Literature summary extracted from

Ratia, K.; Saikatendu, K.S.; Santarsiero, B.D.; Barretto, N.; Baker, S.C.; Stevens, R.C.; Mesecar, A.D.
Severe acute respiratory syndrome coronavirus papain-like protease: structure of a viral deubiquitinating enzyme (2006), Proc. Natl. Acad. Sci. USA, 103, 5717-5722.

Application

EC Number	Application	Comment	Organism
3.4.22.B50	medicine	PLpro is an important target for development of antiviral drugs that would inhibit viral replication and reduce mortality associated with outbreaks of SARS-CoV	Alphacoronavirus

Crystallization (Commentary)

EC Number	Crystallization (Comment)	Organism
3.4.22.B50	hanging-drop vapor-diffusion, to 1.85 A resolution, the enzyme has an intact zinc-binding motif, an unobstructed catalytically competent active site and an intriguing, ubiquitin-like N-terminal domain	Alphacoronavirus

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.4.22.B50	Alphacoronavirus	-	SARS-CoV	-
3.4.22.B50	Alphacoronavirus SARS-CoV	-	SARS-CoV	-

Subunits

EC Number	Subunits	Comment	Organism
3.4.22.B50	monomer	-	Alphacoronavirus

Synonyms

EC Number	Synonyms	Comment	Organism
3.4.22.B50	papain-like proteinase	-	Alphacoronavirus
3.4.22.B50	PLpro	-	Alphacoronavirus

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)