Crystallization (Comment) | Organism |
---|---|
- |
Severe acute respiratory syndrome-related coronavirus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1,1'-sulfonylbis(4-nitrobenzene) | - |
Severe acute respiratory syndrome-related coronavirus | |
1-[(4-chlorophenyl)sulfonyl]-2-nitro-4-(trifluoromethyl)benzene | - |
Severe acute respiratory syndrome-related coronavirus | |
2',5'-dimethyl-3-(methylthio)-4'-nitro-5-(2-thienyl)-2'H-1,3'-bipyrazole-4-carbonitrile | - |
Severe acute respiratory syndrome-related coronavirus | |
2,4-dichloro-5-methylphenyl 2,6-dinitro-4-(trifluoromethyl)phenyl sulfone | - |
Severe acute respiratory syndrome-related coronavirus | |
2-(4,5-dihydro-1,3-thiazol-2-yl)-1-(1,3-thiazol-2-yl)ethanone | - |
Severe acute respiratory syndrome-related coronavirus | |
2-[(2-acetylphenyl)sulfonyl]benzoic acid | - |
Severe acute respiratory syndrome-related coronavirus | |
2-[(4-chlorophenyl)sulfonyl]-5-nitropyridine 1-oxide | - |
Severe acute respiratory syndrome-related coronavirus | |
3-[(2-furylmethyl)amino]-6,6-dimethyl-4-oxo-4,5,6,7-tetrahydro-2-benzothiophene-1-carbonitrile | - |
Severe acute respiratory syndrome-related coronavirus | |
4,6-dimethyl-2-[(4-methylphenyl)sulfonyl]-5-nitronicotinonitrile | - |
Severe acute respiratory syndrome-related coronavirus | |
4,6-dimethyl-5-nitro-2-(phenylsulfonyl)nicotinonitrile | - |
Severe acute respiratory syndrome-related coronavirus | |
4-(5-chloro-2-thienyl)-2-[(2-thienylsulfonyl)methyl]-1,3-thiazole | - |
Severe acute respiratory syndrome-related coronavirus | |
4-[(3,5-dibromo-4-hydroxyphenyl)sulfonyl]benzoic acid | - |
Severe acute respiratory syndrome-related coronavirus | |
5-(1,3-dimethyl-1H-pyrazol-5-yl)-N-(3-methyl-4-nitroisoxazol-5-yl)thiophene-2-carboxamide | - |
Severe acute respiratory syndrome-related coronavirus | |
5-[(4-chlorophenyl)sulfonyl]pyrimidine-2,4-diamine | - |
Severe acute respiratory syndrome-related coronavirus | |
diethyl (2E,2'E)-3,3'-[sulfonylbis(benzene-4,1-diylimino)]bis(2-cyanoprop-2-enoate) | - |
Severe acute respiratory syndrome-related coronavirus | |
N-(2,2'-bithien-5-ylmethyl)-1,3-dimethyl-4-nitro-1H-pyrazol-5-amine | - |
Severe acute respiratory syndrome-related coronavirus | |
N-[3-(5-tert-butyl-2-methyl-3-furyl)-1H-pyrazol-5-yl]thiophene-2-sulfonamide | - |
Severe acute respiratory syndrome-related coronavirus | |
N-[4-[(4-chlorophenyl)sulfonyl]-3-(methylthio)-1H-pyrazol-5-yl]thiophene-2-carboxamide | - |
Severe acute respiratory syndrome-related coronavirus | |
S-[5-(trichloromethyl)-4H-1,2,4-triazol-3-yl] 5-(phenylethynyl)furan-2-carbothioate | - |
Severe acute respiratory syndrome-related coronavirus | |
sulfonyldi-4,1-phenylene bis(2,3,3-trichloroacrylate) | - |
Severe acute respiratory syndrome-related coronavirus | |
tetraethyl 2,2'-[sulfonylbis(benzene-4,1-diyliminomethylylidene)]dipropanedioate | - |
Severe acute respiratory syndrome-related coronavirus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Severe acute respiratory syndrome-related coronavirus | - |
- |
- |
Purification (Comment) | Organism |
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- |
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Synonyms | Comment | Organism |
---|---|---|
SARS-CoV main protease | - |
Severe acute respiratory syndrome-related coronavirus |
SARS-CoV Mpro | - |
Severe acute respiratory syndrome-related coronavirus |
severe acute respiratory syndrome coronavirus main protease | - |
Severe acute respiratory syndrome-related coronavirus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0003 | - |
- |
Severe acute respiratory syndrome-related coronavirus | 2,4-dichloro-5-methylphenyl 2,6-dinitro-4-(trifluoromethyl)phenyl sulfone | |
0.0009 | - |
- |
Severe acute respiratory syndrome-related coronavirus | sulfonyldi-4,1-phenylene bis(2,3,3-trichloroacrylate) | |
0.003 | - |
- |
Severe acute respiratory syndrome-related coronavirus | S-[5-(trichloromethyl)-4H-1,2,4-triazol-3-yl] 5-(phenylethynyl)furan-2-carbothioate | |
0.005 | - |
- |
Severe acute respiratory syndrome-related coronavirus | 5-(1,3-dimethyl-1H-pyrazol-5-yl)-N-(3-methyl-4-nitroisoxazol-5-yl)thiophene-2-carboxamide | |
0.006 | - |
- |
Severe acute respiratory syndrome-related coronavirus | 5-[(4-chlorophenyl)sulfonyl]pyrimidine-2,4-diamine | |
0.01 | - |
- |
Severe acute respiratory syndrome-related coronavirus | N-[3-(5-tert-butyl-2-methyl-3-furyl)-1H-pyrazol-5-yl]thiophene-2-sulfonamide | |
0.012 | - |
- |
Severe acute respiratory syndrome-related coronavirus | 1-[(4-chlorophenyl)sulfonyl]-2-nitro-4-(trifluoromethyl)benzene | |
0.013 | - |
- |
Severe acute respiratory syndrome-related coronavirus | 4,6-dimethyl-2-[(4-methylphenyl)sulfonyl]-5-nitronicotinonitrile | |
0.013 | - |
- |
Severe acute respiratory syndrome-related coronavirus | 4,6-dimethyl-5-nitro-2-(phenylsulfonyl)nicotinonitrile | |
0.015 | - |
- |
Severe acute respiratory syndrome-related coronavirus | 2-[(4-chlorophenyl)sulfonyl]-5-nitropyridine 1-oxide | |
0.015 | - |
- |
Severe acute respiratory syndrome-related coronavirus | N-[4-[(4-chlorophenyl)sulfonyl]-3-(methylthio)-1H-pyrazol-5-yl]thiophene-2-carboxamide | |
0.016 | - |
- |
Severe acute respiratory syndrome-related coronavirus | 2-[(2-acetylphenyl)sulfonyl]benzoic acid | |
0.016 | - |
- |
Severe acute respiratory syndrome-related coronavirus | 3-[(2-furylmethyl)amino]-6,6-dimethyl-4-oxo-4,5,6,7-tetrahydro-2-benzothiophene-1-carbonitrile | |
0.016 | - |
- |
Severe acute respiratory syndrome-related coronavirus | 4-[(3,5-dibromo-4-hydroxyphenyl)sulfonyl]benzoic acid | |
0.016 | - |
- |
Severe acute respiratory syndrome-related coronavirus | diethyl (2E,2'E)-3,3'-[sulfonylbis(benzene-4,1-diylimino)]bis(2-cyanoprop-2-enoate) | |
0.018 | - |
- |
Severe acute respiratory syndrome-related coronavirus | 2',5'-dimethyl-3-(methylthio)-4'-nitro-5-(2-thienyl)-2'H-1,3'-bipyrazole-4-carbonitrile | |
0.018 | - |
- |
Severe acute respiratory syndrome-related coronavirus | 4-(5-chloro-2-thienyl)-2-[(2-thienylsulfonyl)methyl]-1,3-thiazole | |
0.02 | - |
- |
Severe acute respiratory syndrome-related coronavirus | N-(2,2'-bithien-5-ylmethyl)-1,3-dimethyl-4-nitro-1H-pyrazol-5-amine | |
0.025 | - |
- |
Severe acute respiratory syndrome-related coronavirus | 1,1'-sulfonylbis(4-nitrobenzene) | |
0.032 | - |
- |
Severe acute respiratory syndrome-related coronavirus | tetraethyl 2,2'-[sulfonylbis(benzene-4,1-diyliminomethylylidene)]dipropanedioate | |
0.04 | - |
- |
Severe acute respiratory syndrome-related coronavirus | 2-(4,5-dihydro-1,3-thiazol-2-yl)-1-(1,3-thiazol-2-yl)ethanone |