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Literature summary for 3.4.22.B50 extracted from

  • Ratia, K.; Saikatendu, K.S.; Santarsiero, B.D.; Barretto, N.; Baker, S.C.; Stevens, R.C.; Mesecar, A.D.
    Severe acute respiratory syndrome coronavirus papain-like protease: structure of a viral deubiquitinating enzyme (2006), Proc. Natl. Acad. Sci. USA, 103, 5717-5722.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.B50

Application

Application Comment Organism
medicine PLpro is an important target for development of antiviral drugs that would inhibit viral replication and reduce mortality associated with outbreaks of SARS-CoV Alphacoronavirus

Crystallization (Commentary)

Crystallization (Comment) Organism
hanging-drop vapor-diffusion, to 1.85 A resolution, the enzyme has an intact zinc-binding motif, an unobstructed catalytically competent active site and an intriguing, ubiquitin-like N-terminal domain Alphacoronavirus

Organism

Organism UniProt Comment Textmining
Alphacoronavirus
-
 SARS-CoV
-
Alphacoronavirus SARS-CoV
-
 SARS-CoV
-

Subunits

Subunits Comment Organism
monomer
-
 Alphacoronavirus

Synonyms

Synonyms Comment Organism
papain-like proteinase
-
 Alphacoronavirus
PLpro
-
 Alphacoronavirus