BRENDA - Enzyme Database
show all sequences of 3.4.22.B14

Transmissible gastroenteritis virus papain-like protease 1 antagonizes production of interferon-beta through its deubiquitinase activity

Hu, X.; Tian, J.; Kang, H.; Guo, D.; Liu, J.; Liu, D.; Jiang, Q.; Li, Z.; Qu, J.; Qu, L.; BioMed Res. Int. 2017, 7089091 (2017) View publication on PubMedView publication on EuropePMC

Data extracted from this reference:

Engineering
Protein Variants
Commentary
Organism
C32A
mutant is unable to degrade ubiquitinated protein
Transmissible gastroenteritis virus
D196A
mutant is unable to degrade ubiquitinated protein
Transmissible gastroenteritis virus
H183A
mutant is unable to degrade ubiquitinated protein
Transmissible gastroenteritis virus
Organism
Organism
UniProt
Commentary
Textmining
Transmissible gastroenteritis virus
-
-
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
ubiquitinated RIG-I + H2O
substrate is a key fegulator in the IFN signaling pathway
752911
Transmissible gastroenteritis virus
ubiquitin + RIG-I
-
-
-
?
ubiquitinated STING + H2O
substrate is a key fegulator in the IFN signaling pathway
752911
Transmissible gastroenteritis virus
ubiquitin + STINGI
-
-
-
?
Synonyms
Synonyms
Commentary
Organism
PL1
-
Transmissible gastroenteritis virus
Engineering (protein specific)
Protein Variants
Commentary
Organism
C32A
mutant is unable to degrade ubiquitinated protein
Transmissible gastroenteritis virus
D196A
mutant is unable to degrade ubiquitinated protein
Transmissible gastroenteritis virus
H183A
mutant is unable to degrade ubiquitinated protein
Transmissible gastroenteritis virus
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
ubiquitinated RIG-I + H2O
substrate is a key fegulator in the IFN signaling pathway
752911
Transmissible gastroenteritis virus
ubiquitin + RIG-I
-
-
-
?
ubiquitinated STING + H2O
substrate is a key fegulator in the IFN signaling pathway
752911
Transmissible gastroenteritis virus
ubiquitin + STINGI
-
-
-
?
General Information
General Information
Commentary
Organism
physiological function
PL1 can suppress the IFN-beta expression and inhibit the nuclear translocation of interferon regulatory factor 3.The ability to antagonize IFN-beta production is dependent on the intact catalytic activity of PL1. PL1 exerts deubiquitinase activity which strongly inhibits the retinoic acid-induced gene I- and stimulator of interferon gene-dependent IFN expression
Transmissible gastroenteritis virus
General Information (protein specific)
General Information
Commentary
Organism
physiological function
PL1 can suppress the IFN-beta expression and inhibit the nuclear translocation of interferon regulatory factor 3.The ability to antagonize IFN-beta production is dependent on the intact catalytic activity of PL1. PL1 exerts deubiquitinase activity which strongly inhibits the retinoic acid-induced gene I- and stimulator of interferon gene-dependent IFN expression
Transmissible gastroenteritis virus
Other publictions for EC 3.4.22.B14
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Synonyms
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
755215
Niemeyer
The papain-like protease dete ...
SARS coronavirus FRA
PLoS Pathog.
14
e1007296
2018
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
752911
Hu
Transmissible gastroenteritis ...
Transmissible gastroenteritis virus
BioMed Res. Int.
2017
7089091
2017
-
-
-
-
3
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
754425
Daczkowski
Structural insights into the ...
Severe acute respiratory syndrome-related coronavirus
J. Mol. Biol.
429
1661-1683
2017
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
755428
Li
SARS coronavirus papain-like ...
Severe acute respiratory syndrome-related coronavirus
Sci. Rep.
6
25754
2016
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
752708
Bekes
SARS hCoV papain-like proteas ...
Severe acute respiratory syndrome-related coronavirus, Middle East respiratory syndrome-related coronavirus
Biochem. J.
468
215-226
2015
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
8
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
8
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
754125
Kong
Structural view and substrate ...
infectious bronchitis virus, infectious bronchitis virus Beaudette
J. Biol. Chem.
290
7160-7168
2015
-
-
1
1
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
11
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
11
-
-
-
-
-
-
-
-
-
-
-
-
-
2
2
709746
Wojdyla
Papain-like protease 1 from tr ...
Transmissible gastroenteritis virus, Transmissible gastroenteritis virus Purdue
J. Virol.
84
10063-10073
2010
-
-
1
1
-
-
-
-
-
-
-
-
-
3
-
-
1
-
-
-
-
-
8
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
8
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
709752
Gadlage
Exchange of the coronavirus re ...
Murine hepatitis virus
J. Virol.
84
6894-6898
2010
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
3
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
709449
Ghosh
Structure-based design, synthe ...
Severe acute respiratory syndrome-related coronavirus
J. Med. Chem.
52
5228-5240
2009
-
-
1
-
-
-
22
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
21
-
-
1
-
-
-
-
21
22
-
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
670849
Sulea
Binding site-based classificat ...
Murine hepatitis virus, Transmissible gastroenteritis virus, infectious bronchitis virus, bovine coronavirus, Human coronavirus 229E, Severe acute respiratory syndrome-related coronavirus, porcine epidemic diarrhea virus, Murine hepatitis virus A59, bovine coronavirus Ent, infectious bronchitis virus Beaudette
Proteins Struct. Funct. Bioinform.
62
760-775
2006
-
-
-
-
-
-
-
-
-
-
-
-
-
14
-
-
-
-
-
-
-
-
-
-
7
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
681672
Graham
Replication of murine hepatiti ...
Murine hepatitis virus
J. Virol.
80
11610-11620
2006
-
-
-
-
-
-
-
-
-
-
-
-
-
6
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
668774
Kanjanahaluethai
-
Coronavirus papain-like endope ...
Murine hepatitis virus
Handbook of Proteolytic Enzymes (Barrett, A. J. , Rawlings, N. D. , Woessner, J. F. , eds. )Academic Press
2
1265-1269
2004
-
-
1
-
-
-
3
-
-
-
1
2
-
1
-
-
1
-
-
-
-
-
2
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
3
-
-
-
-
1
2
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
670071
Harcourt
Identification of severe acute ...
Severe acute respiratory syndrome-related coronavirus, Severe acute respiratory syndrome-related coronavirus Urbani
J. Virol.
78
13600-13612
2004
-
-
1
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
2
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
647411
Teng
Further in vitro characterizat ...
Murine coronavirus, Murine coronavirus JHM
J. Neurovirol.
8
143-149
2002
-
-
-
-
-
-
-
-
-
-
-
2
-
14
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
647410
Teng
Expression of murine coronavir ...
Murine coronavirus, Murine coronavirus JHM
J. Virol.
73
2658-2666
1999
-
-
1
-
-
-
-
-
-
-
-
2
-
9
-
-
1
-
-
-
-
-
6
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
1
-
-
-
-
6
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
647412
Bonilla
Characterization of the leader ...
Murine coronavirus, Murine coronavirus JHM
Virology
209
489-497
1995
-
-
1
-
-
-
-
-
-
-
-
2
-
8
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-