3.4.22.52 3T3-L1 cell - 707364 3.4.22.52 A-549 cell - 708761 3.4.22.52 A-549 cell protein phosphatase 2A functions as a physiological calpain phosphatase to directly dephosphorylate mu-calpain, which leads to decreased calpain activity and suppression of migration and invasion of human lung cancer cells 680713 3.4.22.52 adipocyte - 707364 3.4.22.52 AGS cell - 707373 3.4.22.52 ameloblast - 707296 3.4.22.52 aorta - 708018 3.4.22.52 aortic endothelial cell - 679684, 700880 3.4.22.52 ASTC-a-1 cell - 708761 3.4.22.52 blood platelet activation of mu-calpain in platelets from patients with type 2 diabetes mellitus 679254 3.4.22.52 brain - 643979, 667136, 678984, 708437, 709152, 718096, 731222, 755619 3.4.22.52 brain penumbra 700426 3.4.22.52 brain white matter from patients with MS and Parkinson‘s and Alzheimer‘s diseases and white matter from normal control 643992 3.4.22.52 brain white matter of young, middle aged and old monkeys, age-dependent myelin degeneration and proteolysis of oligodendrocyte proteins is associated with the activation of calpain-1 643995 3.4.22.52 brain cortex - 700426 3.4.22.52 breast cancer cell - 710164 3.4.22.52 BT-474 cell - 710164 3.4.22.52 C2C12 cell - 695462, 697162 3.4.22.52 C6 glioma cell - 644002 3.4.22.52 Caco-2/TC7 cell - 708051 3.4.22.52 cardiac muscle - 643979 3.4.22.52 cardiomyocyte - 708014, 708015, 708016, 731364 3.4.22.52 carotid atherosclerotic plaque - 707874 3.4.22.52 cerebellum - 709152 3.4.22.52 cerebral cortex - 643998, 680913 3.4.22.52 cerebral cortical neuron - 708434 3.4.22.52 cerebral white matter - 643992 3.4.22.52 cerebral white matter white matter of young, middle aged and old monkeys, age-dependent myelin degeneration and proteolysis of oligodendrocyte proteins is associated with the activation of calpain-1 643995 3.4.22.52 colonic adenocarcinoma cell - 707373 3.4.22.52 cornu ammonis - 707398 3.4.22.52 cornu ammonis area 1 707398 3.4.22.52 corpus striatum - 700426 3.4.22.52 COS-7 cell - 680185 3.4.22.52 CW-2 cell - 707373 3.4.22.52 decidua from patients with recurrent miscarriage and healthy women with informed consent 677501 3.4.22.52 dental lamina - 707296 3.4.22.52 dentin - 707296 3.4.22.52 diaphragm - 707082 3.4.22.52 enamel epithelium - 707296 3.4.22.52 endothelial cell - 708018 3.4.22.52 endothelial cell from aorta 644001 3.4.22.52 erythrocyte - 643975, 643976, 643983, 643989, 643991, 643994, 643997, 669201, 707053, 707559, 708028, 708892, 709438, 709599, 710561, 732676 3.4.22.52 erythrocyte nucleated 643986 3.4.22.52 Fanconi anemia disease specific cell type - 707532 3.4.22.52 Fanconi anemia lymphoid cell line - 707532 3.4.22.52 Fanconi anemia-A cell - 707532 3.4.22.52 Fanconi anemia-C cell - 707532 3.4.22.52 Fanconi anemia-D2 cell - 707532 3.4.22.52 Fanconi anemia-F cell - 707532 3.4.22.52 Fanconi anemia-G cell - 707532 3.4.22.52 fibroblast - 699654, 710561 3.4.22.52 G-361 cell - 709406 3.4.22.52 gastric adenocarcinoma cell - 707373 3.4.22.52 gizzard low level 679333 3.4.22.52 gizzard smooth muscle - 731848 3.4.22.52 GM-3299 cell - 707532 3.4.22.52 H9c2 cell - 731364 3.4.22.52 HaCaT cell - 708745 3.4.22.52 heart - 644005, 707065, 717201, 718096, 753389 3.4.22.52 heart muscle - 643983 3.4.22.52 HEK-293T cell - 708745 3.4.22.52 HEK-TrkB cell - 709641 3.4.22.52 HeLa cell - 708745, 732787 3.4.22.52 hepatocyte - 709967 3.4.22.52 hippocampus - 708438, 709624, 731589 3.4.22.52 HN-30 cell - 708745 3.4.22.52 HT-1080 cell - 708745 3.4.22.52 Huh-7 cell - 708643 3.4.22.52 HUVEC cell - 707373, 709720 3.4.22.52 inner ear - 717453 3.4.22.52 JURKAT cell - 718111 3.4.22.52 kidney - 643979, 643983, 643984, 679333, 690381, 718096 3.4.22.52 KLE cell - 708745 3.4.22.52 Kupffer cell - 709967 3.4.22.52 lens - 707136 3.4.22.52 lens calpain 1 is most abundant in cells near the lens surface 709015 3.4.22.52 lens from Shumiya cataract animals 644000 3.4.22.52 LHCN-M2 cell - 708416 3.4.22.52 liver - 643977, 690381, 707281, 707559, 708435, 718096 3.4.22.52 liver prednisolone suppresses ischemia-reperfusion injury of the rat liver. Its cytoprotective effect is partial, but is closely associated with inhibition of activation of mu-calpain and suppression of IL-beta and TNF-alphatranscription as well as with improved survival rate 643996 3.4.22.52 longissimus postmortem muscle 643999 3.4.22.52 longissimus lumborum loss of activity during postmortem aging 644004 3.4.22.52 longissimus thoracis loss of activity during postmortem aging 644004 3.4.22.52 lung - 679333, 718096 3.4.22.52 lung adenocarcinoma cell - 708761 3.4.22.52 lymphatic endothelial cell - 731892 3.4.22.52 lymphatic microvascular dermal-derived endothelial cell - 731892 3.4.22.52 M93-047 cell - 709406 3.4.22.52 macrophage - 708717 3.4.22.52 MCF-7 cell - 717187 3.4.22.52 MCF-7 cell small interfering RNAs-mediate knockdown of mu-calpain expression in MCF-7 cells that do not express m-calpain leads to a reduction of cell migration 679823 3.4.22.52 MDA-MB-231 cell - 717187 3.4.22.52 MEF cell - 710042, 717198, 731339 3.4.22.52 melanoma cell - 709406 3.4.22.52 MH7A cell rheumatic synovial cell line. mu-calpain, regulates MMP-3 release by rheumatic synovial cells, in addition to exerting its own degradative action on cartilage 677919 3.4.22.52 molaris first molar of foetal ICR mice from embryonic day 14 to postnatal day 7 707296 3.4.22.52 MOLT-4 cell - 718111 3.4.22.52 additional information not detected in testis 718096 3.4.22.52 additional information Plasmodium falciparum-calpain is expressed in all erythrocytic stages, the expression of Plasmodium falciparum-calpain is increased much more when the late ring matures into the early trophozoite -, 708442 3.4.22.52 muscle - 679332, 708215, 709712, 709797, 731990 3.4.22.52 muscle calpains are autolyzed in the early stage of skeletal muscle atrophy. Calpain 1 autolysis occurs without any modification in the total amount. Calpain autolysis is only seen in the slow soleus muscle, while the fast plantaris muscle is not affected. Calpain autolysis and caspase 3 activation found in the soleus muscle could explain a more atrophied condition of this muscle compared with the plantaris muscle 677455 3.4.22.52 muscle low level 679333 3.4.22.52 muscle mu-calpain rapidly loses their activity during postmortem storage, so that proteolytic activity of mu-calpain is nearly zero after 3 d postmortem, even when assayed at pH 7.5 and 25°C 680394 3.4.22.52 muscle musculus longissimus thoracis et lumborum, loss of activity during postmortem aging 644004 3.4.22.52 muscle musculus longissimus, postmortem muscle 643999 3.4.22.52 N-27 cell - 707936 3.4.22.52 NCCIT cell - 708745 3.4.22.52 neural stem cell - 732688 3.4.22.52 neuron - 707281, 707398, 709624 3.4.22.52 neuronal cell line progenitor HCN-A94-2 696451 3.4.22.52 neutrophil - 669300, 752650 3.4.22.52 NT2-Rho0 cell - 710069 3.4.22.52 NTERA-2 cell - 708745 3.4.22.52 odontoblast - 707296 3.4.22.52 oral epithelium - 707296 3.4.22.52 ovary - 718096 3.4.22.52 pancreas - 708781 3.4.22.52 parotid gland the large catalytic subunits of calpains 1 and the small regulatory subunit common to calpains 1 and 2 are weakly expressed in the parotid gland, sublingual gland, and submandibular gland at similar levels in males and females 752607 3.4.22.52 PBMC NO-induced motility in osteoclasts requires regulated Ca2+ release, which activates mu-calpain. This occurs via the inositol (1,4,5)-trisphosphate receptor 1 681012 3.4.22.52 PC-12 cell - 644006, 710409 3.4.22.52 pectoral muscle - 754631 3.4.22.52 periurethral tissue - 708806 3.4.22.52 PK-15 cell originated from kidney 643983 3.4.22.52 placenta - 643967, 643985 3.4.22.52 polymorphonuclear leukocyte - 643981 3.4.22.52 primary cell - 709406 3.4.22.52 psoas psoas major, loss of activity during postmortem aging 644004 3.4.22.52 pulmonary artery smooth muscle - 677829 3.4.22.52 pulmonary microvascular endothelial cell - 709857 3.4.22.52 RAW264.7 cell - 669371 3.4.22.52 red muscle - 644005 3.4.22.52 reticulum trabeculare elevated levels of calpain-1 in glaucomatous trabecular meshwork. However, calpain activity in glaucomatous trabecular meshwork is only about 50% of that in controls. Modification by iso-levuglandins renders calpain-1 inactive 678348 3.4.22.52 retina - 643974, 643982, 709681, 731339 3.4.22.52 retinal ganglion cell - 754896 3.4.22.52 retinal microvascular endothelial cell - 709652 3.4.22.52 rhabdomyosarcoma cell - 708416 3.4.22.52 SCC-13 cell - 708745 3.4.22.52 schizont - -, 708442 3.4.22.52 semitendinosus muscle loss of activity during postmortem aging 644004 3.4.22.52 SH-SY5Y cell neuroblastoma 680913 3.4.22.52 SK-BR-3 cell - 710164 3.4.22.52 skeletal muscle - 643972, 643979, 643980, 643983, 643988, 644001, 667778, 669060, 669062, 670009, 697687, 707143, 708901, 709798, 709800, 718096 3.4.22.52 skeletal muscle autolysis of both mu-calpain and calpain-3 is tightly regulated by Ca2+ concentration in skeletal muscle across a range close to but evidently above that reached during normal activity 663588 3.4.22.52 skeletal muscle excentric exercise produces little autolytic activation of mu-calapin 680421 3.4.22.52 skeletal muscle in skeletal muscle, mu-calpain is a freely diffusible protein 708194 3.4.22.52 skeletal muscle localisation in the Z-band and under the plasma membrane 680185 3.4.22.52 skeletal muscle musculus sternomandibularis 696290 3.4.22.52 skeletal muscle satellite cell - 731906 3.4.22.52 skin - 718096 3.4.22.52 smooth muscle - 644005, 707281 3.4.22.52 sperm - 718386 3.4.22.52 spermatozoon - 644003 3.4.22.52 spinal cord - 709152, 710087, 731222 3.4.22.52 spleen - 643983, 643984, 718096 3.4.22.52 stellate reticulum - 707296 3.4.22.52 stratum intermedium - 707296 3.4.22.52 sublingual gland the large catalytic subunits of calpains 1 and the small regulatory subunit common to calpains 1 and 2 are weakly expressed in the parotid gland, sublingual gland, and submandibular gland at similar levels in males and females 752607 3.4.22.52 submandibular gland - 643983, 643984 3.4.22.52 submandibular gland the large catalytic subunits of calpains 1 and the small regulatory subunit common to calpains 1 and 2 are weakly expressed in the parotid gland, sublingual gland, and submandibular gland at similar levels in males and females 752607 3.4.22.52 testis - 718096 3.4.22.52 thymus - 643983 3.4.22.52 trophozoite - -, 708442 3.4.22.52 U2-OS cell - 710561 3.4.22.52 UACC-647 cell - 709406 3.4.22.52 UACC-903 cell - 709406 3.4.22.52 umbilical vein endothelial cell - 707373 3.4.22.52 vascular smooth muscle - 700880 3.4.22.52 vastus lateralis - 697687