3.4.22.B50	ISLKGGKIVSTC	12 mer oligopeptide containing Gly2740-Lys2741, 29% cleavage	Alphacoronavirus	?	-	?	384934	
3.4.22.B50	ISLKGGKIVSTC	12 mer oligopeptide containing Gly2740-Lys2741, 29% cleavage	Alphacoronavirus SARS-CoV	?	-	?	384934	
3.4.22.B50	MHV substrate	-	Alphacoronavirus	?	-	?	385188	
3.4.22.B50	additional information	Cys1715 is a catalytic residue of PLP2	Murine coronavirus	?	-	?	89	
3.4.22.B50	additional information	no in vitro cleavage of the ORF 1a polyprotein in cis or in trans can be detected with PLP-2 expressed either as a polypeptide, including flanking viral sequences, or as an MBP fusion protein	Murine coronavirus	?	-	?	89	
3.4.22.B50	additional information	the enzyme is one of three distinct viral proteases (PLP1, PLP2 and 3CLpro) involved in processing of the replicase polyprotein	Murine coronavirus	?	-	?	89	
3.4.22.B50	additional information	SARS-CoV PLP2 does not cleave HCoV.229E and IBV substrates	Alphacoronavirus	?	-	?	89	
3.4.22.B50	additional information	proteolytic processing of the human coronavirus 229E. PL2pro is able to cleave the nsp1-nsp2 cleavage site. PL2pro plays a universal and essential proteolytic role that appears to be assisted by the PL1pro paralog at specific sites	Human coronavirus 229E	?	-	?	89	
3.4.22.B50	additional information	the core domain of PLP2 has in vivo deubiquitinase and DeISGylation activity	Human coronavirus NL63	?	-	?	89	
3.4.22.B50	additional information	the enzyme cannot cleave Z-KAGG-7-amido-4-methylcoumarin	infectious bronchitis virus	?	-	?	89