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Literature summary for 3.4.22.53 extracted from
- Mitochondrial calpain system: an overview (2010), Arch. Biochem. Biophys., 495, 1-7.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| calpastatin | endogenous inhibitor | Rattus norvegicus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Rattus norvegicus | 5829 | - |
| mitochondrion | m-calpain is present in the intermembrane space of the mitochondria | Rattus norvegicus | 5739 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | dependent on | Rattus norvegicus |  |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 30000 | - |
1 * 80000 + 1 * 30000 | Rattus norvegicus |
| 80000 | - |
1 * 80000 + 1 * 30000 | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Rattus norvegicus | ERp75 plays important role in the refolding of mitochondrial m-calpain large subunit, cytosolic m-calpain does not associate with ERp57 | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | ERp75 plays important role in the refolding of mitochondrial m-calpain large subunit, cytosolic m-calpain does not associate with ERp57 | Rattus norvegicus | ? | - |
? | |
| voltage dependent anion channel + H2O | - |
Rattus norvegicus | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| heterodimer | 1 * 80000 + 1 * 30000 | Rattus norvegicus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| calpain 2 | - |
Rattus norvegicus |
| m-calpain | - |
Rattus norvegicus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | mitochondrial m-calpain is associated with ERp75 and plays an important role in releasing of truncated apoptosis-inducing factor from mitochondria | Rattus norvegicus |
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Release 2023.1 (January 2023)
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