Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P17655 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Homo sapiens | - |
General Information | Comment | Organism |
---|---|---|
physiological function | calpain-1 and calpain-2 play opposite functions in both synaptic plasticity/learning and memory and neuroprotection/neurodegeneration. Calpain-1 activation is necessary for certain forms of synaptic plasticity and learning and memory, while calpain-2 activation during a brief consolidation period limits the extent of plasticity/learning. Calpain-1 is neuroprotective, while calpain-2 is neurodegenerative. Calpain-2 activation, through the selective degradation of phosphatase PTEN, is linked to the regulation of mTOR-mediated local protein synthesis | Homo sapiens |