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Literature summary extracted from

  • Zhou, J.; Fang, L.; Yang, Z.; Xu, S.; Lv, M.; Sun, Z.; Chen, J.; Wang, D.; Gao, J.; Xiao, S.
    Identification of novel proteolytically inactive mutations in coronavirus 3C-like protease using a combined approach (2019), FASEB J., 33, 14575-14587 .
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
3.4.22.69 F139A loss in protease activity. Significant disruption of the intermolecular hydrogen bonding network and intermolecular dynamic correlations for the active sites, thus affecting the intermolecular hydrogen bond network and the substrate binding affinity porcine epidemic diarrhea virus
3.4.22.69 G142A loss in protease activity. Significant disruption of the intermolecular hydrogen bonding network and intermolecular dynamic correlations for the active sites, thus affecting the intermolecular hydrogen bond network and the substrate binding affinity porcine epidemic diarrhea virus
3.4.22.69 H162A loss in protease activity. Significant disruption of the intermolecular hydrogen bonding network and intermolecular dynamic correlations for the active sites, thus affecting the intermolecular hydrogen bond network and the substrate binding affinity porcine epidemic diarrhea virus
3.4.22.69 W31A loss in protease activity. Mutation might cause subtle but significant rearrangements in the structure resulting in altered interactions with the bound substrate, as well as impacting the dynamic assemblies of the complexes porcine epidemic diarrhea virus

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.69 porcine epidemic diarrhea virus
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Synonyms

EC Number Synonyms Comment Organism
3.4.22.69 3cLpro
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 porcine epidemic diarrhea virus