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Literature summary for 3.4.22.53 extracted from
- Calcium-dependent cleavage of the Na+/Ca2+ exchanger by m-calpain in isolated endoplasmic reticulum (2010), J. Biochem., 147, 225-235.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| calpastatin | - |
Bos taurus | |
| calpeptin | - |
Bos taurus |  |
| EGTA | - |
Bos taurus | |
| MDL28170 | - |
Bos taurus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| endoplasmic reticulum | - |
Bos taurus | 5783 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | treatment of the endoplasmic reticulum with Ca2+ (5 mM) dissociates m-calpain-calpastatin association leading to the activation of m-calpain | Bos taurus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| ammonium sulfate precipitation, DEAE-cellulose column chromatography, phenyl-Sepharose column chromatography, Reactive Red column chromatography, and DEAE-TSK anion exchange column chromatography | Bos taurus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| pulmonary artery smooth muscle cell | - |
Bos taurus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Na+/Ca2+ exchanger + H2O | - |
Bos taurus | 82000 Da fragment + ? | - |
? | |
| SLLVY-7-amido-4-methylcoumarin + H2O | - |
Bos taurus | SLLVY + 7-amino-4-methylcoumarin | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| calpain 2 | - |
Bos taurus |
| m-calpain | - |
Bos taurus |
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Release 2023.1 (January 2023)
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