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Literature summary for 3.4.22.B50 extracted from
- PLP2 of mouse hepatitis virus A59 (MHV-A59) targets TBK1 to negatively regulate cellular type I interferon signaling pathway (2011), PLoS ONE, 6, e17192.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in HEK-293T cells | Murine hepatitis virus |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| C106A | inactive | Murine hepatitis virus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | - |
Murine hepatitis virus | 5737 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Murine hepatitis virus | - |
- |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| papain-like protease domain 2 | a catalytic domain of the nonstructural protein 3 of mouse hepatitis virus A59 | Murine hepatitis virus |
| PLP2 | - |
Murine hepatitis virus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | papain-like protease domain 2 (PLP2) deubiquitinates TANK-binding kinase-1 (TBK1) and reduces its kinase activity, hence inhibits interferon-beta reporter activity and prevents interferon regulatory factor 3 (IRF3) nuclear translocation. The presence of PLP2 stabilizes the hypo-phosphorylated IRF3-TBK1 complex in a dose-dependent manner in the cytoplasm | Murine hepatitis virus |
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