1.6.3.1 NAD(P)H oxidase (H2O2-forming) glia primary culture of mixed glia. Incubation of cultures in the presence of fibrillar amyloid beta1-42 induces the assembly and the activation of NADPH oxidase, and triggers the production of superoxide anion-derived reactive oxygen species. Pretreatment of microglia with melatonin dose-dependently prevents the activation of NADPH oxidase and decreases the production of reactive oxygen species. Melatonin inhibits the phosphorylation of the p47phox subunit of NADPH oxidase via a PI3K/Akt-dependent signalling pathway, blocks the translocation of p47phox and p67phox subunit to the membrane, down-regulates the binding of p47phox to gp91phox, and impairs the assembly of NADPH oxidase 688627 2.7.11.24 mitogen-activated protein kinase glia mixed glial cultures 702065 3.1.4.11 phosphoinositide phospholipase C glia - 715713 3.1.4.3 phospholipase C glia primary -, 716352 3.1.4.37 2',3'-cyclic-nucleotide 3'-phosphodiesterase glia olfactory bulb ensheathing glia in explant cultures 653364 3.3.2.10 soluble epoxide hydrolase glia restricted primarily to oligodendrocytes in the white matter 708573 4.2.1.1 carbonic anhydrase glia - 33547 5.1.1.18 serine racemase glia - 706532 5.3.4.1 protein disulfide-isomerase glia - 3079 6.3.2.41 N-acetylaspartylglutamate synthase glia cerebellar glia cell 728179