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Literature summary for 3.4.22.69 extracted from

  • Wang, L.; Bao, B.B.; Song, G.Q.; Chen, C.; Zhang, X.M.; Lu, W.; Wang, Z.; Cai, Y.; Li, S.; Fu, S.; Song, F.H.; Yang, H.; Wang, J.G.
    Discovery of unsymmetrical aromatic disulfides as novel inhibitors of SARS-CoV main protease Chemical synthesis, biological evaluation, molecular docking and 3D-QSAR study (2017), Eur. J. Med. Chem., 137, 450-461 .
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
2-[(4-chlorophenyl)disulfanyl]-1,3,4-oxadiazole reversible inhibition Severe acute respiratory syndrome-related coronavirus
2-[(4-chlorophenyl)disulfanyl]pyrimidine reversible inhibition Severe acute respiratory syndrome-related coronavirus

Organism

Organism UniProt Comment Textmining
Severe acute respiratory syndrome-related coronavirus P0C6X7 human, i.e. SARS-CoV
-

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000516
-
pH 7.3, 37°C Severe acute respiratory syndrome-related coronavirus 2-[(4-chlorophenyl)disulfanyl]-1,3,4-oxadiazole
0.000684
-
pH 7.3, 37°C Severe acute respiratory syndrome-related coronavirus 2-[(4-chlorophenyl)disulfanyl]pyrimidine