3.4.22.16	evolution	cathepsin H is a member of the papain superfamily of lysosomal cysteine proteases	755176	
3.4.22.16	malfunction	cathepsin H-deficient mice show no gross phenotype and their development is normal without growth retardation. Broncho-alveolar lavage from cathepsin H-deficient mice contain lower levels of pulmonary surfactant protein B	718296	
3.4.22.16	malfunction	knockout of the cathepsin H gene results in 50% reduction of (Met)enkephalin in mouse brain. Cathepsin H deficient mice also show a substantial 80% decrease in galanin peptide neurotransmitter levels in brain	732360	
3.4.22.16	malfunction	loss of CTSH inhibits filaggrin processing, but not expression, and impairs epidermal barrier function, evidence for compensation in CTSH knockout	753961	
3.4.22.16	malfunction	lymphocytes deficient in CatH are still capable of generating active granzyme B. CatH-deficient mice do not show a gross morphological phenotype and no impairment of reproductive capacity or breeding behavior or nursing	709114	
3.4.22.16	malfunction	reduced filaggrin processing and impaired epidermal barrier in CTSH-deficient mouse skin, histology of Ctsh-/-, Ctsh+/-, and wild-type mouse neonatal skin, overview. Loss of CTSH increases skin macrophage counts, mast cell degranulation, and proinflammatory molecule expression. Loss of CTSH inhibits filaggrin processing, but not expression, and impairs epidermal barrier function, evidence for compensation in CTSH knockout	-, 753961	
3.4.22.16	malfunction	specific inhibition of cathepsin H increases the activation of alphabeta3-integrin on PC-3 cells	732111	
3.4.22.16	metabolism	phosphoinositide 3-kinase signaling through AKT1 is required for the proteolytic processing of filaggrin during late epidermal terminal differentiation	-, 753961	
3.4.22.16	additional information	the catalytic triad residues Cys26, His166 and Asn186 of procathepsin H reside in the active site cleft	755176	
3.4.22.16	physiological function	CatB3 is a major protease antigen in Fasciola gigantica metacercariae and newly excysted juveniles	707007