Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.22.53 extracted from

  • Wang, Y.; Lopez, D.; Davey, P.G.; Cameron, D.J.; Nguyen, K.; Tran, J.; Marquez, E.; Liu, Y.; Bi, X.; Baudry, M.
    Calpain-1 and calpain-2 play opposite roles in retinal ganglion cell degeneration induced by retinal ischemia/reperfusion injury (2016), Neurobiol. Dis., 93, 121-128 .
    View publication on PubMed
Search for more literature for 3.4.22.53

Application

Application Comment Organism
medicine a selective calpain-2 inhibitor could prevent acute glaucoma-induced retinal ganglion cell death and blindness Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
benzyloxycarbonyl-Leu-Abu-CONH-CH2-C6H3(3,5-(OMe)2) calpain-2 selective inhibitor. A selective calpain-2 inhibitor could prevent acute glaucoma-induced retinal ganglion cell death and blindness Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
striatal-enriched protein tyrosine phosphatase + H2O Mus musculus calpain-2 activation cleaves striatal-enriched protein tyrosine phosphatase and activates STEP-mediated pro-death pathway in retinal ganglion cells after intraocular pressure elevation ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus O08529 catalytic subunit
-

Source Tissue

Source Tissue Comment Organism Textmining
retinal ganglion cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
striatal-enriched protein tyrosine phosphatase + H2O
-
 Mus musculus ?
-
 ?
striatal-enriched protein tyrosine phosphatase + H2O calpain-2 activation cleaves striatal-enriched protein tyrosine phosphatase and activates STEP-mediated pro-death pathway in retinal ganglion cells after intraocular pressure elevation Mus musculus ?
-
 ?

General Information

General Information Comment Organism
physiological function calpain-1 and calpain-2 play opposite roles in retinal ganglion cell death induced by acute intraocular pressure elevation. Calpain-1 activity supports survival of retinal ganglion cell after intraocular pressure elevation. Calpain-2 activity promotes cell death of retinal ganglion cells after intraocular pressure elevation. Calpain-2 activation cleaves striatal-enriched protein tyrosine phosphatase and activates STEP-mediated pro-death pathway in retinal ganglion cells after intraocular pressure elevation Mus musculus