Literature summary extracted from
van Kasteren, P.B.; Knaap, R.C.; van den Elzen, P.; Snijder, E.J.; Balasuriya, U.B.; van den Born, E.; Kikkert, M.
In vivo assessment of equine arteritis virus vaccine improvement by disabling the deubiquitinase activity of papain-like protease 2 (2015), Vet. Microbiol., 178, 132-137 .
Application
EC Number |
Application |
Comment |
Organism |
---|
3.4.22.B50 |
medicine |
vaccination of Shetland mares, either with deubiquitinase DUB-positive or DUB-negative recombinant equine arteritis virus. Upon challenge with the virulent KY84 strain of equine arteritis virus, both vaccine viruses proved to be replication competent in vivo. The DUB-negative virus provides a similar degree of protection against clinical disease as its DUB-positive parental counterpart. A possible improvement due to inactivation of PLP2 DUB activity could not be detected under these experimental conditions |
equine arteritis virus |
Protein Variants
EC Number |
Protein Variants |
Comment |
Organism |
---|
3.4.22.B50 |
T312A/I313V/I353R |
mutant lacks deubiquitinase activity, amino acid numbering based on polyprotein |
equine arteritis virus |
Organism
EC Number |
Organism |
UniProt |
Comment |
Textmining |
---|
3.4.22.B50 |
equine arteritis virus |
P19811 |
polyprotein |
- |
3.4.22.B50 |
equine arteritis virus Bucyrus |
P19811 |
polyprotein |
- |