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Literature summary for 3.4.22.53 extracted from

  • Sheng, J.J.; Chang, H.; Yu, Z.B.
    Nuclear translocation of calpain-2 mediates apoptosis of hypertrophied cardiomyocytes in transverse aortic constriction rat (2015), J. Cell. Physiol., 230, 2743-2754 .
    View publication on PubMed
Search for more literature for 3.4.22.53

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus angiotensin II increases nuclear translocation of intracellular Ca2þ activated calpain-2 in hypertrophied cardiomyocytes Rattus norvegicus 5634
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
calmodulin-dependent protein kinase II deltaB + H2O Rattus norvegicus angiotensin II enhances the interaction between activated calpain-2 and Ca2+/calmodulin-dependent protein kinase II deltaB (CaMKIIdB), and promotes the degradation of CaMKIIdB by calpain-2 in the nuclei of hypertrophied cardiomyocytes. The depressed CaMKIIdeltaB downregulates the expression of antiapoptotic Bcl-2 leading to mitochondrial depolarization and release of cytochrome c which leads to apoptosis of hypertrophied cardiomyocytes ?
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Organism

Organism UniProt Comment Textmining
Rattus norvegicus Q07009
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Source Tissue

Source Tissue Comment Organism Textmining
cardiomyocyte
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 Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
calmodulin-dependent protein kinase II deltaB + H2O
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 Rattus norvegicus ?
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 ?
calmodulin-dependent protein kinase II deltaB + H2O angiotensin II enhances the interaction between activated calpain-2 and Ca2+/calmodulin-dependent protein kinase II deltaB (CaMKIIdB), and promotes the degradation of CaMKIIdB by calpain-2 in the nuclei of hypertrophied cardiomyocytes. The depressed CaMKIIdeltaB downregulates the expression of antiapoptotic Bcl-2 leading to mitochondrial depolarization and release of cytochrome c which leads to apoptosis of hypertrophied cardiomyocytes Rattus norvegicus ?
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 ?

General Information

General Information Comment Organism
metabolism nuclear translocation of calpain-2 mediates apoptosis of hypertrophied cardiomyocytes in transverse aortic constriction rat. Angiotensin II enhances the interaction between activated calpain-2 and Ca2+/calmodulin-dependent protein kinase II deltaB (CaMKIIdB), and promotes the degradation of CaMKIIdB by calpain-2 in the nuclei of hypertrophied cardiomyocytes. The depressed CaMKIIdeltaB downregulates the expression of antiapoptotic Bcl-2 leading to mitochondrial depolarization and release of cytochrome c which leads to apoptosis of hypertrophied cardiomyocytes Rattus norvegicus