Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(S)-2-((2S,3R)-2-((S)-2-acetamido-3-methylbutanamido)-3-(benzyloxy)butanamido)-4-methyl-N-((S)-4-(5-nitro-1,4-dioxo-3,4-dihydrophthalazin-2(1H)-yl)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl)pentanamide | - |
Severe acute respiratory syndrome-related coronavirus | |
1-(1-benzothiophen-2-ylmethyl)-5-iodo-1H-indole-2,3-dione | - |
Severe acute respiratory syndrome-related coronavirus | |
1-(2-naphthylmethyl)-2,3-dioxoindoline-5-carboxamide | - |
Severe acute respiratory syndrome-related coronavirus | |
1-[bis(4-chlorophenyl)methyl]-3-[2-[(2,4-dichlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazol-3-ium | - |
Severe acute respiratory syndrome-related coronavirus | |
2-(4-aminophenyl)-6-methyl-1H-benzimidazole-7-sulfonic acid | - |
Severe acute respiratory syndrome-related coronavirus | |
2-([N-[(benzyloxy)carbonyl]-L-alanyl-L-valyl]amino)-5-[[(2S,5S)-5-[[(benzyloxy)carbonyl]amino]-2-(1-methylethyl)-4-oxohexanoyl]amino]-1,2,5,6-tetradeoxy-1,6-diphenyl-L-iditol | - |
Severe acute respiratory syndrome-related coronavirus | |
2-phenylethyl 2-methyl-4-(2-nitrophenyl)-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate | - |
Severe acute respiratory syndrome-related coronavirus | |
3,4-dichloro-5-[2-(5-chloro-3-methyl-1-benzothien-2-yl)-2-oxoethyl]furan-2(5H)-one | - |
Severe acute respiratory syndrome-related coronavirus | |
5-chloropyridin-3-yl thiophene-2-carboxylate | - |
Severe acute respiratory syndrome-related coronavirus | |
bis[1,3]thiazolo[4,5-b:5',4'-e]pyridine-2,6-diamine | - |
Severe acute respiratory syndrome-related coronavirus | |
cinanserin | - |
Severe acute respiratory syndrome-related coronavirus | |
Hexachlorophene | - |
Severe acute respiratory syndrome-related coronavirus | |
methyl 4-hydroxy-6-(trifluoromethyl)furo[2,3-b]pyridine-2-carboxylate | - |
Severe acute respiratory syndrome-related coronavirus | |
N-(2-chloro-4-nitrophenyl)-Nalpha-[[4-(dimethylamino)phenyl]carbonyl]phenylalaninamide | - |
Severe acute respiratory syndrome-related coronavirus | |
[benzene-1,4-diylbis[carbamoyl(5-nitrobenzene-3,1-diyl)]]diboronic acid | - |
Severe acute respiratory syndrome-related coronavirus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Severe acute respiratory syndrome-related coronavirus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
AAVLQSGF-NH2 + H2O | - |
Severe acute respiratory syndrome-related coronavirus | AAVLQ + SGF-NH2 | - |
? | |
ATVRLQAGNAT + H2O | - |
Severe acute respiratory syndrome-related coronavirus | ATVRLQ + AGNAT | - |
? | |
AVLQS-NH2 + H2O | - |
Severe acute respiratory syndrome-related coronavirus | AVLQ + L-serinamide | - |
? | |
AVLQSE-NH2 + H2O | - |
Severe acute respiratory syndrome-related coronavirus | AVLQ + Ser-Glu-NH2 | - |
? | |
AVLQSGF-NH2 + H2O | - |
Severe acute respiratory syndrome-related coronavirus | AVLQ + SGF-NH2 | - |
? | |
FYPKLQASQAW + H2O | - |
Severe acute respiratory syndrome-related coronavirus | FYPKLQ + ASQAW | - |
? | |
KVATVQSKMSD + H2O | - |
Severe acute respiratory syndrome-related coronavirus | KVATVQ + SKMSD | - |
? | |
LAVLQSGF-NH2 + H2O | - |
Severe acute respiratory syndrome-related coronavirus | LAVLQ + SGF-NH2 | - |
? | |
LQSG-NH2 + H2O | - |
Severe acute respiratory syndrome-related coronavirus | Leu-Gln + Ser-Gly-NH2 | - |
? | |
NRATLQAIASE + H2O | - |
Severe acute respiratory syndrome-related coronavirus | NRATLQ + AIASE | - |
? | |
NVATLQAENVT + H2O | - |
Severe acute respiratory syndrome-related coronavirus | NVATLQ + AENVT | - |
? | |
PATVLQAVGAC + H2O | - |
Severe acute respiratory syndrome-related coronavirus | PATVLQ + AVGAC | - |
? | |
REPLMQSADAS + H2O | - |
Severe acute respiratory syndrome-related coronavirus | REPLMQ + SADAS | - |
? | |
SAALQSGF-NH2 + H2O | - |
Severe acute respiratory syndrome-related coronavirus | SAALQ + SGF-NH2 | - |
? | |
SAKLQSGF-NH2 + H2O | - |
Severe acute respiratory syndrome-related coronavirus | SAKLQ + SGF-NH2 | - |
? | |
SALLQSGF-NH2 + H2O | - |
Severe acute respiratory syndrome-related coronavirus | SALLQ + SGF-NH2 | - |
? | |
SATLQSGF-NH2 + H2O | - |
Severe acute respiratory syndrome-related coronavirus | SATLQ + SGF-NH2 | - |
? | |
SAVAQSGF-NH2 + H2O | - |
Severe acute respiratory syndrome-related coronavirus | SAVAQ + SGF-NH2 | - |
? | |
SAVFQSGF-NH2 + H2O | - |
Severe acute respiratory syndrome-related coronavirus | SAVMQ + SGF-NH2 | - |
? | |
SAVIQSGF-NH2 + H2O | - |
Severe acute respiratory syndrome-related coronavirus | SAVIQ + SGF-NH2 | - |
? | |
SAVKLQNNELS + H2O | - |
Severe acute respiratory syndrome-related coronavirus | SAVKLQ + NNELS | - |
? | |
SAVLESGF-NH2 + H2O | - |
Severe acute respiratory syndrome-related coronavirus | SAVLE + SGF-NH2 | - |
? | |
SAVLKSGF-NH2 + H2O | - |
Severe acute respiratory syndrome-related coronavirus | SAVLK + SGF-NH2 | - |
? | |
SAVLNSGF-NH2 + H2O | - |
Severe acute respiratory syndrome-related coronavirus | SAVLN + SGF-NH | - |
? | |
SAVLQAGF-NH2 + H2O | - |
Severe acute respiratory syndrome-related coronavirus | SAVLQ + AGF-NH2 | - |
? | |
SAVLQGGF-NH2 + H2O | - |
Severe acute respiratory syndrome-related coronavirus | SAVLQ + GGF-NH2 | - |
? | |
SAVLQLGF-NH2 + H2O | - |
Severe acute respiratory syndrome-related coronavirus | SAVLQ + LGF-NH2 | - |
? | |
SAVLQSGF-NH2 + H2O | - |
Severe acute respiratory syndrome-related coronavirus | SAVLQ + SGF-NH2 | - |
? | |
SAVMQSGF-NH2 + H2O | - |
Severe acute respiratory syndrome-related coronavirus | SAVMQ + SGF-NH2 | - |
? | |
SAVRQSGF-NH2 + H2O | - |
Severe acute respiratory syndrome-related coronavirus | SAVRQ + SGF-NH2 | - |
? | |
SAVVQSGF-NH2 + H2O | - |
Severe acute respiratory syndrome-related coronavirus | SAVVQ + SGF-NH2 | - |
? | |
SGVTFQGKFKK + H2O | - |
Severe acute respiratory syndrome-related coronavirus | SGVTFQ + GKFKK | - |
? | |
SLVLQSGF-NH2 + H2O | - |
Severe acute respiratory syndrome-related coronavirus | SLVLQ + SGF-NH2 | - |
? | |
STVLQSGF-NH2 + H2O | - |
Severe acute respiratory syndrome-related coronavirus | STVLQ + SGF-NH2 | - |
? | |
SVVLQSGF-NH2 + H2O | - |
Severe acute respiratory syndrome-related coronavirus | SVVLQ + SGF-NH2 | - |
? | |
TAVLQSGF-NH2 + H2O | - |
Severe acute respiratory syndrome-related coronavirus | TAVLQ + SGF-NH2 | - |
? | |
TFTRLQSLENV + H2O | - |
Severe acute respiratory syndrome-related coronavirus | TFTRLQ + SLENV | - |
? | |
TSAVLQSGFRK-NH2 + H2O | - |
Severe acute respiratory syndrome-related coronavirus | TSAVLQ + SGFRK-NH2 | - |
? | |
TVKLQAGF-NH2 + H2O | - |
Severe acute respiratory syndrome-related coronavirus | TVKLQ + AGF-NH2 | - |
? | |
TVTLQSGF-NH2 + H2O | - |
Severe acute respiratory syndrome-related coronavirus | TVTLQ + SGF-NH2 | - |
? | |
TVVLQSGF-NH2 + H2O | - |
Severe acute respiratory syndrome-related coronavirus | TVVLQ + SGF-NH2 | - |
? | |
VLQS-NH2 + H2O | - |
Severe acute respiratory syndrome-related coronavirus | VLQ + L-serinamide | - |
? | |
VLQSG-NH2 + H2O | - |
Severe acute respiratory syndrome-related coronavirus | VLQ + Ser-Gly-NH2 | - |
? | |
VVTLQSGF-NH2 + H2O | - |
Severe acute respiratory syndrome-related coronavirus | VVTLQ + SGF-NH2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
SARS 3C-like proteinase | - |
Severe acute respiratory syndrome-related coronavirus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
wild-type enzyme | Severe acute respiratory syndrome-related coronavirus |
7.6 | - |
mutant enzyme C145S | Severe acute respiratory syndrome-related coronavirus |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
6.3 | 9.3 | pH 6.3: about 55% of maximal activity, pH 9.3: about 45% of maximal activity, mutant enzyme C145S | Severe acute respiratory syndrome-related coronavirus |
6.3 | 8.7 | pH 6.3: about 55% of maximal activity, pH 8.7: about 45% of maximal activity, wild-type enzyme | Severe acute respiratory syndrome-related coronavirus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00003 | - |
N-(2-chloro-4-nitrophenyl)-Nalpha-[[4-(dimethylamino)phenyl]carbonyl]phenylalaninamide | - |
Severe acute respiratory syndrome-related coronavirus | |
0.00004 | - |
[benzene-1,4-diylbis[carbamoyl(5-nitrobenzene-3,1-diyl)]]diboronic acid | - |
Severe acute respiratory syndrome-related coronavirus | |
0.0006 | - |
2-([N-[(benzyloxy)carbonyl]-L-alanyl-L-valyl]amino)-5-[[(2S,5S)-5-[[(benzyloxy)carbonyl]amino]-2-(1-methylethyl)-4-oxohexanoyl]amino]-1,2,5,6-tetradeoxy-1,6-diphenyl-L-iditol | - |
Severe acute respiratory syndrome-related coronavirus | |
0.0137 | - |
Hexachlorophene | - |
Severe acute respiratory syndrome-related coronavirus | |
0.061 | - |
1-[bis(4-chlorophenyl)methyl]-3-[2-[(2,4-dichlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazol-3-ium | - |
Severe acute respiratory syndrome-related coronavirus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00006 | - |
- |
Severe acute respiratory syndrome-related coronavirus | N-(2-chloro-4-nitrophenyl)-Nalpha-[[4-(dimethylamino)phenyl]carbonyl]phenylalaninamide | |
0.00037 | - |
- |
Severe acute respiratory syndrome-related coronavirus | 1-(2-naphthylmethyl)-2,3-dioxoindoline-5-carboxamide | |
0.0005 | - |
- |
Severe acute respiratory syndrome-related coronavirus | 5-chloropyridin-3-yl thiophene-2-carboxylate | |
0.0006 | - |
- |
Severe acute respiratory syndrome-related coronavirus | (S)-2-((2S,3R)-2-((S)-2-acetamido-3-methylbutanamido)-3-(benzyloxy)butanamido)-4-methyl-N-((S)-4-(5-nitro-1,4-dioxo-3,4-dihydrophthalazin-2(1H)-yl)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl)pentanamide | |
0.00095 | - |
- |
Severe acute respiratory syndrome-related coronavirus | 1-(1-benzothiophen-2-ylmethyl)-5-iodo-1H-indole-2,3-dione | |
0.0025 | - |
- |
Severe acute respiratory syndrome-related coronavirus | 2-phenylethyl 2-methyl-4-(2-nitrophenyl)-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate | |
0.0026 | - |
- |
Severe acute respiratory syndrome-related coronavirus | bis[1,3]thiazolo[4,5-b:5',4'-e]pyridine-2,6-diamine | |
0.0043 | - |
- |
Severe acute respiratory syndrome-related coronavirus | 2-(4-aminophenyl)-6-methyl-1H-benzimidazole-7-sulfonic acid | |
0.007 | - |
- |
Severe acute respiratory syndrome-related coronavirus | 3,4-dichloro-5-[2-(5-chloro-3-methyl-1-benzothien-2-yl)-2-oxoethyl]furan-2(5H)-one | |
0.007 | - |
- |
Severe acute respiratory syndrome-related coronavirus | methyl 4-hydroxy-6-(trifluoromethyl)furo[2,3-b]pyridine-2-carboxylate |