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Literature summary for 3.4.22.53 extracted from

  • Ho, W.C.; Pikor, L.; Gao, Y.; Elliott, B.E.; Greer, P.A.
    Calpain 2 regulates Akt-FoxO-p27(Kip1) protein signaling pathway in mammary carcinoma (2012), J. Biol. Chem., 287, 15458-15465.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.53

Application

Application Comment Organism
medicine calpain 2 represents a potential therapeutic target in breast cancer Mus musculus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
80000
-
 x * 80000, SDS-PAGE Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
AC2M2 cell
-
 Mus musculus
-
breast cancer cell
-
 Mus musculus
-
mammary carcinoma cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
casein + H2O
-
 Mus musculus ?
-
 ?

Subunits

Subunits Comment Organism
? x * 80000, SDS-PAGE Mus musculus

Synonyms

Synonyms Comment Organism
calpain 2
-
 Mus musculus
CAPN2
-
 Mus musculus
m-calpain
-
 Mus musculus

General Information

General Information Comment Organism
malfunction calpain 2 knockdown in breast cancer cells correlates with reduced in vitro proliferation, migration, and in vivo tumorigenicity as well as reduced Akt activation, increased nuclear FoxO localization, and increased p27Kip1 expression Mus musculus
physiological function calpain 2 promotes proliferation of cancer cells through Akt-FoxO-p27Kip1 signaling Mus musculus