BRENDA - Enzyme Database
show all sequences of 3.4.22.B50

Papain-like protease 2 (PLP2) from severe acute respiratory syndrome coronavirus (SARS-CoV): expression, purification, characterization, and inhibition

Han, Y.S.; Chang, G.G.; Juo, C.G.; Lee, H.J.; Yeh, S.H.; Hsu, J.T.; Chen, X.; Biochemistry 44, 10349-10359 (2005) View publication on PubMed

Data extracted from this reference:

Application
Application
Commentary
Organism
medicine
antiviral therapy
Alphacoronavirus
Cloned(Commentary)
Cloned (Commentary)
Organism
cloned into modified version of the pBacPAK8/His2 vector and expressed in insect cells Sf9
Alphacoronavirus
Inhibitors
Inhibitors
Commentary
Organism
Structure
Cu2+
weakly inhibited by 70% at 0.01 mM
Alphacoronavirus
hydroxypridine-2-thione Zn
-
Alphacoronavirus
additional information
not inhibited by Mg2+, Mn2+, Ca2+, Ni2+ and Co2+ at 0.01 mM, E64, leupeptin and antipain at 0.1 mM, N-ethylmaleimide and chymostatin at 1 mM and cystatin at 0.01 mg/mL respectively
Alphacoronavirus
N-ethyl-N-phenyldithiocarbaic acid Zn
-
Alphacoronavirus
Zn2+
-
Alphacoronavirus
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.021
-
Abz-FRLKGGAPIKGV-N-(2,4-dinitrophenyl)-ethylenediamine
at pH 5.25
Alphacoronavirus
0.064
-
Abz-FRLKGGAPIKGV-N-(2,4-dinitrophenyl)-ethylenediamine
at pH 6.05
Alphacoronavirus
0.0654
-
Abz-FRLKGGAPIKGV-N-(2,4-dinitrophenyl)-ethylenediamine
at pH 6.82
Alphacoronavirus
0.068
-
Abz-FRLKGGAPIKGV-N-(2,4-dinitrophenyl)-ethylenediamine
at pH 9.2
Alphacoronavirus
0.0704
-
Abz-FRLKGGAPIKGV-N-(2,4-dinitrophenyl)-ethylenediamine
at pH 9.8
Alphacoronavirus
0.0714
-
Abz-FRLKGGAPIKGV-N-(2,4-dinitrophenyl)-ethylenediamine
at pH 8.65
Alphacoronavirus
0.072
-
Abz-FRLKGGAPIKGV-N-(2,4-dinitrophenyl)-ethylenediamine
at pH 8.01
Alphacoronavirus
0.0772
-
Abz-FRLKGGAPIKGV-N-(2,4-dinitrophenyl)-ethylenediamine
at pH 7.42
Alphacoronavirus
0.185
-
FRLKGGAPIKGV
-
Alphacoronavirus
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
51000
-
SDS-PAGE
Alphacoronavirus
56700
-
gel filtration
Alphacoronavirus
Organism
Organism
UniProt
Commentary
Textmining
Alphacoronavirus
-
SARS-CoV
-
Alphacoronavirus SARS-CoV
-
SARS-CoV
-
Purification (Commentary)
Purification (Commentary)
Organism
gel filtration
Alphacoronavirus
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
Abz-FRLKGGAPIKGV-N-(2,4-dinitrophenyl)-ethylenediamine + H2O
fluorogenic substrate
667619
Alphacoronavirus
?
-
-
-
?
Abz-FRLKGGAPIKGV-N-(2,4-dinitrophenyl)-ethylenediamine + H2O
fluorogenic substrate
667619
Alphacoronavirus SARS-CoV
?
-
-
-
?
BCoV substrate
-
667619
Alphacoronavirus
?
-
-
-
?
BCoV substrate
-
667619
Alphacoronavirus SARS-CoV
?
-
-
-
?
FRLKGGAPIKGV
12 mer oligopeptide containing Gly818-Ala819, 100% cleavage
667619
Alphacoronavirus
?
-
-
-
?
FRLKGGAPIKGV
12 mer oligopeptide containing Gly818-Ala819, 100% cleavage
667619
Alphacoronavirus SARS-CoV
?
-
-
-
?
ISLKGGKIVSTC
12 mer oligopeptide containing Gly2740-Lys2741, 29% cleavage
667619
Alphacoronavirus
?
-
-
-
?
ISLKGGKIVSTC
12 mer oligopeptide containing Gly2740-Lys2741, 29% cleavage
667619
Alphacoronavirus SARS-CoV
?
-
-
-
?
MHV substrate
-
667619
Alphacoronavirus
?
-
-
-
?
additional information
SARS-CoV PLP2 does not cleave HCoV.229E and IBV substrates
667619
Alphacoronavirus
?
-
-
-
?
additional information
SARS-CoV PLP2 does not cleave HCoV.229E and IBV substrates
667619
Alphacoronavirus SARS-CoV
?
-
-
-
?
RELNGGAVTRYV + H2O
12 mer oligopeptide containing Gly180-Ala181, 5% cleavage
667619
Alphacoronavirus
AVTYRV + RELNGG
-
-
-
?
Subunits
Subunits
Commentary
Organism
monomer
-
Alphacoronavirus
Synonyms
Synonyms
Commentary
Organism
papain-like protease
-
Alphacoronavirus
PLP2
-
Alphacoronavirus
Temperature Stability [°C]
Temperature Stability Minimum [°C]
Temperature Stability Maximum [°C]
Commentary
Organism
37
-
thermolabil, significantly reduced activity after incubation at temperatures higher than 37°C for 30 min
Alphacoronavirus
Turnover Number [1/s]
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
0.023
-
Abz-FRLKGGAPIKGV-N-(2,4-dinitrophenyl)-ethylenediamine
at pH 5.25
Alphacoronavirus
0.025
-
FRLKGGAPIKGV
-
Alphacoronavirus
0.1
-
Abz-FRLKGGAPIKGV-N-(2,4-dinitrophenyl)-ethylenediamine
at pH 9.8
Alphacoronavirus
0.198
-
Abz-FRLKGGAPIKGV-N-(2,4-dinitrophenyl)-ethylenediamine
at pH 6.05
Alphacoronavirus
0.233
-
Abz-FRLKGGAPIKGV-N-(2,4-dinitrophenyl)-ethylenediamine
at pH 9.2
Alphacoronavirus
0.33
-
Abz-FRLKGGAPIKGV-N-(2,4-dinitrophenyl)-ethylenediamine
at pH 7.42
Alphacoronavirus
0.343
-
Abz-FRLKGGAPIKGV-N-(2,4-dinitrophenyl)-ethylenediamine
at pH 6.82
Alphacoronavirus
0.363
-
Abz-FRLKGGAPIKGV-N-(2,4-dinitrophenyl)-ethylenediamine
at pH 8.01
Alphacoronavirus
0.366
-
Abz-FRLKGGAPIKGV-N-(2,4-dinitrophenyl)-ethylenediamine
at pH 8.65
Alphacoronavirus
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
6.8
8.6
-
Alphacoronavirus
Application (protein specific)
Application
Commentary
Organism
medicine
antiviral therapy
Alphacoronavirus
Cloned(Commentary) (protein specific)
Commentary
Organism
cloned into modified version of the pBacPAK8/His2 vector and expressed in insect cells Sf9
Alphacoronavirus
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
Cu2+
weakly inhibited by 70% at 0.01 mM
Alphacoronavirus
hydroxypridine-2-thione Zn
-
Alphacoronavirus
additional information
not inhibited by Mg2+, Mn2+, Ca2+, Ni2+ and Co2+ at 0.01 mM, E64, leupeptin and antipain at 0.1 mM, N-ethylmaleimide and chymostatin at 1 mM and cystatin at 0.01 mg/mL respectively
Alphacoronavirus
N-ethyl-N-phenyldithiocarbaic acid Zn
-
Alphacoronavirus
Zn2+
-
Alphacoronavirus
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.021
-
Abz-FRLKGGAPIKGV-N-(2,4-dinitrophenyl)-ethylenediamine
at pH 5.25
Alphacoronavirus
0.064
-
Abz-FRLKGGAPIKGV-N-(2,4-dinitrophenyl)-ethylenediamine
at pH 6.05
Alphacoronavirus
0.0654
-
Abz-FRLKGGAPIKGV-N-(2,4-dinitrophenyl)-ethylenediamine
at pH 6.82
Alphacoronavirus
0.068
-
Abz-FRLKGGAPIKGV-N-(2,4-dinitrophenyl)-ethylenediamine
at pH 9.2
Alphacoronavirus
0.0704
-
Abz-FRLKGGAPIKGV-N-(2,4-dinitrophenyl)-ethylenediamine
at pH 9.8
Alphacoronavirus
0.0714
-
Abz-FRLKGGAPIKGV-N-(2,4-dinitrophenyl)-ethylenediamine
at pH 8.65
Alphacoronavirus
0.072
-
Abz-FRLKGGAPIKGV-N-(2,4-dinitrophenyl)-ethylenediamine
at pH 8.01
Alphacoronavirus
0.0772
-
Abz-FRLKGGAPIKGV-N-(2,4-dinitrophenyl)-ethylenediamine
at pH 7.42
Alphacoronavirus
0.185
-
FRLKGGAPIKGV
-
Alphacoronavirus
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
51000
-
SDS-PAGE
Alphacoronavirus
56700
-
gel filtration
Alphacoronavirus
Purification (Commentary) (protein specific)
Commentary
Organism
gel filtration
Alphacoronavirus
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
Abz-FRLKGGAPIKGV-N-(2,4-dinitrophenyl)-ethylenediamine + H2O
fluorogenic substrate
667619
Alphacoronavirus
?
-
-
-
?
Abz-FRLKGGAPIKGV-N-(2,4-dinitrophenyl)-ethylenediamine + H2O
fluorogenic substrate
667619
Alphacoronavirus SARS-CoV
?
-
-
-
?
BCoV substrate
-
667619
Alphacoronavirus
?
-
-
-
?
BCoV substrate
-
667619
Alphacoronavirus SARS-CoV
?
-
-
-
?
FRLKGGAPIKGV
12 mer oligopeptide containing Gly818-Ala819, 100% cleavage
667619
Alphacoronavirus
?
-
-
-
?
FRLKGGAPIKGV
12 mer oligopeptide containing Gly818-Ala819, 100% cleavage
667619
Alphacoronavirus SARS-CoV
?
-
-
-
?
ISLKGGKIVSTC
12 mer oligopeptide containing Gly2740-Lys2741, 29% cleavage
667619
Alphacoronavirus
?
-
-
-
?
ISLKGGKIVSTC
12 mer oligopeptide containing Gly2740-Lys2741, 29% cleavage
667619
Alphacoronavirus SARS-CoV
?
-
-
-
?
MHV substrate
-
667619
Alphacoronavirus
?
-
-
-
?
additional information
SARS-CoV PLP2 does not cleave HCoV.229E and IBV substrates
667619
Alphacoronavirus
?
-
-
-
?
additional information
SARS-CoV PLP2 does not cleave HCoV.229E and IBV substrates
667619
Alphacoronavirus SARS-CoV
?
-
-
-
?
RELNGGAVTRYV + H2O
12 mer oligopeptide containing Gly180-Ala181, 5% cleavage
667619
Alphacoronavirus
AVTYRV + RELNGG
-
-
-
?
Subunits (protein specific)
Subunits
Commentary
Organism
monomer
-
Alphacoronavirus
Temperature Stability [°C] (protein specific)
Temperature Stability Minimum [°C]
Temperature Stability Maximum [°C]
Commentary
Organism
37
-
thermolabil, significantly reduced activity after incubation at temperatures higher than 37°C for 30 min
Alphacoronavirus
Turnover Number [1/s] (protein specific)
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
0.023
-
Abz-FRLKGGAPIKGV-N-(2,4-dinitrophenyl)-ethylenediamine
at pH 5.25
Alphacoronavirus
0.025
-
FRLKGGAPIKGV
-
Alphacoronavirus
0.1
-
Abz-FRLKGGAPIKGV-N-(2,4-dinitrophenyl)-ethylenediamine
at pH 9.8
Alphacoronavirus
0.198
-
Abz-FRLKGGAPIKGV-N-(2,4-dinitrophenyl)-ethylenediamine
at pH 6.05
Alphacoronavirus
0.233
-
Abz-FRLKGGAPIKGV-N-(2,4-dinitrophenyl)-ethylenediamine
at pH 9.2
Alphacoronavirus
0.33
-
Abz-FRLKGGAPIKGV-N-(2,4-dinitrophenyl)-ethylenediamine
at pH 7.42
Alphacoronavirus
0.343
-
Abz-FRLKGGAPIKGV-N-(2,4-dinitrophenyl)-ethylenediamine
at pH 6.82
Alphacoronavirus
0.363
-
Abz-FRLKGGAPIKGV-N-(2,4-dinitrophenyl)-ethylenediamine
at pH 8.01
Alphacoronavirus
0.366
-
Abz-FRLKGGAPIKGV-N-(2,4-dinitrophenyl)-ethylenediamine
at pH 8.65
Alphacoronavirus
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
6.8
8.6
-
Alphacoronavirus
Other publictions for EC 3.4.22.B50
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Protein Variants
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Synonyms
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
kcat/KM [mM/s]
kcat/KM [mM/s] (protein specific)
752517
Chu
Porcine epidemic diarrhea vir ...
porcine epidemic diarrhea virus
Antiviral Res.
158
199-205
2018
-
-
1
1
1
-
2
4
-
-
1
-
-
1
-
-
-
-
-
-
-
-
3
1
-
-
-
-
4
-
-
-
-
1
-
2
-
-
1
-
1
1
-
2
2
1
4
-
-
1
-
-
-
-
-
-
-
-
-
3
1
-
-
-
4
-
-
-
-
-
-
-
-
4
4
731149
Baez-Santos
The SARS-coronavirus papain-li ...
Severe acute respiratory syndrome-related coronavirus
Antiviral Res.
115
21-38
2015
-
1
-
1
1
-
20
-
-
2
-
-
-
5
-
-
-
1
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
1
-
16
-
1
-
-
1
1
-
16
20
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
732186
Kong
Structural view and substrate ...
infectious bronchitis virus
J. Biol. Chem.
290
7160-7168
2015
-
-
1
1
-
-
-
2
-
-
-
1
-
1
-
-
1
-
-
-
-
-
4
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
2
-
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-
1
-
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-
1
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
754545
Mielech
Murine coronavirus ubiquitin- ...
Murine coronavirus
J. Virol.
89
4907-4917
2015
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
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-
-
-
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-
-
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-
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-
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-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
755638
van Kasteren
In vivo assessment of equine ...
equine arteritis virus, equine arteritis virus Bucyrus
Vet. Microbiol.
178
132-137
2015
-
1
-
-
1
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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-
1
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-
-
1
-
-
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-
-
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
731069
Chou
Structural basis for catalysis ...
Severe acute respiratory syndrome-related coronavirus
Acta Crystallogr. Sect. D
70
572-581
2014
-
-
1
1
9
-
3
9
-
-
-
-
-
3
-
-
1
-
-
-
-
-
2
-
3
1
-
-
8
1
-
-
-
2
-
-
-
-
1
-
1
9
-
-
3
2
9
-
-
-
-
-
-
-
1
-
-
-
-
2
-
1
-
-
8
1
-
-
-
-
3
3
-
8
8
732257
Xing
The papain-like protease of po ...
porcine epidemic diarrhea virus
J. Gen. Virol.
94
1554-1567
2013
-
-
1
-
3
-
-
-
-
-
-
3
-
1
-
-
-
-
-
-
-
-
3
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
3
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
732725
Dutta
Enhancement of proteolytic act ...
Tabernaemontana divaricata
PLoS ONE
8
e62619
2013
1
-
1
-
3
-
1
4
-
-
1
-
-
3
-
-
1
-
1
-
4
-
3
1
2
1
-
1
4
1
1
-
-
-
-
4
1
-
1
-
-
3
-
4
1
-
4
-
-
1
-
-
-
-
1
1
-
4
-
3
1
1
-
1
4
1
1
-
-
-
-
-
-
4
4
732827
van Kasteren
Deubiquitinase function of art ...
equine arteritis virus
Proc. Natl. Acad. Sci. USA
110
E838-E847
2013
-
-
1
1
4
-
1
-
-
-
-
1
-
1
-
-
1
-
-
-
-
-
3
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
4
-
-
1
-
-
-
-
-
1
-
-
-
1
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
2
2
-
6
6
718000
Chaudhuri
Comparison of SARS and NL63 pa ...
Human coronavirus NL63
J. Mol. Biol.
414
272-288
2011
-
1
-
-
-
-
-
-
-
-
-
3
-
1
-
-
-
-
-
-
-
-
3
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
718275
Wang
PLP2 of mouse hepatitis virus ...
Murine hepatitis virus
PLoS ONE
6
e17192
2011
-
-
1
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