3.4.22.B50	FTKLAGGKISFS + H2O	-	
3.4.22.B50	additional information	the enzyme is one of three distinct viral proteases (PLP1, PLP2 and 3CLpro) involved in processing of the replicase polyprotein	
3.4.22.B50	polyubiquitin + H2O	the enzyme cleaves Lys48- and Lys63-linked polyubiquitin to monoubiquitin but not linear polyubiquitin	
3.4.22.B50	replicase polyprotein + H2O	PLP2 cleaves a substrate encoding the first predicted membrane-spanning domain, MP1, of the replicase polyprotein. Processing the replicase polyprotein at this site generates the p150 replicase intermediate that is likely critical for embedding the replicase complex into cellular membranes. The enzyme acts efficiently in trans	
3.4.22.B50	ubiquitin + H2O	-	
3.4.22.B50	ubiquitin + H2O	the enzyme cleaves the LRGG tail of ubiquitin	
3.4.22.B50	ubiquitin + H2O	the enzyme processes both K-48 and K-63 linked polyubiquitin chains	
3.4.22.B50	ubiquitinated RIG-I + H2O	-	
3.4.22.B50	ubiquitinated STING + H2O	-	
3.4.22.B50	VAKQGAGFKRTY + H2O	-