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Literature summary for 3.4.22.69 extracted from

  • Wen, C.; Kuo, Y.; Jan, J.; Liang, P.; Wang, S.; Liu, H.; Lee, C.; Chang, S.; Kuo, C.; Lee, S.; Hou, C.; Hsiao, P.; Chien, S.; Shyur, L.; Yang, N.
    Specific plant terpenoids and lignoids possess potent antiviral activities against severe acute respiratory syndrome coronavirus (2007), J. Med. Chem., 50, 4087-4095.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
betulinic acid competitive Severe acute respiratory syndrome-related coronavirus
curcumin
-
Severe acute respiratory syndrome-related coronavirus
niclosamide
-
Severe acute respiratory syndrome-related coronavirus
savinin competitive Severe acute respiratory syndrome-related coronavirus

Organism

Organism UniProt Comment Textmining
Severe acute respiratory syndrome-related coronavirus
-
-
-

Synonyms

Synonyms Comment Organism
SARS-CoV 3CL protease
-
Severe acute respiratory syndrome-related coronavirus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0082
-
betulinic acid
-
Severe acute respiratory syndrome-related coronavirus
0.0091
-
savinin
-
Severe acute respiratory syndrome-related coronavirus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.01
-
-
Severe acute respiratory syndrome-related coronavirus betulinic acid
0.025
-
-
Severe acute respiratory syndrome-related coronavirus savinin
0.04
-
-
Severe acute respiratory syndrome-related coronavirus curcumin
0.04
-
-
Severe acute respiratory syndrome-related coronavirus niclosamide