Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(2E)-1-[3-(2-hydroperoxy-3-methylbut-3-en-1-yl)-2-hydroxy-4-methoxyphenyl]-3-(4-hydroxyphenyl)prop-2-en-1-one | - |
Severe acute respiratory syndrome-related coronavirus | |
(4E)-1,7-bis(3,4-dihydroxyphenyl)hept-4-en-3-one | - |
Severe acute respiratory syndrome-related coronavirus | |
5-(4-methylpiperidine-1-sulfonyl)-1-phenyl-1H-indole-2,3-dione | - |
Severe acute respiratory syndrome-related coronavirus | |
5-(4-methylpiperidine-1-sulfonyl)-1H-indole-2,3-dione | - |
Severe acute respiratory syndrome-related coronavirus | |
Nalpha-[(2E)-3-(4-chloro-2-fluorophenyl)prop-2-enoyl]-N-[(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl]-D-phenylalaninamide | - |
Severe acute respiratory syndrome-related coronavirus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Severe acute respiratory syndrome-related coronavirus | P0C6X7 | human, i.e. SARS-CoV | - |
Synonyms | Comment | Organism |
---|---|---|
3C-like peptidase | - |
Severe acute respiratory syndrome-related coronavirus |
3cLpro | - |
Severe acute respiratory syndrome-related coronavirus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0002 | - |
pH and temperature not specified in the publication | Severe acute respiratory syndrome-related coronavirus | Nalpha-[(2E)-3-(4-chloro-2-fluorophenyl)prop-2-enoyl]-N-[(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl]-D-phenylalaninamide | |
0.00104 | - |
pH and temperature not specified in the publication | Severe acute respiratory syndrome-related coronavirus | 5-(4-methylpiperidine-1-sulfonyl)-1-phenyl-1H-indole-2,3-dione | |
0.00118 | - |
pH and temperature not specified in the publication | Severe acute respiratory syndrome-related coronavirus | 5-(4-methylpiperidine-1-sulfonyl)-1H-indole-2,3-dione | |
0.0071 | - |
pH and temperature not specified in the publication | Severe acute respiratory syndrome-related coronavirus | (2E)-1-[3-(2-hydroperoxy-3-methylbut-3-en-1-yl)-2-hydroxy-4-methoxyphenyl]-3-(4-hydroxyphenyl)prop-2-en-1-one | |
0.0362 | - |
pH and temperature not specified in the publication | Severe acute respiratory syndrome-related coronavirus | (4E)-1,7-bis(3,4-dihydroxyphenyl)hept-4-en-3-one |
General Information | Comment | Organism |
---|---|---|
physiological function | the protease 3CLpro processes the polypeptide translation product from the genomic RNA into the structural and nonstructural protein components vital for the replication and packaging of a new generation of viruses | Severe acute respiratory syndrome-related coronavirus |