Reference to 3.4.22.B50; Id = 755638 - BRENDA Enzyme Database

medicine

vaccination of Shetland mares, either with deubiquitinase DUB-positive or DUB-negative recombinant equine arteritis virus. Upon challenge with the virulent KY84 strain of equine arteritis virus, both vaccine viruses proved to be replication competent in vivo. The DUB-negative virus provides a similar degree of protection against clinical disease as its DUB-positive parental counterpart. A possible improvement due to inactivation of PLP2 DUB activity could not be detected under these experimental conditions

equine arteritis virus

T312A/I313V/I353R

mutant lacks deubiquitinase activity, amino acid numbering based on polyprotein

equine arteritis virus

P19811

polyprotein

-

equine arteritis virus Bucyrus

P19811

polyprotein

-

medicine

vaccination of Shetland mares, either with deubiquitinase DUB-positive or DUB-negative recombinant equine arteritis virus. Upon challenge with the virulent KY84 strain of equine arteritis virus, both vaccine viruses proved to be replication competent in vivo. The DUB-negative virus provides a similar degree of protection against clinical disease as its DUB-positive parental counterpart. A possible improvement due to inactivation of PLP2 DUB activity could not be detected under these experimental conditions

equine arteritis virus

T312A/I313V/I353R

mutant lacks deubiquitinase activity, amino acid numbering based on polyprotein

equine arteritis virus

752517

Chu

Porcine epidemic diarrhea vir ...

porcine epidemic diarrhea virus

Antiviral Res.

158

199-205

2018

-

1

-

2

4

-

1

-

1

-

3

1

-

4

-

1

-

2

-

1

-

1

-

2

1

4

-

1

-

3

1

-

4

-

4

731149

Baez-Santos

The SARS-coronavirus papain-li ...

Severe acute respiratory syndrome-related coronavirus

Antiviral Res.

115

21-38

2015

-

1

-

1

-

20

-

2

-

5

-

1

-

4

-

1

-

16

-

1

-

1

-

16

20

1

-

2

-

2

-

732186

Kong

Structural view and substrate ...

infectious bronchitis virus

J. Biol. Chem.

290

7160-7168

2015

-

1

-

2

-

1

-

1

-

1

-

4

-

1

-

1

-

1

-

2

-

1

-

1

-

4

-

754545

Mielech

Murine coronavirus ubiquitin- ...

Murine coronavirus

J. Virol.

89

4907-4917

2015

-

1

-

1

-

1

-

755638

van Kasteren

In vivo assessment of equine ...

equine arteritis virus, equine arteritis virus Bucyrus

Vet. Microbiol.

178

132-137

2015

-

1

-

1

-

3

-

1

-

1

-

731069

Chou

Structural basis for catalysis ...

Severe acute respiratory syndrome-related coronavirus

Acta Crystallogr. Sect. D

70

572-581

2014

-

1

9

-

3

9

-

3

-

1

-

2

-

3

1

-

8

1

-

2

-

1

-

1

9

-

3

2

9

-

1

-

2

-

1

-

8

1

-

3

-

8

732257

Xing

The papain-like protease of po ...

porcine epidemic diarrhea virus

J. Gen. Virol.

94

1554-1567

2013

-

1

-

3

-

3

-

1

-

3

-

1

-

1

-

3

-

3

-

3

-

1

-

732725

Dutta

Enhancement of proteolytic act ...

Tabernaemontana divaricata

PLoS ONE

8

e62619

2013

1

-

1

-

3

-

1

4

-

1

-

3

-

1

-

1

-

4

-

3

1

2

1

-

1

4

1

-

4

1

-

1

-

3

-

4

1

-

4

-

1

-

1

-

4

-

3

1

-

1

4

1

-

4

732827

van Kasteren

Deubiquitinase function of art ...

equine arteritis virus

Proc. Natl. Acad. Sci. USA

110

E838-E847

2013

-

1

4

-

1

-

1

-

1

-

1

-

3

-

1

-

1

-

1

4

-

1

-

1

-

1

-

3

-

2

-

6

718000

Chaudhuri

Comparison of SARS and NL63 pa ...

Human coronavirus NL63

J. Mol. Biol.

414

272-288

2011

-

1

-

3

-

1

-

3

-

1

-

1

-

3

-

3

-

718275

Wang

PLP2 of mouse hepatitis virus ...

Murine hepatitis virus

PLoS ONE

6

e17192

2011

-

1

-

1

-

1

-

3

-

2

-

1

-

1

-

1

-

1

-

718347

Sun

-

Deubiquitinase activity and re ...

Human coronavirus NL63

Prog. Biochem. Biophys.

37

871-880

2010

-

1

-

2

-

1

-

2

-

1

-

681685

Ziebuhr

Human coronavirus 229E papain- ...

Human coronavirus 229E

J. Virol.

81

3922-3932

2007

-

2

-

1

-

2

-

1

-

681691

Chen

Proteolytic processing and deu ...

Human coronavirus NL63

J. Virol.

81

6007-6018

2007

-

1

-

1

-

1

-

1

-

670702

Ratia

Severe acute respiratory syndr ...

Alphacoronavirus, Alphacoronavirus SARS-CoV

Proc. Natl. Acad. Sci. USA

103

5717-5722

2006

-

1

-

1

-

7

-

1

2

-

1

-

1

-

1

-

667619

Han

Papain-like protease 2 (PLP2) ...

Alphacoronavirus, Alphacoronavirus SARS-CoV

Biochemistry

44

10349-10359

2005

-

1

-

5

9

-

2

-

5

-

1

-

12

1

2

-

1

9

1

-

1

-

5

-

9

-

2

-

1

-

12

1

-

1

9

1

-

670084

Barretto

The papain-like protease of se ...

Alphacoronavirus, Alphacoronavirus SARS-CoV

J. Virol.

79

15189-15198

2005

-

1

-

3

-

1

-

6

-

1

-

1

6

-

2

-

1

-

3

-

1

-

1

-

1

6

-

670085

Lindner

The papain-like protease from ...

Alphacoronavirus, Alphacoronavirus SARS-CoV

J. Virol.

79

15199-15208

2005

-

1

-

1

-

1

-

3

-

9

-

1

-

2

8

-

2

-

1

-

1

-

1

-

1

-

3

-

1

-

2

8

-

668774

Kanjanahaluethai

-

Coronavirus papain-like endope ...

Alphacoronavirus

Handbook of Proteolytic Enzymes (Barrett, A. J. , Rawlings, N. D. , Woessner, J. F. , eds. )Academic Press

2

1265-1269

2004

-

1

-

1

-

1

-

1

-

2

-

1

-

1

-

1

-

647692

Kanjanahaluethai

Identification of mouse hepati ...

Murine coronavirus

J. Virol.

74

7911-7921

2000

-

1

-

1

-

2

-

4

-

3

-

1

-

1

-

2

-

3

-

647410

Teng

Expression of murine coronavir ...

Murine coronavirus

J. Virol.

73

2658-2666

1999

-

6

-

1

-

1

-

In vivo assessment of equine arteritis virus vaccine improvement by disabling the deubiquitinase activity of papain-like protease 2

Data extracted from this reference: