1.1.1.149 20alpha-hydroxysteroid dehydrogenase cerebral cortex - 763094 1.1.1.153 sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming) cerebral cortex - 761589 1.1.1.153 sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming) cerebral cortex pyramidal neurons 655138 1.1.1.178 3-hydroxy-2-methylbutyryl-CoA dehydrogenase cerebral cortex - 673530 1.1.1.188 prostaglandin-F synthase cerebral cortex - 389457 1.1.1.21 aldose reductase cerebral cortex - -, 739113 1.1.1.211 long-chain-3-hydroxyacyl-CoA dehydrogenase cerebral cortex - -, 740102 1.1.1.278 3beta-hydroxy-5alpha-steroid dehydrogenase cerebral cortex activity below detection limit of 0.1 fmol/mg protein/min 639089 1.1.1.315 11-cis-retinol dehydrogenase cerebral cortex 5% mRNA expression of Rdh5 compared to liver 690797 1.1.1.357 3alpha-hydroxysteroid 3-dehydrogenase cerebral cortex - 763094 1.1.1.62 17beta-estradiol 17-dehydrogenase cerebral cortex moderate expression 685803 1.11.1.12 phospholipid-hydroperoxide glutathione peroxidase cerebral cortex - -, 765297 1.11.1.9 glutathione peroxidase cerebral cortex - 686868 1.13.11.34 arachidonate 5-lipoxygenase cerebral cortex - -, 689167 1.14.11.67 [histone H3]-trimethyl-L-lysine4 demethylase cerebral cortex - -, 713122 1.14.13.39 nitric-oxide synthase (NADPH) cerebral cortex - 440224, 686293, 700433 1.14.14.18 heme oxygenase (biliverdin-producing) cerebral cortex - 686269 1.14.14.25 cholesterol 24-hydroxylase cerebral cortex - 735877 1.14.14.25 cholesterol 24-hydroxylase cerebral cortex pyramidal neurons 687987 1.14.15.4 steroid 11beta-monooxygenase cerebral cortex - 688009 1.14.16.2 tyrosine 3-monooxygenase cerebral cortex - 695603 1.14.16.2 tyrosine 3-monooxygenase cerebral cortex developing, intereurons, the majority of cortical tyrosine hydroxylase cells at all ages contains phosphorylated tyrosine hydroxylase 685887 1.14.16.5 alkylglycerol monooxygenase cerebral cortex - 688220 1.14.17.1 dopamine beta-monooxygenase cerebral cortex - 727633 1.14.99.1 prostaglandin-endoperoxide synthase cerebral cortex - 686417 1.14.99.1 prostaglandin-endoperoxide synthase cerebral cortex PGHS-2 has highest abundance in hippocampus and cerebral cortex 698086 1.14.99.1 prostaglandin-endoperoxide synthase cerebral cortex PGSHS-1 has highest abundance in hippocampus and cerebral cortex 698086 1.16.3.1 ferroxidase cerebral cortex - 689209 1.17.1.4 xanthine dehydrogenase cerebral cortex - 644557, 644558 1.17.1.4 xanthine dehydrogenase cerebral cortex high rate of dehydrogenase activity 644557, 644558 1.2.1.105 2-oxoglutarate dehydrogenase system cerebral cortex - 673870, 762740 1.2.1.12 glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) cerebral cortex - 656594 1.2.1.25 branched-chain alpha-keto acid dehydrogenase system cerebral cortex - 763513 1.2.3.1 aldehyde oxidase cerebral cortex - 390422 1.2.4.4 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) cerebral cortex - 725082 1.21.99.3 thyroxine 5-deiodinase cerebral cortex isozyme type III 644796, 644798 1.3.1.24 biliverdin reductase cerebral cortex - 725769 1.3.5.1 succinate dehydrogenase cerebral cortex - 686054 1.3.5.2 dihydroorotate dehydrogenase (quinone) cerebral cortex high enzyme level 713150 1.3.99.5 3-oxo-5alpha-steroid 4-dehydrogenase (acceptor) cerebral cortex prefrontal, expression of isozymes 5alpha-R1 and 5alpha-R2 655526 1.4.1.3 glutamate dehydrogenase [NAD(P)+] cerebral cortex - 762783 1.4.1.3 glutamate dehydrogenase [NAD(P)+] cerebral cortex high expression in astrocytes, low expression in neurons 712431 1.4.3.1 D-aspartate oxidase cerebral cortex - 743140 1.4.3.1 D-aspartate oxidase cerebral cortex relatively high enzyme expression just after birth, the content gradually decreases thereafter 711719 1.4.3.13 protein-lysine 6-oxidase cerebral cortex LOX on the surface of pyramidal cells in the grey matter, LOXL in the nuclei of cortex cells and in the cytosol of capillary endothelial cells 659751 1.4.3.3 D-amino-acid oxidase cerebral cortex - 699164, 723921, 742603 1.4.3.4 monoamine oxidase cerebral cortex environmentally relevant concentrations of Hg may influence the activities of ChE and MAO in the cerebral cortex 687025 1.4.3.5 pyridoxal 5'-phosphate synthase cerebral cortex 25.9% of the activity in liver 655483 1.6.1.2 NAD(P)+ transhydrogenase (Re/Si-specific) cerebral cortex - 658473 1.6.3.1 NAD(P)H oxidase (H2O2-forming) cerebral cortex cortical culture 689225 1.6.99.1 NADPH dehydrogenase cerebral cortex - 392796 1.6.99.1 NADPH dehydrogenase cerebral cortex distribution of NADPH-diaphorase activity in different human cortical areas, remarkable laminar and interareal differences across areas 672837 2.1.1.202 multisite-specific tRNA:(cytosine-C5)-methyltransferase cerebral cortex reduction of upper-layer neurons in the Nsun2 -/- cortex, mouse brain cortex at E18.5 showing the location of the indicated markers 758477 2.1.1.5 betaine-homocysteine S-methyltransferase cerebral cortex BHMT expression is observed in the amygdala of basal ganglia and the cerebral cortex where BHMT levels are clearly elevated during torpor 735112 2.1.1.6 catechol O-methyltransferase cerebral cortex membrane-bound COMT activities in the cerebral cortex are significantly reduced in high-salt loaded Dahl salt-sensitive rats compared with normal-salt loaded Dahl salt-sensitive rats 685455 2.2.1.1 transketolase cerebral cortex thiamine-deficinet diet reduces transketolase activity in both cortex and hippocampus, without significantly affecting the activities of pyruvate dehydrogenase, alpha-ketoglutamate dehydrogenase, and glucose 6-phosphate dehydrogenase 699663 2.3.1.105 alkylglycerophosphate 2-O-acetyltransferase cerebral cortex - 486104, 486105 2.3.1.23 1-acylglycerophosphocholine O-acyltransferase cerebral cortex anterior and posterior 755989 2.3.1.50 serine C-palmitoyltransferase cerebral cortex - 487177 2.3.1.6 choline O-acetyltransferase cerebral cortex - 736678 2.3.1.61 dihydrolipoyllysine-residue succinyltransferase cerebral cortex - 487343 2.3.1.67 1-alkylglycerophosphocholine O-acetyltransferase cerebral cortex - 487384, 487393 2.3.1.7 carnitine O-acetyltransferase cerebral cortex strong activity 720292 2.3.2.13 protein-glutamine gamma-glutamyltransferase cerebral cortex - -, 758981 2.3.2.27 RING-type E3 ubiquitin transferase cerebral cortex - 690750 2.3.2.5 glutaminyl-peptide cyclotransferase cerebral cortex - 758904 2.3.3.1 citrate (Si)-synthase cerebral cortex - 702966 2.4.1.174 glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase cerebral cortex - 638345 2.4.1.175 glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase cerebral cortex - 638345, 659262 2.4.1.206 lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase cerebral cortex fetal 638232, 638235 2.4.1.206 lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase cerebral cortex not adult 638235 2.4.1.214 glycoprotein 3-alpha-L-fucosyltransferase cerebral cortex - 661837 2.4.1.38 beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase cerebral cortex - 687078 2.4.1.41 polypeptide N-acetylgalactosaminyltransferase cerebral cortex - 658240 2.4.1.41 polypeptide N-acetylgalactosaminyltransferase cerebral cortex enzyme form pp-GalNAc-T15 658739 2.4.3.1 beta-galactoside alpha-(2,6)-sialyltransferase cerebral cortex - 637272 2.4.3.8 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase cerebral cortex - 639661, 723273, 759644, 760219 2.5.1.16 spermidine synthase cerebral cortex highest levels of expression in nucleus accumbens, taenia tecta, cerebellar cortex, cerebral cortical layer I, hippocampus, hypothalamus, mesencephalic raphe nuclei, central and lateral amygdala, and the circumventricular organs. Distinct presence in mossy fiber terminals of cerebellar cortex 688510 2.6.1.19 4-aminobutyrate-2-oxoglutarate transaminase cerebral cortex - 738349 2.6.1.42 branched-chain-amino-acid transaminase cerebral cortex - 673846 2.6.1.64 glutamine-phenylpyruvate transaminase cerebral cortex - -, 759850 2.7.1.1 hexokinase cerebral cortex - 723652 2.7.1.1 hexokinase cerebral cortex the contribution of glucokinase to total glucose-phosphorylating activity is of 15.3% in the cerebral cortex 705268 2.7.1.107 diacylglycerol kinase (ATP) cerebral cortex - 640358, 640386 2.7.1.149 1-phosphatidylinositol-5-phosphate 4-kinase cerebral cortex isoform PI5P4Kbeta is expressed in neuronal populations, especially hippocampus and cortex 759554 2.7.1.20 adenosine kinase cerebral cortex - 676193 2.7.1.40 pyruvate kinase cerebral cortex - 661404, 661406 2.7.1.68 1-phosphatidylinositol-4-phosphate 5-kinase cerebral cortex - 738165 2.7.11.1 non-specific serine/threonine protein kinase cerebral cortex expression of CK1epsilon-3 662955 2.7.11.1 non-specific serine/threonine protein kinase cerebral cortex MAST3 shows selective expression in striatum and cortex as determined by in situ hybridization 691552 2.7.11.12 cGMP-dependent protein kinase cerebral cortex predominant expression of isozyme cGKIbeta 662962 2.7.11.13 protein kinase C cerebral cortex - 725768 2.7.11.15 beta-adrenergic-receptor kinase cerebral cortex - 490911, 640698, 640709, 645000, 645003, 645005 2.7.11.15 beta-adrenergic-receptor kinase cerebral cortex brain: highest beta-ARK mRNA concentrations in cerebral cortex and cerebellum 490985 2.7.11.15 beta-adrenergic-receptor kinase cerebral cortex highest beta-ARK activity 645001 2.7.11.17 Ca2+/calmodulin-dependent protein kinase cerebral cortex - 694396, 694403, 705904, 761014 2.7.11.17 Ca2+/calmodulin-dependent protein kinase cerebral cortex cerebral cortical neuronal nucleus 694382 2.7.11.17 Ca2+/calmodulin-dependent protein kinase cerebral cortex isozymes CaMKIdelta and CaMKIalpha 676188 2.7.11.2 [pyruvate dehydrogenase (acetyl-transferring)] kinase cerebral cortex - 642132 2.7.11.22 cyclin-dependent kinase cerebral cortex - 662124, 662688, 664179, 666467, 695204 2.7.11.24 mitogen-activated protein kinase cerebral cortex - 697804, 703574 2.7.11.26 tau-protein kinase cerebral cortex - 662124, 760847 2.7.11.26 tau-protein kinase cerebral cortex cold-water stress-induced tau phosphorylation pattern 661724 2.7.11.26 tau-protein kinase cerebral cortex high expression 760847 2.7.11.31 [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase cerebral cortex - 760259 2.7.12.2 mitogen-activated protein kinase kinase cerebral cortex high expression level of MKK4 682214 2.7.12.2 mitogen-activated protein kinase kinase cerebral cortex highest levels of expression 682214 2.7.3.2 creatine kinase cerebral cortex - -, 705501, 705502, 739050 2.7.3.2 creatine kinase cerebral cortex in cerebral cortex creatine kinase activity is inhibited 6 and 12 h after renal ischemia. Only N-acetylcysteine or N-acetylcysteine plus deferoxamine are able to prevent the inhibition on the enzyme -, 689220 2.7.6.2 thiamine diphosphokinase cerebral cortex - 762503 2.7.8.11 CDP-diacylglycerol-inositol 3-phosphatidyltransferase cerebral cortex - 645316 2.7.9.3 selenide, water dikinase cerebral cortex - 762075 2.8.2.17 chondroitin 6-sulfotransferase cerebral cortex - 738897 2.8.2.23 [heparan sulfate]-glucosamine 3-sulfotransferase 1 cerebral cortex - 761164 2.8.2.23 [heparan sulfate]-glucosamine 3-sulfotransferase 1 cerebral cortex high expression level 761164 2.8.2.29 [heparan sulfate]-glucosamine 3-sulfotransferase 2 cerebral cortex high expression level 761164 2.8.2.5 chondroitin 4-sulfotransferase cerebral cortex - 695144 3.1.1.2 arylesterase cerebral cortex - 35206 3.1.1.23 acylglycerol lipase cerebral cortex - 650849, 653676 3.1.1.34 lipoprotein lipase cerebral cortex - 716346 3.1.1.4 phospholipase A2 cerebral cortex - 653367 3.1.1.4 phospholipase A2 cerebral cortex distribution of sPLa2-IIe, sPLA2-V, and sPLA2-X is mainly neuronal with highest abundance in cerebral cortex and hippocampus. Enzymes are differentially induced by kainic acid 666137 3.1.1.7 acetylcholinesterase cerebral cortex - 653365, 679180, 682110, 682902, 694391 3.1.1.8 cholinesterase cerebral cortex - 730237 3.1.2.2 palmitoyl-CoA hydrolase cerebral cortex - 646125, 646126, 646167 3.1.2.2 palmitoyl-CoA hydrolase cerebral cortex brain-specific isozyme 653187 3.1.2.20 acyl-CoA hydrolase cerebral cortex - 646125, 646126, 646167 3.1.3.16 protein-serine/threonine phosphatase cerebral cortex - 655140, 682117 3.1.3.41 4-nitrophenylphosphatase cerebral cortex - 682284 3.1.3.43 [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase cerebral cortex high expression 730476 3.1.3.48 protein-tyrosine-phosphatase cerebral cortex - -, 750705 3.1.3.5 5'-nucleotidase cerebral cortex - 679085, 682113, 692192 3.1.3.5 5'-nucleotidase cerebral cortex synaptosome 707925 3.1.3.56 inositol-polyphosphate 5-phosphatase cerebral cortex - 646382 3.1.3.9 glucose-6-phosphatase cerebral cortex - 134945 3.1.4.11 phosphoinositide phospholipase C cerebral cortex - 653348, 667504 3.1.4.11 phosphoinositide phospholipase C cerebral cortex expression of PLC delta2 649088 3.1.4.11 phosphoinositide phospholipase C cerebral cortex PLC-beta1 is highly expressed in the cerebral cortex and hippocampus 691473 3.1.4.11 phosphoinositide phospholipase C cerebral cortex PLCeta2 is restricted to brain. PLCeta2 gradually increases during brain development. PLCeta2 is not detected in embryos. At 1 week after birth PLCeta2 is barely detected and expression is first observed at weeks after birth 669369 3.1.4.17 3',5'-cyclic-nucleotide phosphodiesterase cerebral cortex external layer of 670448 3.1.4.3 phospholipase C cerebral cortex synaptosomes 666222 3.1.4.35 3',5'-cyclic-GMP phosphodiesterase cerebral cortex - 691558 3.1.4.4 phospholipase D cerebral cortex PLD2 expression is observed in the marginal zone from the earliest stage and then declines and completely disappears by embryonic day 20 666455 3.1.4.4 phospholipase D cerebral cortex synaptosomes 666222 3.1.4.46 glycerophosphodiester phosphodiesterase cerebral cortex - 679873 3.1.4.53 3',5'-cyclic-AMP phosphodiesterase cerebral cortex - 678086 3.1.4.54 N-acetylphosphatidylethanolamine-hydrolysing phospholipase D cerebral cortex - 707099 3.1.6.1 arylsulfatase (type I) cerebral cortex activity increases gradually during development 135532 3.1.6.1 arylsulfatase (type I) cerebral cortex no significant changes in enzyme level upon feeding ethanol-containing Lieber-DeCarli liquid diet 677433 3.1.6.8 cerebroside-sulfatase cerebral cortex - 677433 3.2.1.114 mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase cerebral cortex - 731972 3.2.1.207 mannosyl-oligosaccharide alpha-1,3-glucosidase cerebral cortex - 714910 3.2.1.207 mannosyl-oligosaccharide alpha-1,3-glucosidase cerebral cortex high expression level 745592 3.2.1.207 mannosyl-oligosaccharide alpha-1,3-glucosidase cerebral cortex higher expression -, 732369 3.2.1.28 alpha,alpha-trehalase cerebral cortex strong trehalase activity 750882 3.2.1.52 beta-N-acetylhexosaminidase cerebral cortex in affected cats with GM2 gangliosidosis, hexosaminidase beta-subunit mRNA levels are approximately 1.5times higher than normal, while beta-subunit protein levels are substantially reduced 700234 3.3.2.7 hepoxilin-epoxide hydrolase cerebral cortex - 647025 3.4.11.1 leucyl aminopeptidase cerebral cortex - 95178, 95227 3.4.11.14 cytosol alanyl aminopeptidase cerebral cortex - 682118 3.4.11.3 cystinyl aminopeptidase cerebral cortex - 669637 3.4.11.4 tripeptide aminopeptidase cerebral cortex - 35936 3.4.11.6 aminopeptidase B cerebral cortex - 35972, 682114 3.4.14.10 tripeptidyl-peptidase II cerebral cortex - 647148, 664475, 665981 3.4.14.9 tripeptidyl-peptidase I cerebral cortex - 752408 3.4.16.2 lysosomal Pro-Xaa carboxypeptidase cerebral cortex greatest level of signals are detected in the cerebral cortex with very strong labeling in the cingulate and piriform cortex. Other areas of the cortex show moderate signal intensity 731564 3.4.17.1 carboxypeptidase A cerebral cortex - 667459, 668122 3.4.17.15 carboxypeptidase A2 cerebral cortex - 667459 3.4.17.21 Glutamate carboxypeptidase II cerebral cortex cortical cells dissociated in cell culture 656609 3.4.17.22 metallocarboxypeptidase D cerebral cortex - 28967 3.4.17.23 angiotensin-converting enzyme 2 cerebral cortex - 679707 3.4.17.23 angiotensin-converting enzyme 2 cerebral cortex about 10% of the ACE2 gene expression in kidney cortex 668896 3.4.18.1 cathepsin X cerebral cortex - 683448 3.4.18.1 cathepsin X cerebral cortex of healthy individuals and Alzheimer patients 683448 3.4.19.12 ubiquitinyl hydrolase 1 cerebral cortex - 666444 3.4.19.12 ubiquitinyl hydrolase 1 cerebral cortex down-regulation of UCHL-1 mRNA and protein in dementia with Lewy bodies, either in pure forms not associated with Alzheimer disease, and in common forms, with accompanying Alzheimer disease changes, but not in Parkinson disease. UCHL-3 expression reduced in Parkinson disease and dementia with Lewy bodies 666444 3.4.21.108 HtrA2 peptidase cerebral cortex - 697749 3.4.21.109 matriptase cerebral cortex skin 698819 3.4.21.122 transmembrane protease serine 2 cerebral cortex immunoreactive cells are found in 3 days old but not in 1-month-old male rats 753658 3.4.21.26 prolyl oligopeptidase cerebral cortex - 683344 3.4.21.26 prolyl oligopeptidase cerebral cortex specific expression of POP in glutamatergic pyramidal neurons of the cerebral cortex, particularly in the primary motir and somatosensory cortices 683708 3.4.21.34 plasma kallikrein cerebral cortex prekallikrein expression 653115 3.4.21.61 Kexin cerebral cortex mild expression of PC1 and moderate expression of PC2. PC1 and PC2 in cerebral cortex colocalizes in pyramidal and non-pyramidal neurons with carboxypeptidase-E and somatostatin 683932 3.4.21.68 t-Plasminogen activator cerebral cortex - -, 718064, 732063 3.4.21.93 Proprotein convertase 1 cerebral cortex - 669904 3.4.21.93 Proprotein convertase 1 cerebral cortex colocalization with somatostatin, carboxypeptidase-E and PC2 in pyramidal and non-pyramidal neurons. Colocalization with carboxypeptidase-E confined to pyramidal neurons of deeper layer. PC1 exhibits 26% colocalization with somatostatin and 34% with carboxypeptidase-E 683932 3.4.21.94 proprotein convertase 2 cerebral cortex colocalization with somatostatin, carboxypeptidase-E and PC1 in pyramidal and non-pyramidal neurons. PC2 exhibits 30% colocalization with somatostatin and 44% with carboxypeptidase-E 683932 3.4.21.94 proprotein convertase 2 cerebral cortex high PC2 protein content at early ischeic reperfusion hour, which decreases with reperfusion time 709250 3.4.21.B42 hippostasin cerebral cortex expression revealed by immunohistochemistry 667873 3.4.22.1 cathepsin B cerebral cortex - 36638 3.4.22.27 cathepsin S cerebral cortex - 697041 3.4.22.49 separase cerebral cortex highly expressed in human fetal cerebral cortex compared with adult 681037 3.4.22.52 calpain-1 cerebral cortex - 643998, 680913 3.4.22.56 caspase-3 cerebral cortex - 699679 3.4.22.61 caspase-8 cerebral cortex ipsilateral side 697809 3.4.22.62 caspase-9 cerebral cortex mitochondrial fraction of cerebral tissue, hypoxia-treated, classified into a normoxic group and a hypoxic group 700460 3.4.22.62 caspase-9 cerebral cortex of newborn piglet 666462 3.4.22.62 caspase-9 cerebral cortex of newborn piglets 666456 3.4.22.B72 SENP3 peptidase cerebral cortex - -, 731627 3.4.22.B72 SENP3 peptidase cerebral cortex dynamic changes in SENP3 expression in the cerebral cortex and in its cellular localization in traumatic brain injury compared to normal, overview -, 731628 3.4.23.45 memapsin 1 cerebral cortex - 638899, 638903 3.4.23.45 memapsin 1 cerebral cortex samples from frontal cortex of both Alzheimer's disease-affected individuals and age-matched controls. Samples show substantial total amounts of BACE2 protein and enzymatic activity. BACE2 activity does not change significantly in the brain of patients with Alzheimer's disease, and is not related to amyloid beta-peptide concentration 712811 3.4.23.46 memapsin 2 cerebral cortex - 678539 3.4.23.46 memapsin 2 cerebral cortex samples from frontal cortex of both Alzheimer's disease-affected individuals and age-matched controls. BACE1 activity shows a significant positive correlation with the amount of extractable amyloid beta-peptide, and BACE1 protein and activity are significantly increased in cases of alzheimer's disease 712811 3.4.24.11 neprilysin cerebral cortex low level of neprilysin. Amyloid-beta deposition appears in the cerebral cortex and the hippocampus 701381 3.4.24.56 insulysin cerebral cortex after the development of first amyloid beta plaques in brain of transgenic mice with alzheimer's disease-like neuropathology, cortical mRNAand protein levels of IDE are significantly up-regulated in the transgenic mice compared to their non-transgenic littermates. Up-regulation of IDE mRNA-levels occurrs in parallel with increased amyloid beta40 and amyloid beta42 production. A significant positive correlation is observed between protein levels of IDE and full-length amyloid precursor protein in the cerebral cortex 700455 3.4.24.56 insulysin cerebral cortex in Alzheimer's disease patients the protein level of insulin-degrading enzyme is decreased compared to control. However, mRNA of insulin-degrading enzyme is higher in cortex of Alzheimer's disease patients 753340 3.4.24.56 insulysin cerebral cortex isolated brain microvessels, in patients with Alzheimer’s disease with cerebral amyloid angiopathy enzyme protein level is up to 44% increased, but enzyme activity is significantly reduced 667412 3.4.24.71 endothelin-converting enzyme 1 cerebral cortex ECE-1 expression in Alzheimer's disease brain shows no significant difference compared with age-matched controls 720290 3.4.24.B10 ADAM12 endopeptidase cerebral cortex fetal 670683 3.4.25.1 proteasome endopeptidase complex cerebral cortex - 688760 3.4.25.1 proteasome endopeptidase complex cerebral cortex from fetal ICR mice 711082 3.5.1.2 glutaminase cerebral cortex isozymes LGA and KGA 670391 3.5.3.11 agmatinase cerebral cortex agmatinase is localised pre- and postsynaptically, to dendritic spines, spine and non-spine terminals, and dendritic profiles. In dendritic spines, labelling displayed a tendency towards the postsynaptic density 718561 3.5.3.15 protein-arginine deiminase cerebral cortex - 695453 3.5.3.15 protein-arginine deiminase cerebral cortex in neuronal cells of the cerebral cortex 712824 3.5.4.37 double-stranded RNA adenine deaminase cerebral cortex spatiotemporal expression patterns for ADAR1 and ADAR2 in mouse forebrain. ADAR1 and ADAR2 are broadly distributed in most regions of the mouse forebrain, including the cerebral cortex, hippocampus, and diencephalon. High expression levels are maintained into adulthood. ADAR1 and ADAR2 are expressed in neurons but not astrocytes. ADAR1 mRNA has its lowest expression in the choroid plexus, cortex and hippocampus, while ADAR2 mRNA is least expressed in the cortex and hippocampus, with increased expression in the thalamus 719335 3.5.4.4 adenosine deaminase cerebral cortex - 695973, 711695 3.6.1.13 ADP-ribose diphosphatase cerebral cortex - 209946, 655991 3.6.1.28 thiamine-triphosphatase cerebral cortex - 668963 3.6.1.5 apyrase cerebral cortex - 757465 3.6.1.5 apyrase cerebral cortex increase in enzymic activity from birth to day 30, decrease afterwards, highest enzymic activity at day 30, highest affinity for enzyme at day 365, relative abundance of enzyme is highest at day 15 of ontogeny 668983 3.6.1.9 nucleotide diphosphatase cerebral cortex - 698337 3.6.5.2 small monomeric GTPase cerebral cortex of E17 mice -, 755959 4.1.1.15 glutamate decarboxylase cerebral cortex - -, 697807 4.1.1.19 arginine decarboxylase cerebral cortex presence of both arginine decarboxylase and arginase in principal neurons and putative interneurons 728614 4.1.1.22 histidine decarboxylase cerebral cortex - 716351 4.1.2.13 fructose-bisphosphate aldolase cerebral cortex - 651759 4.1.2.13 fructose-bisphosphate aldolase cerebral cortex isoenzyme III, IV, and V 4948 4.1.3.4 hydroxymethylglutaryl-CoA lyase cerebral cortex - 693782 4.3.2.1 argininosuccinate lyase cerebral cortex - 708319 4.3.2.9 gamma-glutamylcyclotransferase cerebral cortex weak expression 720332 4.4.1.5 lactoylglutathione lyase cerebral cortex - 682102 4.6.1.1 adenylate cyclase cerebral cortex - 691561 4.6.1.1 adenylate cyclase cerebral cortex ACIII localizes to cilia in adults, throughout the cortex, including the subiculum, as well as the retrosplenial granular, visual, motor, and orbital cortices -, 681092 4.6.1.2 guanylate cyclase cerebral cortex all neocortical areas with high expression of all subunits, expression of the three subunits in all cortical layers, alpha1 subunit enriched in layer VI 681090 4.6.1.2 guanylate cyclase cerebral cortex beta1 subunit mRNA widely distributed through all cortical areas and cell layers with higher intensity in layer V, alpha2 mRNA homogeneously distributed through all cortical layers and alpha1 expression higher in layers II–III and V 681090 5.1.1.13 aspartate racemase cerebral cortex - 706558, 728034 5.1.1.18 serine racemase cerebral cortex - -, 706540, 726664, 728034 5.1.1.18 serine racemase cerebral cortex glial culture from 663264 5.1.1.18 serine racemase cerebral cortex pyramidal neuron of cerebral cortex and hippocampal CA1 region, predominant localization 693369 5.6.1.1 microtubule-severing ATPase cerebral cortex - 675537, 699690 5.6.1.2 dynein ATPase cerebral cortex - 669959 5.6.2.1 DNA topoisomerase cerebral cortex neuron 3800 6.1.1.18 glutamine-tRNA ligase cerebral cortex - 743985 6.1.1.2 tryptophan-tRNA ligase cerebral cortex about 0.2% of total soluble protein 306 6.2.1.16 acetoacetate-CoA ligase cerebral cortex in cerebral cortex expression of AACS mRNA is restricetd to neuronal cells 661256 6.2.1.4 succinate-CoA ligase (GDP-forming) cerebral cortex - 745246 6.3.1.2 glutamine synthetase cerebral cortex - 692128 6.3.2.24 tyrosine-arginine ligase cerebral cortex - -, 745971 6.3.2.41 N-acetylaspartylglutamate synthase cerebral cortex - 728179 7.1.1.2 NADH:ubiquinone reductase (H+-translocating) cerebral cortex - 692231 7.1.1.9 cytochrome-c oxidase cerebral cortex - 686054 7.1.1.9 cytochrome-c oxidase cerebral cortex frontal cortex and posterior cortex 695205 7.1.1.9 cytochrome-c oxidase cerebral cortex regular alternation of areas with high and low levels of activity of the respiratory enzyme CO in layers III, IV, and VI of field 17 and in layers IV and VII of field 18 of the cerebral cortex 694377 7.2.2.13 Na+/K+-exchanging ATPase cerebral cortex - 246958, 246966, 688017, 690001, 695408, 700430, 701165