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Literature summary extracted from

  • Chen, J.; Wang, D.; Sun, Z.; Gao, L.; Zhu, X.; Guo, J.; Xu, S.; Fang, L.; Li, K.; Xiaoa, S.
    Arterivirus nsp4 antagonizes interferon beta production by proteolytically cleaving NEMO at multiple sites (2019), J. Virol., 93, e00385 .
    View publication on PubMedView publication on EuropePMC

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.114 equine arteritis virus
-
-
-
3.4.21.114 porcine reproductive and respiratory syndrome virus E3V2B5 PRRSV
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.114 NF-kappaB essential modulator NEMO + H2O
-
 equine arteritis virus ?
-
 ?
3.4.21.114 NF-kappaB essential modulator NEMO + H2O
-
 porcine reproductive and respiratory syndrome virus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.114 nsp4
-
 equine arteritis virus
3.4.21.114 nsp4
-
 porcine reproductive and respiratory syndrome virus

General Information

EC Number General Information Comment Organism
3.4.21.114 physiological function nsp4 inhibits virus-induced IFN-beta production by targeting NF-kappaB essential modulator NEMO for proteolytic cleavage. The scission occurs at sites E166, E171, Q205, and E349 equine arteritis virus
3.4.21.114 physiological function nsp4 inhibits virus-induced IFN-beta production by targeting NF-kappaB essential modulator NEMO for proteolytic cleavage. The scission occurs at sites E166, E171, Q205, and E349. NEMO cleavage at E349 alone may not be sufficient to completely inactivate the interferon response via this signaling adaptor porcine reproductive and respiratory syndrome virus