxia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32860341&form=6&db=m Novel CAPN1 mutations extend the phenotypic heterogeneity in combined spastic paraplegia and ataxia. causal interaction,therapeutic application,unassigned 4,1,0 3.4.22.52 Cerebellar Ataxia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32860341&form=6&db=m Novel CAPN1 mutations extend the phenotypic heterogeneity in combined spastic paraplegia and ataxia. causal interaction,therapeutic application,unassigned 4,1,0 3.4.22.52 Paraplegia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32860341&form=6&db=m Novel CAPN1 mutations extend the phenotypic heterogeneity in combined spastic paraplegia and ataxia. causal interaction,therapeutic application,unassigned 4,1,0 3.4.22.52 Spastic Paraplegia, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32860341&form=6&db=m Novel CAPN1 mutations extend the phenotypic heterogeneity in combined spastic paraplegia and ataxia. causal interaction,therapeutic application,unassigned 4,1,0 3.4.22.52 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26484927&form=6&db=m Novel Selective Calpain 1 Inhibitors as Potential Therapeutics in Alzheimer's Disease. causal interaction,therapeutic application,unassigned 4,4,0 3.4.22.52 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16524385&form=6&db=m Oestrogen receptor subtype-specific repression of calpain expression and calpain enzymatic activity in neuronal cells - implications for neuroprotection against Ca-mediated excitotoxicity. ongoing research,therapeutic application,unassigned 3,1,0 3.4.22.52 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16524385&form=6&db=m Oestrogen receptor subtype-specific repression of calpain expression and calpain enzymatic activity in neuronal cells - implications for neuroprotection against Ca-mediated excitotoxicity. ongoing research,therapeutic application,unassigned 3,1,0 3.4.22.52 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29228653&form=6&db=m Overexpression of CAPN2 promotes cell metastasis and proliferation via AKT/mTOR signaling in renal cell carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,1,0 3.4.22.52 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29228653&form=6&db=m Overexpression of CAPN2 promotes cell metastasis and proliferation via AKT/mTOR signaling in renal cell carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,1,0 3.4.22.52 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29228653&form=6&db=m Overexpression of CAPN2 promotes cell metastasis and proliferation via AKT/mTOR signaling in renal cell carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,1,0 3.4.22.52 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29228653&form=6&db=m Overexpression of CAPN2 promotes cell metastasis and proliferation via AKT/mTOR signaling in renal cell carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,1,0 3.4.22.52 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33887737&form=6&db=m Overexpression of Capns1 Predicts Poor Prognosis and Correlates with Tumor Progression in Renal Cell Carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1 3.4.22.52 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33887737&form=6&db=m Overexpression of Capns1 Predicts Poor Prognosis and Correlates with Tumor Progression in Renal Cell Carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1 3.4.22.52 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33887737&form=6&db=m Overexpression of Capns1 Predicts Poor Prognosis and Correlates with Tumor Progression in Renal Cell Carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1 3.4.22.52 Status Epilepticus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19056471&form=6&db=m Participation of mu-calpain in status epilepticus-induced hippocampal injury. unassigned - 3.4.22.52 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24158126&form=6&db=m Perspective on rhabdomyolysis-induced acute kidney injury and new treatment options. causal interaction,ongoing research,unassigned 1,3,0 3.4.22.52 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9637408&form=6&db=m pH dependency of mu-calpain and m-calpain activity assayed by casein zymography following traumatic brain injury in the rat. diagnostic usage,ongoing research,unassigned 3,2,0 3.4.22.52 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33321157&form=6&db=m pH-sensitive multi-drug liposomes targeting folate receptor ? for efficient treatment of non-small cell lung cancer. causal interaction,unassigned 4,0 3.4.22.52 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30052328&form=6&db=m Pharmacokinetics, Safety, Tolerability, and Pharmacodynamics of Alicapistat, a Selective Inhibitor of Human Calpains 1 and 2 for the Treatment of Alzheimer Disease: An Overview of Phase 1 Studies. causal interaction,therapeutic application,unassigned 3,4,0 3.4.22.52 Anemia, Sickle Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23085996&form=6&db=m Pharmacological inhibition of calpain-1 prevents red cell dehydration and reduces Gardos channel activity in a mouse model of sickle cell disease. ongoing research,therapeutic application,unassigned 3,2,0 3.4.22.52 Dehydration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23085996&form=6&db=m Pharmacological inhibition of calpain-1 prevents red cell dehydration and reduces Gardos channel activity in a mouse model of sickle cell disease. ongoing research,therapeutic application,unassigned 3,2,0 3.4.22.52 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26431040&form=6&db=m Physiological Roles of Calpain 1 Associated to Multiprotein NMDA Receptor Complex. ongoing research,unassigned 3,0 3.4.22.52 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18071073&form=6&db=m Platelet sarcoplasmic endoplasmic reticulum Ca2+-ATPase and mu-calpain activity are altered in type 2 diabetes mellitus and restored by rosiglitazone. causal interaction,therapeutic application,unassigned 3,1,0 3.4.22.52 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18071073&form=6&db=m Platelet sarcoplasmic endoplasmic reticulum Ca2+-ATPase and mu-calpain activity are altered in type 2 diabetes mellitus and restored by rosiglitazone. causal interaction,therapeutic application,unassigned 3,1,0 3.4.22.52 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33258989&form=6&db=m Platelet-derived calpain cleaves the endothelial protease-activated receptor 1 to induce vascular inflammation in diabetes. causal interaction,ongoing research,unassigned 3,2,0 3.4.22.52 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10072294&form=6&db=m Postictal blockade of ischemic hippocampal neuronal death in primates using selective cathepsin inhibitors. diagnostic usage,unassigned 3,0 3.4.22.52 Ataxia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29152136&form=6&db=m Postnatal calpain inhibition elicits cerebellar cell death and motor dysfunction. diagnostic usage,therapeutic application,unassigned 3,2,0 3.4.22.52 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30390003&form=6&db=m Potassium usnate, a water-soluble usnic acid salt, shows enhanced bioavailability and inhibits invasion and metastasis in colorectal cancer. unassigned - 3.4.22.52 Spinal Cord Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10737623&form=6&db=m Pretreatment with calpain inhibitor CEP-4143 inhibits calpain I activation and cytoskeletal degradation, improves neurological function, and enhances axonal survival after traumatic spinal cord injury. causal interaction,therapeutic application,unassigned 1,4,0 3.4.22.52 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32951272&form=6&db=m Promotive effect of Talin-1 protein on gastric cancer progression through PTK2-PXN-VCL-E-Cadherin-CAPN2-MAPK1 signaling axis. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0 3.4.22.52 Malaria, Cerebral http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21914552&form=6&db=m Proteolytic breakdown of cytoskeleton induces neurodegeneration during pathology of murine cerebral malaria. ongoing research,unassigned 4,0 3.4.22.52 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29895528&form=6&db=m Proteomics study of serum exosomes from papillary thyroid cancer patients. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,1,0 3.4.22.52 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29895528&form=6&db=m Proteomics study of serum exosomes from papillary thyroid cancer patients. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,1,0 3.4.22.52 Spinal Cord Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9326288&form=6&db=m Rapid calpain I activation and cytoskeletal protein degradation following traumatic spinal cord injury: attenuation with riluzole pretreatment. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,3,0 3.4.22.52 Vascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30266074&form=6&db=m Redox Regulation of Calpains: Consequences on Vascular Function. causal interaction,unassigned 3,0 3.4.22.52 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32477605&form=6&db=m Relationship between the mRNA Expression Levels of Calpains 1/2 and Proteins Involved in Cytoskeleton Remodeling. causal interaction,diagnostic usage,unassigned 3,2,0 3.4.22.52 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20298691&form=6&db=m RNAi targeting micro-calpain increases neuron survival and preserves hippocampal function after global brain ischemia. causal interaction,ongoing research,therapeutic application,unassigned 1,4,2,0 3.4.22.52 Amyotrophic Lateral Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25151305&form=6&db=m Role of calpain-1 in the early phase of experimental ALS. unassigned - 3.4.22.52 Abortion, Habitual http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18336387&form=6&db=m Role of mu-Calpain in Human Decidua for Recurrent Miscarriage. ongoing research,unassigned 3,0 3.4.22.52 Myocardial Stunning http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9048660&form=6&db=m Role of troponin I proteolysis in the pathogenesis of stunned myocardium. causal interaction,therapeutic application,unassigned 1,2,0 3.4.22.52 Cardiotoxicity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32995293&form=6&db=m Rosuvastatin and simvastatin attenuate cisplatin-induced cardiotoxicity via disruption of endoplasmic reticulum stress-mediated apoptotic death in rats: targeting ER-Chaperone GRP78 and Calpain-1 pathways. therapeutic application,unassigned 1,0 3.4.22.52 Myocardial Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16981728&form=6&db=m Selective Deletion of the NH(2)-Terminal Variable Region of Cardiac Troponin T in Ischemia Reperfusion by Myofibril-Associated mu-Calpain Cleavage. therapeutic application,unassigned 3,0 3.4.22.52 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10428767&form=6&db=m Sepsis stimulates release of myofilaments in skeletal muscle by a calcium-dependent mechanism. causal interaction,unassigned 3,0 3.4.22.52 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28280729&form=6&db=m Silencing CAPN2 Expression Inhibited Castration-Resistant Prostate Cancer Cells Proliferation and Invasion via AKT/mTOR Signal Pathway. causal interaction,therapeutic application,unassigned 3,3,0 3.4.22.52 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30767945&form=6&db=m Simvastatin Improves Cardiac Hypertrophy in Diabetic Rats by Attenuation of Oxidative Stress and Inflammation Induced by Calpain-1-Mediated Activation of Nuclear Factor-?B (NF-?B). diagnostic usage,unassigned 3,0 3.4.22.52 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27414193&form=6&db=m STK33 potentiates the malignancy of hypopharyngeal squamous carcinoma: Possible relation to calcium. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,1 3.4.22.52 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9469158&form=6&db=m Subcellular localization and duration of mu-calpain and m-calpain activity after traumatic brain injury in the rat: a casein zymography study. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 3.4.22.52 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9469158&form=6&db=m Subcellular localization and duration of mu-calpain and m-calpain activity after traumatic brain injury in the rat: a casein zymography study. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 3.4.22.52 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17514421&form=6&db=m Synergetic Effects of Caspase 3 and mu-Calpain in XIAP-Breakdown upon Focal Cerebral Ischemia. therapeutic application,unassigned 2,0 3.4.22.52 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9371247&form=6&db=m Synthesis and biological activity of a series of potent fluoromethyl ketone inhibitors of recombinant human calpain I. therapeutic application,unassigned 1,0 3.4.22.52 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8110498&form=6&db=m Tamoxifen enhances the cytotoxic effects of the nitrosourea fotemustine. Results on human melanoma cell lines. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,2,0 3.4.22.52 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22367208&form=6&db=m Targeted gene inactivation of calpain-1 suppresses cortical degeneration due to traumatic brain injury and neuronal apoptosis induced by oxidative stress. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 3.4.22.52 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22367208&form=6&db=m Targeted gene inactivation of calpain-1 suppresses cortical degeneration due to traumatic brain injury and neuronal apoptosis induced by oxidative stress. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 3.4.22.52 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32968209&form=6&db=m Targeted inhibition of calpain in mitochondria alleviates oxidative stress-induced myocardial injury. causal interaction,unassigned 3,0 3.4.22.52 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32968209&form=6&db=m Targeted inhibition of calpain in mitochondria alleviates oxidative stress-induced myocardial injury. causal interaction,unassigned 3,0 3.4.22.52 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21911754&form=6&db=m Targeted inhibition of calpain reduces myocardial hypertrophy and fibrosis in mouse models of type 1 diabetes. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 3.4.22.52 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28789934&form=6&db=m Targeting calpains: A novel immunomodulatory approach for microbial infections. causal interaction,therapeutic application,unassigned 2,1,0 3.4.22.52 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32413000&form=6&db=m TGF-? Pathway Inhibition Protects the Diaphragm From Sepsis-Induced Wasting and Weakness in Rat. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,1,0 3.4.22.52 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32413000&form=6&db=m TGF-? Pathway Inhibition Protects the Diaphragm From Sepsis-Induced Wasting and Weakness in Rat. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,1,0 3.4.22.52 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31188263&form=6&db=m TGF-? Pathway Inhibition Protectsthe Diaphragm From Sepsis-Induced Wasting and Weakness in Rat. causal interaction,therapeutic application,unassigned 2,1,0 3.4.22.52 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28082186&form=6&db=m The Abnormal Architecture of Healed Diabetic Ulcers Is the Result of FAK Degradation by Calpain 1. causal interaction,unassigned 3,0 3.4.22.52 Ichthyosis, Lamellar http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10606846&form=6&db=m The calcium-activated neutral protease calpain I is present in normal foetal skin and is decreased in neonatal harlequin ichthyosis. diagnostic usage,ongoing research,unassigned 1,4,0 3.4.22.52 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11516996&form=6&db=m The calpain family and human disease. causal interaction,diagnostic usage,unassigned 4,1,0 3.4.22.52 Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11516996&form=6&db=m The calpain family and human disease. causal interaction,diagnostic usage,unassigned 4,1,0 3.4.22.52 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11516996&form=6&db=m The calpain family and human disease. causal interaction,diagnostic usage,unassigned 4,1,0 3.4.22.52 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27487486&form=6&db=m The calpain inhibitor calpeptin suppresses pancreatic cancer by disrupting cancer-stromal interactions in a mouse xenograft model. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,2,0 3.4.22.52 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27323818&form=6&db=m The calpain system is associated with survival of breast cancer patients with large but operable inflammatory and non-inflammatory tumours treated with neoadjuvant chemotherapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,2,1 3.4.22.52 Inflammatory Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27323818&form=6&db=m The calpain system is associated with survival of breast cancer patients with large but operable inflammatory and non-inflammatory tumours treated with neoadjuvant chemotherapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,2,1 3.4.22.52 Dyskinesias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26119916&form=6&db=m The combination of lithium and l-Dopa/Carbidopa reduces MPTP-induced abnormal involuntary movements (AIMs) via calpain-1 inhibition in a mouse model: Relevance for Parkinson?s disease therapy. therapeutic application,unassigned 4,0 3.4.22.52 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17157313&form=6&db=m The crystal structures of human calpains 1 and 9 imply diverse mechanisms of action and auto-inhibition. causal interaction,ongoing research,unassigned 1,3,0 3.4.22.52 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17157313&form=6&db=m The crystal structures of human calpains 1 and 9 imply diverse mechanisms of action and auto-inhibition. causal interaction,ongoing research,unassigned 1,3,0 3.4.22.52 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32825941&form=6&db=m The expression of calpain-1 and androgen receptor in breast cancer and their correlation with clinicopathological characteristics: An immunohistochemical retrospective study. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 3.4.22.52 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32825941&form=6&db=m The expression of calpain-1 and androgen receptor in breast cancer and their correlation with clinicopathological characteristics: An immunohistochemical retrospective study. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 3.4.22.52 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32825941&form=6&db=m The expression of calpain-1 and androgen receptor in breast cancer and their correlation with clinicopathological characteristics: An immunohistochemical retrospective study. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 3.4.22.52 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16612007&form=6&db=m The expression of genes related to adipocyte differentiation in pigs. unassigned - 3.4.22.52 Urinary Incontinence http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19756344&form=6&db=m The role of calpain-calpastatin system in the development of stress urinary incontinence. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,1,0 3.4.22.52 Aneurysm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26582478&form=6&db=m The role of extracellular and intracellular proteolytic systems in aneurysms of the ascending aorta. causal interaction,diagnostic usage,unassigned 3,2,0 3.4.22.52 Aortic Aneurysm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26582478&form=6&db=m The role of extracellular and intracellular proteolytic systems in aneurysms of the ascending aorta. causal interaction,diagnostic usage,unassigned 3,2,0 3.4.22.52 Meningioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10606247&form=6&db=m Tight association of loss of merlin expression with loss of heterozygosity at chromosome 22q in sporadic meningiomas. causal interaction,ongoing research,therapeutic application,unassigned 3,3,3,0 3.4.22.52 Neurilemmoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10606247&form=6&db=m Tight association of loss of merlin expression with loss of heterozygosity at chromosome 22q in sporadic meningiomas. causal interaction,ongoing research,therapeutic application,unassigned 3,3,3,0 3.4.22.52 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19062176&form=6&db=m Transfection with liver-type glutaminase cDNA alters gene expression and reduces survival, migration and proliferation of T98G glioma cells. diagnostic usage,ongoing research,unassigned 2,3,0 3.4.22.52 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16150694&form=6&db=m Truncation and activation of calcineurin A by calpain I in Alzheimer disease brain. unassigned - 3.4.22.52 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25918155&form=6&db=m Truncation and Activation of Dual Specificity Tyrosine Phosphorylation-regulated Kinase 1A by Calpain I: A MOLECULAR MECHANISM LINKED TO TAU PATHOLOGY IN ALZHEIMER DISEASE. causal interaction,unassigned 1,0 3.4.22.52 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25641096&form=6&db=m Truncation and activation of GSK-3? by calpain I: a molecular mechanism links to tau hyperphosphorylation in Alzheimer's disease. causal interaction,unassigned 3,0 3.4.22.52 Ataxia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31023339&form=6&db=m Two novel homozygous mutations of CAPN1 in Chinese patients with hereditary spastic paraplegia and literatures review. causal interaction,diagnostic usage,ongoing research,unassigned 2,2,1,0 3.4.22.52 Paraplegia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31023339&form=6&db=m Two novel homozygous mutations of CAPN1 in Chinese patients with hereditary spastic paraplegia and literatures review. causal interaction,diagnostic usage,ongoing research,unassigned 2,2,1,0 3.4.22.52 Spastic Paraplegia, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31023339&form=6&db=m Two novel homozygous mutations of CAPN1 in Chinese patients with hereditary spastic paraplegia and literatures review. causal interaction,diagnostic usage,ongoing research,unassigned 2,2,1,0 3.4.22.52 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21585285&form=6&db=m Type V collagen-induced upregulation of capn2 (large subunit of m-calpain) gene expression and DNA fragmentation in 8701-BC breast cancer cells. unassigned - 3.4.22.52 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31830479&form=6&db=m Verapamil decreases calpain-1 and matrix metalloproteinase-2 activities and improves hypertension-induced hypertrophic cardiac remodeling in rats. causal interaction,ongoing research,therapeutic application,unassigned 2,4,1,0 3.4.22.52 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31830479&form=6&db=m Verapamil decreases calpain-1 and matrix metalloproteinase-2 activities and improves hypertension-induced hypertrophic cardiac remodeling in rats. causal interaction,ongoing research,therapeutic application,unassigned 2,4,1,0 3.4.22.52 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31830479&form=6&db=m Verapamil decreases calpain-1 and matrix metalloproteinase-2 activities and improves hypertension-induced hypertrophic cardiac remodeling in rats. causal interaction,ongoing research,therapeutic application,unassigned 2,4,1,0 3.4.22.52 Hypertension, Renovascular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31830479&form=6&db=m Verapamil decreases calpain-1 and matrix metalloproteinase-2 activities and improves hypertension-induced hypertrophic cardiac remodeling in rats. causal interaction,ongoing research,therapeutic application,unassigned 2,4,1,0 3.4.22.52 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8464868&form=6&db=m Widespread activation of calcium-activated neutral proteinase (calpain) in the brain in Alzheimer disease: a potential molecular basis for neuronal degeneration. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,2,1 3.4.22.52 Huntington Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8464868&form=6&db=m Widespread activation of calcium-activated neutral proteinase (calpain) in the brain in Alzheimer disease: a potential molecular basis for neuronal degeneration. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,2,1 3.4.22.52 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19177143&form=6&db=m Wnt5A Activates the Calpain-Mediated Cleavage of Filamin A. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 3.4.22.52 Leukemia, Myeloid, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21961413&form=6&db=m [Beta-carotene regulates the expression of proapoptotic BAX and CAPN2 in HL-60, U-937 and TF-1 - human acute myeloid leukemia cell lines; microarray, RQ-PCR and Western Blot analysis]. ongoing research,unassigned 3,0 3.4.22.52 Atrial Fibrillation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17445406&form=6&db=m [Calpain I inhibition prevents pacing-induced structural remodeling for atrial fibrillation in canine] causal interaction,therapeutic application,unassigned 1,3,0 3.4.22.52 Atrial Fibrillation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16776917&form=6&db=m [Calpain-I, calpastatin, caspase-3 and apoptosis in the human left atrium in rheumatic atrial fibrillation] diagnostic usage,ongoing research,therapeutic application,unassigned 4,4,1,0 3.4.22.52 Rheumatic Heart Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16776917&form=6&db=m [Calpain-I, calpastatin, caspase-3 and apoptosis in the human left atrium in rheumatic atrial fibrillation] diagnostic usage,ongoing research,therapeutic application,unassigned 4,4,1,0 3.4.22.52 Atrial Fibrillation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18001554&form=6&db=m [Effect of calpain 1 on structural remodeling and contractile dysfunction in atrial fibrillation: experiment with dogs] causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,3,1 3.4.22.52 Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21781600&form=6&db=m [Effect of valsartan and carnitine on cardiomyocyte Calpain-1 and Bcl-xl expressions of dogs with chronic alcohol intake-induced cardiomyopathy]. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,4,0 3.4.22.52 Arsenic Poisoning http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24641850&form=6&db=m [Effects of arsenic poisoning on neuronal cell apoptosis and mRNA and protein expression of calpain 1, calpain 2, and cdk5/p25]. diagnostic usage,ongoing research,unassigned 1,3,0 3.4.22.52 Atrial Fibrillation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18756973&form=6&db=m [Influence of oxidative stress on atrial myocardium pathohistological and ultrastructural changes in atrial fibrillation: experiment with dogs] ongoing research,unassigned 4,0 3.4.22.52 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25924429&form=6&db=m [Protective effects of levetiracetam and simvastatin on pilocarpine-induced epilepsy in rat models]. causal interaction,therapeutic application,unassigned 4,1,0 3.4.22.52 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25924429&form=6&db=m [Protective effects of levetiracetam and simvastatin on pilocarpine-induced epilepsy in rat models]. causal interaction,therapeutic application,unassigned 4,1,0 3.4.22.52 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22943648&form=6&db=m [Role of valsartan on myocardial Calpain I, calcineurin and Ca/calmodulin-dependent protein kinase II? expression of renovascular hypertensive rats]. ongoing research,therapeutic application,unassigned 4,1,0 3.4.22.52 Myalgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17681928&form=6&db=m [Study on correlation between single nucleotide polymorphism of CAPN1 gene and muscle tenderness and carcass traits in chicken] ongoing research,unassigned 3,0 3.4.22.52 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7742602&form=6&db=m [Tamoxifen increases cytotoxic effects of fotemustine. Experimental results on cell lines of human melanoma] diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,2,0 3.4.22.52 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12882707&form=6&db=m [The changes of gene expression in multiple myeloma treated with thalidomide] diagnostic usage,therapeutic application,unassigned 3,1,0