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Literature summary for 3.4.22.53 extracted from

  • Chen, H.; Libertini, S.J.; Wang, Y.; Kung, H.J.; Ghosh, P.; Mudryj, M.
    ERK regulates calpain 2-induced androgen receptor proteolysis in CWR22 relapsed prostate tumor cell lines (2010), J. Biol. Chem., 285, 2368-2374.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
calpastatin endogenous inhibitor Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ calpain 2 is activated with addition of CaCl+ to 1 mM Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
androgen receptor + H2O Homo sapiens
-
?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
CWR22-Rv1 cell
-
Homo sapiens
-
DU-145 cell
-
Homo sapiens
-
LNCaP cell
-
Homo sapiens
-
PC-3 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
androgen receptor + H2O
-
Homo sapiens ?
-
?
androgen receptor + H2O
-
Homo sapiens low molecular weight androgen receptor + ?
-
?

Synonyms

Synonyms Comment Organism
calpain 2
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens a 6-day treatment with siRNA results in an about 60% reduction of calpain 2 protein levels in R1 cells down

General Information

General Information Comment Organism
physiological function calpain 2 plays a role in the generation of the low molecular weight-androgen receptor in CWR22-R1 cells Homo sapiens