Reference to 3.4.22.B50; Id = 732257 - BRENDA Enzyme Database

expressed in HEK-293T cells

porcine epidemic diarrhea virus

C1729A

the mutant shows reduced interferon antagonistic activity compared to that of the wild type enzyme

porcine epidemic diarrhea virus

D1901A

the mutant almost completely loses interferon antagonistic activity compared to that of the wild type enzyme

porcine epidemic diarrhea virus

H1888A

the mutant almost completely loses interferon antagonistic activity compared to that of the wild type enzyme

porcine epidemic diarrhea virus

ubiquitin + H2O

porcine epidemic diarrhea virus

the enzyme processes both K-48 and K-63 linked polyubiquitin chains

?

-

?

ubiquitinated RIG-I + H2O

porcine epidemic diarrhea virus

-

deubiquitinated RIG-I + ubiquitin

-

?

ubiquitinated STING + H2O

porcine epidemic diarrhea virus

-

deubiquitinated STING + ubiquitin

-

?

porcine epidemic diarrhea virus

P0C6Y4

-

ubiquitin + H2O

the enzyme processes both K-48 and K-63 linked polyubiquitin chains

732257

porcine epidemic diarrhea virus

?

-

?

ubiquitinated RIG-I + H2O

-

732257

porcine epidemic diarrhea virus

deubiquitinated RIG-I + ubiquitin

-

?

ubiquitinated STING + H2O

-

732257

porcine epidemic diarrhea virus

deubiquitinated STING + ubiquitin

-

?

PLP2

-

porcine epidemic diarrhea virus

expressed in HEK-293T cells

porcine epidemic diarrhea virus

C1729A

the mutant shows reduced interferon antagonistic activity compared to that of the wild type enzyme

porcine epidemic diarrhea virus

D1901A

the mutant almost completely loses interferon antagonistic activity compared to that of the wild type enzyme

porcine epidemic diarrhea virus

H1888A

the mutant almost completely loses interferon antagonistic activity compared to that of the wild type enzyme

porcine epidemic diarrhea virus

ubiquitin + H2O

porcine epidemic diarrhea virus

the enzyme processes both K-48 and K-63 linked polyubiquitin chains

?

-

?

ubiquitinated RIG-I + H2O

porcine epidemic diarrhea virus

-

deubiquitinated RIG-I + ubiquitin

-

?

ubiquitinated STING + H2O

porcine epidemic diarrhea virus

-

deubiquitinated STING + ubiquitin

-

?

ubiquitin + H2O

the enzyme processes both K-48 and K-63 linked polyubiquitin chains

732257

porcine epidemic diarrhea virus

?

-

?

ubiquitinated RIG-I + H2O

-

732257

porcine epidemic diarrhea virus

deubiquitinated RIG-I + ubiquitin

-

?

ubiquitinated STING + H2O

-

732257

porcine epidemic diarrhea virus

deubiquitinated STING + ubiquitin

-

?

physiological function

the enzyme strongly inhibits RIG-Iand STING-activated interferon expression. Papain-like protease 2 acts as a viral deubiquitinase to interfere with the RIG-I- and STING-mediated signalling pathway

porcine epidemic diarrhea virus

physiological function

the enzyme strongly inhibits RIG-Iand STING-activated interferon expression. Papain-like protease 2 acts as a viral deubiquitinase to interfere with the RIG-I- and STING-mediated signalling pathway

porcine epidemic diarrhea virus

752517

Chu

Porcine epidemic diarrhea vir ...

porcine epidemic diarrhea virus

Antiviral Res.

158

199-205

2018

-

1

-

2

4

-

1

-

1

-

3

1

-

4

-

1

-

2

-

1

-

1

-

2

1

4

-

1

-

3

1

-

4

-

4

731149

Baez-Santos

The SARS-coronavirus papain-li ...

Severe acute respiratory syndrome-related coronavirus

Antiviral Res.

115

21-38

2015

-

1

-

1

-

20

-

2

-

5

-

1

-

4

-

1

-

16

-

1

-

1

-

16

20

1

-

2

-

2

-

732186

Kong

Structural view and substrate ...

infectious bronchitis virus

J. Biol. Chem.

290

7160-7168

2015

-

1

-

2

-

1

-

1

-

1

-

4

-

1

-

1

-

1

-

2

-

1

-

1

-

4

-

754545

Mielech

Murine coronavirus ubiquitin- ...

Murine coronavirus

J. Virol.

89

4907-4917

2015

-

1

-

1

-

1

-

755638

van Kasteren

In vivo assessment of equine ...

equine arteritis virus, equine arteritis virus Bucyrus

Vet. Microbiol.

178

132-137

2015

-

1

-

1

-

3

-

1

-

1

-

731069

Chou

Structural basis for catalysis ...

Severe acute respiratory syndrome-related coronavirus

Acta Crystallogr. Sect. D

70

572-581

2014

-

1

9

-

3

9

-

3

-

1

-

2

-

3

1

-

8

1

-

2

-

1

-

1

9

-

3

2

9

-

1

-

2

-

1

-

8

1

-

3

-

8

732257

Xing

The papain-like protease of po ...

porcine epidemic diarrhea virus

J. Gen. Virol.

94

1554-1567

2013

-

1

-

3

-

3

-

1

-

3

-

1

-

1

-

3

-

3

-

3

-

1

-

732725

Dutta

Enhancement of proteolytic act ...

Tabernaemontana divaricata

PLoS ONE

8

e62619

2013

1

-

1

-

3

-

1

4

-

1

-

3

-

1

-

1

-

4

-

3

1

2

1

-

1

4

1

-

4

1

-

1

-

3

-

4

1

-

4

-

1

-

1

-

4

-

3

1

-

1

4

1

-

4

732827

van Kasteren

Deubiquitinase function of art ...

equine arteritis virus

Proc. Natl. Acad. Sci. USA

110

E838-E847

2013

-

1

4

-

1

-

1

-

1

-

1

-

3

-

1

-

1

-

1

4

-

1

-

1

-

1

-

3

-

2

-

6

718000

Chaudhuri

Comparison of SARS and NL63 pa ...

Human coronavirus NL63

J. Mol. Biol.

414

272-288

2011

-

1

-

3

-

1

-

3

-

1

-

1

-

3

-

3

-

718275

Wang

PLP2 of mouse hepatitis virus ...

Murine hepatitis virus

PLoS ONE

6

e17192

2011

-

1

-

1

-

1

-

3

-

2

-

1

-

1

-

1

-

1

-

718347

Sun

-

Deubiquitinase activity and re ...

Human coronavirus NL63

Prog. Biochem. Biophys.

37

871-880

2010

-

1

-

2

-

1

-

2

-

1

-

681685

Ziebuhr

Human coronavirus 229E papain- ...

Human coronavirus 229E

J. Virol.

81

3922-3932

2007

-

2

-

1

-

2

-

1

-

681691

Chen

Proteolytic processing and deu ...

Human coronavirus NL63

J. Virol.

81

6007-6018

2007

-

1

-

1

-

1

-

1

-

670702

Ratia

Severe acute respiratory syndr ...

Alphacoronavirus, Alphacoronavirus SARS-CoV

Proc. Natl. Acad. Sci. USA

103

5717-5722

2006

-

1

-

1

-

7

-

1

2

-

1

-

1

-

1

-

667619

Han

Papain-like protease 2 (PLP2) ...

Alphacoronavirus, Alphacoronavirus SARS-CoV

Biochemistry

44

10349-10359

2005

-

1

-

5

9

-

2

-

5

-

1

-

12

1

2

-

1

9

1

-

1

-

5

-

9

-

2

-

1

-

12

1

-

1

9

1

-

670084

Barretto

The papain-like protease of se ...

Alphacoronavirus, Alphacoronavirus SARS-CoV

J. Virol.

79

15189-15198

2005

-

1

-

3

-

1

-

6

-

1

-

1

6

-

2

-

1

-

3

-

1

-

1

-

1

6

-

670085

Lindner

The papain-like protease from ...

Alphacoronavirus, Alphacoronavirus SARS-CoV

J. Virol.

79

15199-15208

2005

-

1

-

1

-

1

-

3

-

9

-

1

-

2

8

-

2

-

1

-

1

-

1

-

1

-

3

-

1

-

2

8

-

668774

Kanjanahaluethai

-

Coronavirus papain-like endope ...

Alphacoronavirus

Handbook of Proteolytic Enzymes (Barrett, A. J. , Rawlings, N. D. , Woessner, J. F. , eds. )Academic Press

2

1265-1269

2004

-

1

-

1

-

1

-

1

-

2

-

1

-

1

-

1

-

647692

Kanjanahaluethai

Identification of mouse hepati ...

Murine coronavirus

J. Virol.

74

7911-7921

2000

-

1

-

1

-

2

-

4

-

3

-

1

-

1

-

2

-

3

-

647410

Teng

Expression of murine coronavir ...

Murine coronavirus

J. Virol.

73

2658-2666

1999

-

6

-

1

-

1

-

The papain-like protease of porcine epidemic diarrhea virus negatively regulates type I interferon pathway by acting as a viral deubiquitinase

Data extracted from this reference: