3.4.22.B50	ubiquitin-7-amido-4-trifluoromethylcoumarin + H2O	the enzyme catalyzes proteolytic processing of the viral polyprotein and also shows significant in vitro deubiquitinating and de-ISGylating activities. The enzyme binds ubiquitin, the ubiquitin core makes mostly hydrophilic interactions with the enzyme, while the Leu-Arg-Gly-Gly C-terminus of ubiquitin is located in the catalytic cleft of the enzyme. The ubiquitin core binds to the palm, thumb and fingers domains of the enzyme, while its final four C-terminal residues bind into a narrow channel by a network of hydrogen bonds and reach towards the active site	Severe acute respiratory syndrome-related coronavirus	ubiquitin + 7-amino-4-trifluoromethylcoumarin	-	?	432450	
3.4.22.B50	VAKQGAGFKRTY + H2O	-	Human coronavirus NL63	VAKQGA + GFKRTY	-	?	418118	
3.4.22.B50	Z-KKAG-7-amido-4-methylcoumarin + H2O	the catalytic efficiency toward Z-KKAG-7-amido-4-methylcoumarin is 5times higher than that for Z-LRGG-7-amido-4-methylcoumarin	infectious bronchitis virus	Z-KKAG + 7-amino-4-methylcoumarin	-	?	432499	
3.4.22.B50	Z-LRGG-7-amido-4-methylcoumarin + H2O	-	infectious bronchitis virus	Z-LRGG + 7-amino-4-methylcoumarin	-	?	432502