1.1.1.1 alcohol dehydrogenase brain - 285604 1.1.1.10 L-xylulose reductase brain low expression level 656049 1.1.1.101 acylglycerone-phosphate reductase brain - 285684 1.1.1.102 3-dehydrosphinganine reductase brain - 285699 1.1.1.103 L-threonine 3-dehydrogenase brain - 285720, 655125 1.1.1.105 all-trans-retinol dehydrogenase (NAD+) brain - 697796 1.1.1.105 all-trans-retinol dehydrogenase (NAD+) brain strong mRNA expression 692959 1.1.1.112 indanol dehydrogenase brain - 285758 1.1.1.14 L-iditol 2-dehydrogenase brain - 285879, 655289 1.1.1.141 15-hydroxyprostaglandin dehydrogenase (NAD+) brain - 285912, 285930, 699476 1.1.1.145 3beta-hydroxy-DELTA5-steroid dehydrogenase brain - 740247, 740503 1.1.1.145 3beta-hydroxy-DELTA5-steroid dehydrogenase brain significant seasonal and sexual dimorphic changes in the levels of transcript abundance in the whole brain and its regions. In whole brain, level is the highest in post-spawning phase and lowest in spawning phase in males. In females, there is a progressive increase through resting phase to pre-spawning phase, a decline in the spawning phase and increase in the post-spawning phase 740503 1.1.1.145 3beta-hydroxy-DELTA5-steroid dehydrogenase brain twenty-four hours after bilateral contusion of the medial prefrontal cortex, similar levels of 3beta-hydroxysteroid dehydrogenase mRNA expression are observed in males and pseudopregnant females in the non-injured group, with a significant decrease in the 3beta-hydroxysteroid dehydrogenase mRNA expression in the contusion site within the frontal cortex in both males and pseudopregnant females. In all other regions analyzed, 3beta-hydroxysteroid dehydrogenase mRNA expression is not affected by traumatic brain injury and there is no difference between males and pseudopregnant females 681643 1.1.1.146 11beta-hydroxysteroid dehydrogenase brain - 654196, 688527, 711800, 740146, 740917, 760680, 760682, 760868, 762011 1.1.1.146 11beta-hydroxysteroid dehydrogenase brain low level of expression, low acitivity 693886 1.1.1.146 11beta-hydroxysteroid dehydrogenase brain weak expression 693886 1.1.1.149 20alpha-hydroxysteroid dehydrogenase brain - 763094 1.1.1.149 20alpha-hydroxysteroid dehydrogenase brain 20alpha-HSD mRNA highly expressed 285997 1.1.1.149 20alpha-hydroxysteroid dehydrogenase brain analysis of 3alpha-HSOR mRNA distribution in the mouse brain by in situ hybridization has shown that this enzyme is co-localized with 5alpha-R type 1 in neurons of the cerebral cortex, hippocampus, olfactory bulb, amygdala and thalamus. And 3alpha-HSOR immunoreactivity is largely distributed in both white and gray matters 763094 1.1.1.149 20alpha-hydroxysteroid dehydrogenase brain low expression rate of AKR1C23 669908 1.1.1.153 sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming) brain - -, 286013, 286020, 286023, 286024, 286033, 655138, 684899, 761589 1.1.1.153 sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming) brain in all parts of the brain -, 286023 1.1.1.153 sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming) brain sepiapterin reductase expression is increased in Parkinsons disease brain tissue 685875 1.1.1.162 erythrulose reductase brain - 286091 1.1.1.172 2-oxoadipate reductase brain - 286113 1.1.1.178 3-hydroxy-2-methylbutyryl-CoA dehydrogenase brain expressed in different regions 673530 1.1.1.178 3-hydroxy-2-methylbutyryl-CoA dehydrogenase brain levels of SCHAD/HADII are significantly reduced in the ventral midbrain of a Parkinson’s disease mouse model 673530 1.1.1.184 carbonyl reductase (NADPH) brain - 347749, 347751, 347754, 667427, 697262 1.1.1.184 carbonyl reductase (NADPH) brain strong expression of isozyme CHCR1, weaker expression of isozyme CHCR2, no expression of isozyme CHCR3 655213 1.1.1.188 prostaglandin-F synthase brain - 654851, 661605 1.1.1.188 prostaglandin-F synthase brain enzyme is expressed preferentially in the white matter bundles of the entire central nervous system of adult mice with less marked expression inneuronal cell bodies. The enzyme co-localizes with myelin basic protein in myelin sheaths but not in axons 707934 1.1.1.188 prostaglandin-F synthase brain high activity 687797 1.1.1.188 prostaglandin-F synthase brain highest activity 687797 1.1.1.188 prostaglandin-F synthase brain low expression level 760437 1.1.1.189 prostaglandin-E2 9-reductase brain - 654851, 657211 1.1.1.19 glucuronate reductase brain - 286147 1.1.1.196 15-hydroxyprostaglandin-D dehydrogenase (NADP+) brain - 347824, 347825, 347826 1.1.1.197 15-hydroxyprostaglandin dehydrogenase (NADP+) brain - 347830, 347835 1.1.1.2 alcohol dehydrogenase (NADP+) brain - -, 286164, 286166, 286168, 286172, 286174, 286175, 286176, 286177, 286178, 286181, 286182, 286183, 286184, 286186, 286190, 286214, 286215, 286217, 288554 1.1.1.2 alcohol dehydrogenase (NADP+) brain midbrain, hypothalamus and pons 286164 1.1.1.2 alcohol dehydrogenase (NADP+) brain pons, medulla and midbrain 286213 1.1.1.209 3(or 17)alpha-hydroxysteroid dehydrogenase brain - 389547 1.1.1.21 aldose reductase brain - 286239, 286240, 286241, 286242, 286246, 738593, 761409 1.1.1.21 aldose reductase brain ox 286251, 286252 1.1.1.211 long-chain-3-hydroxyacyl-CoA dehydrogenase brain - -, 740102, 740438 1.1.1.211 long-chain-3-hydroxyacyl-CoA dehydrogenase brain adult and fetal 670476 1.1.1.216 farnesol dehydrogenase (NADP+) brain and midgut, of adult female, highest levels of mRNA 713402 1.1.1.220 6-pyruvoyltetrahydropterin 2'-reductase brain - 286308 1.1.1.220 6-pyruvoyltetrahydropterin 2'-reductase brain highest concentration in striatum and midbrain 286309 1.1.1.225 chlordecone reductase brain - 286316 1.1.1.27 L-lactate dehydrogenase brain - 670394, 689715, 712102 1.1.1.27 L-lactate dehydrogenase brain contains a skeletal muscle type and heart type mixed heterotetrameric enzyme, H2M2 740001 1.1.1.270 3beta-hydroxysteroid 3-dehydrogenase brain - 286475 1.1.1.270 3beta-hydroxysteroid 3-dehydrogenase brain adult, juvenile, and developing 673822 1.1.1.28 D-lactate dehydrogenase brain - 286488 1.1.1.284 S-(hydroxymethyl)glutathione dehydrogenase brain - 287888, 697214 1.1.1.284 S-(hydroxymethyl)glutathione dehydrogenase brain GSNOR is the sole alcohol dehydrogenase isozyme in vertebrate brains 726053 1.1.1.30 3-hydroxybutyrate dehydrogenase brain - 286518, 286520, 655126, 689351 1.1.1.300 NADP-retinol dehydrogenase brain - 654687, 656098, 761195, 762061 1.1.1.300 NADP-retinol dehydrogenase brain low mRNA expression 690876 1.1.1.31 3-hydroxyisobutyrate dehydrogenase brain - 688515 1.1.1.315 11-cis-retinol dehydrogenase brain 8% mRNA expression of Rdh5 compared to liver 690797 1.1.1.315 11-cis-retinol dehydrogenase brain low activity 692700 1.1.1.345 D-2-hydroxyacid dehydrogenase (NAD+) brain - 287843 1.1.1.35 3-hydroxyacyl-CoA dehydrogenase brain - 286269, 286589, 286591, 673340, 723558 1.1.1.357 3alpha-hydroxysteroid 3-dehydrogenase brain - 725333, 762009, 763094, 763517 1.1.1.357 3alpha-hydroxysteroid 3-dehydrogenase brain analysis of 3alpha-HSOR mRNA distribution in the mouse brain by in situ hybridization has shown that this enzyme is co-localized with 5alpha-R type 1 in neurons of the cerebral cortex, hippocampus, olfactory bulb, amygdala and thalamus. And 3alpha-HSOR immunoreactivity is largely distributed in both white and gray matters 763094 1.1.1.36 acetoacetyl-CoA reductase brain fetal, very low expression of isozyme AKR1B15.2 740743 1.1.1.40 malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) brain - 286714, 286734 1.1.1.41 isocitrate dehydrogenase (NAD+) brain - 286757, 286758, 741458 1.1.1.42 isocitrate dehydrogenase (NADP+) brain - 286792, 656588 1.1.1.44 phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating) brain low activity in female and male rats, constant at age 2 months to age 9 months 655737 1.1.1.45 L-gulonate 3-dehydrogenase brain - 286909 1.1.1.49 glucose-6-phosphate dehydrogenase (NADP+) brain - 287014, 287017, 675105 1.1.1.49 glucose-6-phosphate dehydrogenase (NADP+) brain negative correlation between locomotion of rats in the open field and activity of G-6-PDH in the sensorimotor cortex, especially in efferent layer V neurons and neurons of the caudate nucleus and nucleus accumbens, which attests to different capacity of the brain in Wistar rats with high and low open-field locomotion to regeneration of phosphopyridine nucleotides (NADP(+)) and production of pentoses via the pentose phosphate shunt. No correlation between enzyme activity in the hippocampus and locomotion 697060 1.1.1.50 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) brain - 389525, 656651 1.1.1.50 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) brain distribution in brain regions of cytosolic and particulate 5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase activity 389557, 389559 1.1.1.50 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) brain from male rats -, 741098 1.1.1.50 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) brain NADH-linked 5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase activity is decreased by 40-50% in lactating rats 389559 1.1.1.51 3(or 17)beta-hydroxysteroid dehydrogenase brain - 699146, 761195 1.1.1.51 3(or 17)beta-hydroxysteroid dehydrogenase brain in female hamsters 740637 1.1.1.51 3(or 17)beta-hydroxysteroid dehydrogenase brain isozyme 17beta-HSD8 675476 1.1.1.53 3alpha(or 20beta)-hydroxysteroid dehydrogenase brain - 668684, 688455, 698084 1.1.1.53 3alpha(or 20beta)-hydroxysteroid dehydrogenase brain weak expression of subunit A, moderate expression of subunit B 762606 1.1.1.55 lactaldehyde reductase (NADPH) brain - 389564 1.1.1.62 17beta-estradiol 17-dehydrogenase brain - 656654, 688956, 740849 1.1.1.62 17beta-estradiol 17-dehydrogenase brain fetal, very low expression of isozyme AKR1B15.2 740743 1.1.1.62 17beta-estradiol 17-dehydrogenase brain HSD17B4 mRNA and activity are detectable in the early developing and adult brain 711609 1.1.1.62 17beta-estradiol 17-dehydrogenase brain HSD17B4 mRNA is expressed more in the song regions of males compared to females throughout development. Females have significantly higher levels of HSD17B4 mRNA in auditory (caudomedial nidopallium) and visual (hyperpalliumapicale)regions than does males at day 25 740245 1.1.1.64 testosterone 17beta-dehydrogenase (NADP+) brain low activity in both sexes 669905 1.1.1.71 alcohol dehydrogenase [NAD(P)+] brain - 655563 1.1.1.77 lactaldehyde reductase brain - 287308 1.1.1.78 methylglyoxal reductase (NADH) brain - 207968 1.1.1.8 glycerol-3-phosphate dehydrogenase (NAD+) brain - -, 287336, 287345 1.1.1.81 hydroxypyruvate reductase brain - 287380 1.1.1.87 homoisocitrate dehydrogenase brain mRNA level of isoform Rdh10 declines during development, with strong and lasting expression in the meninges and choroid plexuses. Expression is also present in the striatum 687988 1.1.1.88 hydroxymethylglutaryl-CoA reductase brain results show that docosahexaenoic acid ethyl ester enhances brain HMG-CoA reductase activity in aged mice 688564 1.1.1.95 phosphoglycerate dehydrogenase brain - 287380, 287526, 287528 1.1.1.95 phosphoglycerate dehydrogenase brain enzyme expression in the subventricular neural progenitor cells, but not in differentiated neurons. The subventricular neural progenitor cells also show a decline in Phgdh expression in type B and C cells in the aged brain 700463 1.1.1.95 phosphoglycerate dehydrogenase brain Phgdh is constitutively expressed in the brain 700437