1.1.1.87 homoisocitrate dehydrogenase corpus striatum mRNA level of isoform Rdh10 declines during development, with strong and lasting expression in the meninges and choroid plexuses. Expression is also present in the striatum 687988 1.11.1.6 catalase corpus striatum the catalase activity in striatum is significantly decreased in the lesioned group as compared to sham group and pretreatment with Withania somnifera reverses its activity significantly and dose dependently in the lesioned goup pretretaed with 100 mg/kg 200 mg/ml or 300 mg/kg body weight extracts of Withania somnifera orally as compared to lesioned group 673928 1.13.11.5 homogentisate 1,2-dioxygenase corpus striatum - 743037 1.13.11.52 indoleamine 2,3-dioxygenase corpus striatum - 700466 1.14.11.67 [histone H3]-trimethyl-L-lysine4 demethylase corpus striatum - -, 713122 1.14.13.39 nitric-oxide synthase (NADPH) corpus striatum - 686293 1.14.14.18 heme oxygenase (biliverdin-producing) corpus striatum - 688506 1.14.16.2 tyrosine 3-monooxygenase corpus striatum - 676753, 685885, 688545, 689215, 690099, 695399, 697761, 700417 1.14.16.2 tyrosine 3-monooxygenase corpus striatum dorsal 688523 1.14.16.2 tyrosine 3-monooxygenase corpus striatum dorsal striatum 700464 1.14.16.4 tryptophan 5-monooxygenase corpus striatum - 689232 1.3.5.1 succinate dehydrogenase corpus striatum - 686054 1.3.5.1 succinate dehydrogenase corpus striatum 15-20% inhibition of complex II activity in striatum and hippocampus by methylmalonic acid at low concentrations of sucinate in the medium, but not in the peripheral tissue. the inhibitory property only occurs after exposing brain homogenates for at least 10 min with the acid, suggesting that this inhibition is mediated by indirect mechanisms 674053 1.4.3.3 D-amino-acid oxidase corpus striatum - 688608 1.4.3.4 monoamine oxidase corpus striatum - 705454 1.4.3.4 monoamine oxidase corpus striatum unilateral injection of 6-hydroxydopamine produces no change in striatal MAO-A or MAO-B activity, but following the double lesion, MAO-B activity increases by 37.5% with no change in MAO-A activity 688486 1.6.99.1 NADPH dehydrogenase corpus striatum - 673464 1.8.5.1 glutathione dehydrogenase (ascorbate) corpus striatum myelin sheet 394026 2.3.1.23 1-acylglycerophosphocholine O-acyltransferase corpus striatum - 755989 2.3.1.6 choline O-acetyltransferase corpus striatum ChAT activity is higher in Ts65Dn mice at both 19 and 24 months of age compared to normogenic animals 689183 2.3.2.5 glutaminyl-peptide cyclotransferase corpus striatum - 759702 2.3.3.1 citrate (Si)-synthase corpus striatum - 720443, 720554 2.4.3.8 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase corpus striatum highest expression 760219 2.6.1.64 glutamine-phenylpyruvate transaminase corpus striatum - -, 759850 2.7.1.138 ceramide kinase corpus striatum - -, 760851 2.7.11.1 non-specific serine/threonine protein kinase corpus striatum MAST3 shows selective expression in striatum and cortex as determined by in situ hybridization 691552 2.7.11.11 cAMP-dependent protein kinase corpus striatum - 710589 2.7.11.12 cGMP-dependent protein kinase corpus striatum - 661442 2.7.11.13 protein kinase C corpus striatum - 662331, 662492 2.7.11.22 cyclin-dependent kinase corpus striatum - 693747 2.7.3.2 creatine kinase corpus striatum - 685344, 762017 2.7.3.2 creatine kinase corpus striatum creatine kinase activity is not altered if rats are submitted to renal ischemia -, 689220 2.7.7.86 cyclic GMP-AMP synthase corpus striatum - 762288 3.1.1.34 lipoprotein lipase corpus striatum - 716346 3.1.1.7 acetylcholinesterase corpus striatum - 693989, 694391 3.1.1.8 cholinesterase corpus striatum - 730237 3.1.2.2 palmitoyl-CoA hydrolase corpus striatum - 646167 3.1.2.20 acyl-CoA hydrolase corpus striatum - 646167 3.1.3.41 4-nitrophenylphosphatase corpus striatum - 664474 3.1.4.12 sphingomyelin phosphodiesterase corpus striatum in hippocampus the enzyme activity is significantly higher than in striatum and cortex. Age-related decreases in the hippocampal and striatal cytosolic N-Sase activities are accompanied by increases in the membrane N-Sase activities -, 666446 3.1.4.17 3',5'-cyclic-nucleotide phosphodiesterase corpus striatum - 694373 3.1.4.17 3',5'-cyclic-nucleotide phosphodiesterase corpus striatum dorsal striatum 693825 3.1.4.17 3',5'-cyclic-nucleotide phosphodiesterase corpus striatum PDE10A is highly expressed in the medium spiny neurons of the striatum 693820 3.1.4.53 3',5'-cyclic-AMP phosphodiesterase corpus striatum - 693748, 694373 3.1.4.53 3',5'-cyclic-AMP phosphodiesterase corpus striatum age-related increases in isoform PDE8A3 protein expression are confirmed in hippocampus of old versus young rodents 729558 3.1.4.54 N-acetylphosphatidylethanolamine-hydrolysing phospholipase D corpus striatum - 707099 3.3.2.10 soluble epoxide hydrolase corpus striatum - 708573 3.3.2.9 microsomal epoxide hydrolase corpus striatum - -, 710118 3.4.11.3 cystinyl aminopeptidase corpus striatum - 669925 3.4.11.7 glutamyl aminopeptidase corpus striatum - 665836 3.4.17.10 carboxypeptidase E corpus striatum - 81293 3.4.17.22 metallocarboxypeptidase D corpus striatum - 28967 3.4.19.12 ubiquitinyl hydrolase 1 corpus striatum - 710422 3.4.21.26 prolyl oligopeptidase corpus striatum - 694399, 707107 3.4.21.68 t-Plasminogen activator corpus striatum - 707932 3.4.21.94 proprotein convertase 2 corpus striatum - 709603 3.4.22.52 calpain-1 corpus striatum - 700426 3.4.22.59 caspase-6 corpus striatum - -, 698177 3.4.22.61 caspase-8 corpus striatum - 699692 3.4.23.46 memapsin 2 corpus striatum BACE1 is significantly and time-dependently increased in the ipsilateral striatum 700416 3.4.23.46 memapsin 2 corpus striatum changes in caspase-3, amyloid beta and BACE1 levels are detected in rat striatum on different days after middle cerebral artery occlusion using immunostaining. The positive labeled cells of activated caspase-3, amyloid beta, and BACE1 are significantly and time-dependently increased in the ipsilateral striatum 700416 3.4.24.11 neprilysin corpus striatum - 81639 3.4.24.11 neprilysin corpus striatum distribution of neprilysin is high in the striatum, globus pallidus, and substantia nigra, but very low in the cerebral cortex 701381 3.4.24.16 neurolysin corpus striatum - 734522 3.4.24.35 gelatinase B corpus striatum - 709634, 709650 3.5.3.15 protein-arginine deiminase corpus striatum - 695453 3.6.1.7 acylphosphatase corpus striatum - 758508 3.6.1.7 acylphosphatase corpus striatum human primary striatal neuronal precursor cell, HSP. Relative RNA expression level of ACYP in HSP cells is determined by real-time reverse transcription PCR. No expression of isozyme ACYP1 758508 3.6.1.9 nucleotide diphosphatase corpus striatum - 698337 4.1.1.15 glutamate decarboxylase corpus striatum - 700470 4.1.1.22 histidine decarboxylase corpus striatum high levels of HDC protein are also found in the striatum 716351 4.1.1.28 aromatic-L-amino-acid decarboxylase corpus striatum - 4222, 4227, 664473, 691888, 715979 4.1.1.28 aromatic-L-amino-acid decarboxylase corpus striatum clozapine modulates AAAD activity in striatum and enhances exogenous L-DOPA decarboxylation in intact mice and mice lesioned with1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Kinetic analysis of AAAD at 1 h showed an increase in the apparent Vmax for both the substrate L-DOPA and the cofactor pyridoxal-5'-phosphate with no changes for Km. Dopamine D4 and 5-HT2A and 5-HT1A antagonists also increase AAAD activity in striatum 666154 4.6.1.1 adenylate cyclase corpus striatum - 694363, 707801 4.6.1.1 adenylate cyclase corpus striatum isozyme AC5 694405 5.1.1.18 serine racemase corpus striatum - 728034 5.1.1.18 serine racemase corpus striatum expression in gamma-aminobutyrate, i.e. GABAergic medium-spine neuron 693369 5.1.1.18 serine racemase corpus striatum gamma-aminobutyric acid-ergic medium spiny neurons 726664 5.1.1.18 serine racemase corpus striatum increase of enzyme expression after birth 660638 5.6.2.1 DNA topoisomerase corpus striatum - 662523 6.3.1.2 glutamine synthetase corpus striatum anterior corpus striatum 705272 6.3.4.5 argininosuccinate synthase corpus striatum in a rat ischemia model the striatum is examined at 24, 72 and 144 h after reperfusion and compared with rats in normal conditions. At 24 h after reperfusion, the number of the nitric oxide synthase-positive neurons and the percentage of those co-expressing argininosuccinate synthetase and argininsuccinate lyase and nitric oxide synthase are significantly increased in the animals with a longer survival 673486