Inhibitors | Comment | Organism | Structure |
---|---|---|---|
EGTA | - |
Rattus norvegicus | |
PD150606 | - |
Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Rattus norvegicus | 5829 | - |
mitochondrion | - |
Rattus norvegicus | 5739 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | the Ca2+ dependency of mitochondrial m-calpain is similar to that of cytosolic m-calpain, 1 mM Ca2+ activates. | Rattus norvegicus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
79920 | - |
m-calpain large subunit, calculated from amino acid sequence | Rattus norvegicus |
80000 | - |
1 * 80000 + 1 * ?, SDS-PAGE | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
DEAE-Sepharose column chromatography | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
erythrocyte | - |
Rattus norvegicus | - |
liver | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
casein + H2O | - |
Rattus norvegicus | ? | - |
? | |
voltage-dependent anion channel + H2O | mitochondrial m-calpain truncates voltage-dependent anion channel in Ca2+-dependent manner | Rattus norvegicus | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
heterodimer | 1 * 80000 + 1 * ?, SDS-PAGE | Rattus norvegicus |
Synonyms | Comment | Organism |
---|---|---|
calpain 2 | - |
Rattus norvegicus |
mitochondrial m-calpain | m-calpain large subunit | Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
physiological function | mitochondrial m-calpain plays a role in the release of truncated apoptosis-inducing factor from the mitochondria by cleaving voltage-dependent anion channel | Rattus norvegicus |