Literature summary for 3.4.22.B50 extracted from

  • Sun, L.; Yang, Y.; Liu, D.; Xing, Y.; Chen, X.; Chen, Z.
    Deubiquitinase activity and regulation of antiviral innate immune responses by papain-like proteases of human coronavirus NL63 (2010), Prog. Biochem. Biophys., 37, 871-880.
No PubMed abstract available

Organism

Organism UniProt Comment Textmining
Human coronavirus NL63
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the core domain of PLP2 has in vivo deubiquitinase and DeISGylation activity Human coronavirus NL63 ?
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ubiquitinated branched peptides + H2O
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Human coronavirus NL63 ?
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Synonyms

Synonyms Comment Organism
PLP2 papain-like protease core domain 2 is part of non-structural protein 3 Human coronavirus NL63

General Information

General Information Comment Organism
physiological function PLP2 is responsible for the inhibition of both RIG-I and TLR3-dependent induction of interferon alpha/beta expression Human coronavirus NL63