Protein Variants | Comment | Organism |
---|---|---|
R188I | auto-proteolysis resistant mutant | Severe acute respiratory syndrome-related coronavirus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(R)-N-(E)-3',4',5'-trimethoxy-3-phenylprop-2-enoicserine(benzoyl)cyclohexylamide | IC50 value 0.5 mM for cathepsin B, not cytotoxic | Severe acute respiratory syndrome-related coronavirus | |
(R)-N-cinnamoyl serine(benzoyl)cyclohexylamide | not inhibitory to cathepsin B at 1 mM, not cytotoxic | Severe acute respiratory syndrome-related coronavirus | |
1,6-di(propan-2-yl)-N-(4-[[4-(prop-2-en-1-yl)-5-sulfanylidene-4,5-dihydro-1H-1,2,4-triazol-3-yl]methyl]-1,3-thiazol-2-yl)-1H-pyrazolo[3,4-b]pyridine-4-carboxamide | - |
Severe acute respiratory syndrome-related coronavirus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Severe acute respiratory syndrome-related coronavirus | P0C6X7 | human, i.e. SARS-CoV | - |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.03 | - |
pH 4.0, temperature not specified in the publication | Severe acute respiratory syndrome-related coronavirus | (R)-N-cinnamoyl serine(benzoyl)cyclohexylamide | |
0.043 | - |
mutant R188I, pH not specified in the publication, temperature not specified in the publication | Severe acute respiratory syndrome-related coronavirus | 1,6-di(propan-2-yl)-N-(4-[[4-(prop-2-en-1-yl)-5-sulfanylidene-4,5-dihydro-1H-1,2,4-triazol-3-yl]methyl]-1,3-thiazol-2-yl)-1H-pyrazolo[3,4-b]pyridine-4-carboxamide | |
0.065 | - |
pH 4.0, temperature not specified in the publication | Severe acute respiratory syndrome-related coronavirus | (R)-N-(E)-3',4',5'-trimethoxy-3-phenylprop-2-enoicserine(benzoyl)cyclohexylamide |