Literature summary for 3.4.22.69 extracted from

Yang, Q.; Chen, L.; He, X.; Gao, Z.; Shen, X.; Bai, D.
Design and synthesis of cinanserin analogs as severe acute respiratory syndrome coronavirus 3CL protease inhibitors (2008), Chem. Pharm. Bull., 56, 1400-1405.

Search for more literature for 3.4.22.69

Inhibitors

Inhibitors	Comment	Organism	Structure
cinanserin	-	Severe acute respiratory syndrome-related coronavirus
N-(2-allylthiophenyl)cinnamide	-	Severe acute respiratory syndrome-related coronavirus
N-(2-benzylthiophenyl)cinnamide	-	Severe acute respiratory syndrome-related coronavirus
N-(2-carbomethoxyethylthiophenyl)cinnamide	-	Severe acute respiratory syndrome-related coronavirus
N-(2-cinnamoylthiophenyl)cinnamide	-	Severe acute respiratory syndrome-related coronavirus
N-[2-(2-cyanocinnamoylthio)phenyl]-2-cyanocinnamide	-	Severe acute respiratory syndrome-related coronavirus
N-[2-(2-pyridylmethylthio)phenyl]cinnamide	-	Severe acute respiratory syndrome-related coronavirus
N-[2-(3-dimethylaminopropylthio)phenyl]-2-cyanocinnamide	-	Severe acute respiratory syndrome-related coronavirus
N-[2-(3-pyridylmethylthio)phenyl]cinnamide	-	Severe acute respiratory syndrome-related coronavirus

Organism

Organism	UniProt	Comment	Textmining
Severe acute respiratory syndrome-related coronavirus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
Dabcyl-KNSTLQSGLRKE-EDANS + H2O	-	Severe acute respiratory syndrome-related coronavirus	Dabcyl-KNSTLQ + SGLRKE-EDANS	-	?

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.00106	-	-	Severe acute respiratory syndrome-related coronavirus	N-(2-cinnamoylthiophenyl)cinnamide
0.0135	-	-	Severe acute respiratory syndrome-related coronavirus	N-(2-carbomethoxyethylthiophenyl)cinnamide
0.0197	-	-	Severe acute respiratory syndrome-related coronavirus	N-(2-allylthiophenyl)cinnamide
0.0437	-	-	Severe acute respiratory syndrome-related coronavirus	N-[2-(2-cyanocinnamoylthio)phenyl]-2-cyanocinnamide
0.125	-	-	Severe acute respiratory syndrome-related coronavirus	N-[2-(3-dimethylaminopropylthio)phenyl]-2-cyanocinnamide
0.206	-	-	Severe acute respiratory syndrome-related coronavirus	N-(2-benzylthiophenyl)cinnamide
0.293	-	-	Severe acute respiratory syndrome-related coronavirus	N-[2-(2-pyridylmethylthio)phenyl]cinnamide
0.323	-	-	Severe acute respiratory syndrome-related coronavirus	cinanserin
0.347	-	-	Severe acute respiratory syndrome-related coronavirus	N-[2-(3-pyridylmethylthio)phenyl]cinnamide

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Release 2023.1 (January 2023)