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Literature summary for 3.4.22.53 extracted from

  • Jang, H.S.; Lal, S.; Greenwood, J.A.
    Calpain 2 is required for glioblastoma cell invasion: regulation of matrix metalloproteinase 2 (2010), Neurochem. Res., 35, 1796-1804.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.53

Inhibitors

Inhibitors Comment Organism Structure
ALLM
-
 Homo sapiens
ALLN
-
 Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ required for activity Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
glioblastoma cell
-
 Homo sapiens
-
U-87MG cell
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
calpain 2
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction knockdown of calpain 2 expression or chemical inhibition of calpain activity reduces glioblastoma cell invasion by 90%. Decreased expression of calpain 2 does not influence morphology or migration Homo sapiens
physiological function calpain 2 is required for matrix metalloproteinase-2 activity in glioblastoma cells. Calpain 2 is required for glioblastoma cell invasion, but not migration Homo sapiens